BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0064.0004.p         (183 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

MK0395 Non COG                                                         92   5e-19
MTH1206 [R] COG4032 Predicted thiamine-pyrophosphate-binding pro...    83   4e-16
MJ0255a [R] COG4032 Predicted thiamine-pyrophosphate-binding pro...    80   2e-15

>MK0395 Non COG
          Length = 167

 Score = 92.4 bits (228), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 55/156 (35%), Positives = 85/156 (54%), Gaps = 1/156 (0%)

Query: 20  VLQTLKRNEIKLVPYVPDRVLTTLIKDLHADPYFTTFPTAREEEAVGIVSGAWMAGTRGA 79
           +++ L+   I    ++P  +L  +I+ L   P   T   +REEE VGI +GA +AG + A
Sbjct: 7   IVEALEEAGITFACWLPCSLLDGIIRRLEEHPEIRTVRVSREEEGVGICAGAALAGEKPA 66

Query: 80  VLMQTSGFATLANVLASLAVPYQIPLIMFVSERGTLGEFNYGQALVCRTMRPVLDSLAME 139
           ++MQ SG     N L SL + Y++PL+M +S RG L E    Q  + +    +L++L + 
Sbjct: 67  LIMQNSGLGNSVNALCSLTLTYRLPLLMLMSHRGYLFEDIPAQVGMGKAAPKILENLNLH 126

Query: 140 HHTITRLDELEFIADRSIKQAVTTQAPVALILSPLL 175
             TI R +EL+ I   + K A T   PV + LSP L
Sbjct: 127 AFTIERPEELDVIPG-AWKLAETAGEPVGVFLSPRL 161


>MTH1206 [R] COG4032 Predicted thiamine-pyrophosphate-binding protein Mth
           Methanothermobacter thermautotrophicus
          Length = 165

 Score = 82.8 bits (203), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 50/123 (40%), Positives = 62/123 (50%)

Query: 20  VLQTLKRNEIKLVPYVPDRVLTTLIKDLHADPYFTTFPTAREEEAVGIVSGAWMAGTRGA 79
           V   +K   I     VP   L T+++ + ADP     P  REEE  G+ +GA MAG   A
Sbjct: 9   VYAGMKDAGIDFAVSVPCVNLRTVLEMVDADPAIMHVPVTREEEGFGVAAGAHMAGKTTA 68

Query: 80  VLMQTSGFATLANVLASLAVPYQIPLIMFVSERGTLGEFNYGQALVCRTMRPVLDSLAME 139
           +LMQ SG     NVLASL   Y IP+ M VS RGT GEF   Q  + R    +L  L + 
Sbjct: 69  ILMQNSGLGNSVNVLASLYSLYHIPITMIVSHRGTEGEFMEAQVPMGRATGDILRILEIP 128

Query: 140 HHT 142
             T
Sbjct: 129 FRT 131


>MJ0255a [R] COG4032 Predicted thiamine-pyrophosphate-binding protein Mja
           Methanococcus jannaschii
          Length = 183

 Score = 80.5 bits (197), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 49/155 (31%), Positives = 73/155 (47%)

Query: 20  VLQTLKRNEIKLVPYVPDRVLTTLIKDLHADPYFTTFPTAREEEAVGIVSGAWMAGTRGA 79
           +   LK + I  +  VP   L  L+K +  D      P  REEEA GI +GA++AG + A
Sbjct: 21  IYNALKDSNIDFICSVPCANLKNLLKLIEEDKNIINIPATREEEAFGICAGAYLAGKKTA 80

Query: 80  VLMQTSGFATLANVLASLAVPYQIPLIMFVSERGTLGEFNYGQALVCRTMRPVLDSLAME 139
           +LMQ SG     N +ASL   +QIP ++ +S RG L E    Q  + R +  +LD   + 
Sbjct: 81  ILMQNSGIGNSINAIASLYKTFQIPTLLIISHRGDLKEQIPAQIPMGRWIEKLLDVCEIP 140

Query: 140 HHTITRLDELEFIADRSIKQAVTTQAPVALILSPL 174
            +     +E   +   +         PVAL+   L
Sbjct: 141 TYKPKTPEEAYKLIKYASSYMYKISYPVALLFDAL 175