BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0061.0025.p (433 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PM0835 [GEPR] COG0477 Permeases of the major facilitator superfa... 150 7e-36 YPO1932 [GEPR] COG0477 Permeases of the major facilitator superf... 149 1e-35 RSp0797 [GEPR] COG0477 Permeases of the major facilitator superf... 142 1e-33 PA2114 [GEPR] COG0477 Permeases of the major facilitator superfa... 142 1e-33 HI1104 [GEPR] COG0477 Permeases of the major facilitator superfa... 132 2e-30 >PM0835 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 405 Score = 150 bits (378), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 117/409 (28%), Positives = 202/409 (49%), Gaps = 35/409 (8%) Query: 35 GWMLDGFDSSMYAYILVGALSELLPASGIEPSKANIGIYGGLLFSIFMLGWACSMIWGWA 94 G+ +DGFD + ++L ++L + P+++ G L+ + A +I+G Sbjct: 19 GYAMDGFDLLILGFMLSAISADL----ALTPAQS-----GSLVTWTLIGAVAGGIIFGAL 69 Query: 95 ADRYGRVRIMCWTVLVYSLFTALCGLATGIVMFALFRFVAGFRIRGKWAAGTPLLQESVP 154 +D+YGRVR++ WT++++++FT LC A G ++R +AG + G++ G L E+ P Sbjct: 70 SDKYGRVRVLTWTIVLFAVFTGLCAFAQGYWDLLIYRTIAGIGLGGEFGIGMALAAEAWP 129 Query: 155 ENTRVRLAGWLHTATPTGLFLTAAMTLAIGSTLGWRGMFLLGILPALLIAYLRSNIPEPE 214 R + + ++ G+ A +T + +GWRGMFL+GI PA + YLR+ + EPE Sbjct: 130 ARHRAKASSYVALGWQVGVLGAALLTPLLLPHIGWRGMFLVGIFPAFVAWYLRAKLHEPE 189 Query: 215 ----RSAAREQPSVA-----ALFAGDQARTTWAAALMMACII--FGLWSSNFWAPTVIST 263 + A E+ + L D+A +A +++ + FG + W P +S Sbjct: 190 IFVKKQTALERQKTSRLEPFRLLIKDKATAKISAGIVVLTSVQNFGYYGIMIWMPNFLSK 249 Query: 264 KLVAAGATPAHAQEMGAVAGLITNVGTLIGCLLVPWLTTWLGSRRRTAVLFFIGGLISVV 323 +L + V +T G + G L L +G R+ + +LF G +IS+ Sbjct: 250 QL-------GFSLTKSGVWTAVTICGMMFGIWLFGQLADRIG-RKPSFLLFQFGAVISIF 301 Query: 324 VCYEVAIEWLDSLTLFMVLLPVLGFFTNGVFGLFTIWLPEMFPSALRGSGSGFAFSMGRV 383 + + T + VLG F NG+ G + + E +P+ R + F++GR Sbjct: 302 TYSQ-----MSDPTYMLFAGAVLGMFVNGMMGGYGALMSEAYPTQARATAQNVLFNLGRA 356 Query: 384 LGAAGPTLIGALAARTGSFPLAISMLSLIYVVGL-PLIALAPETAGKPL 431 +G GP ++GAL + T SF LAI+ L+ IY++ + I L PE GK L Sbjct: 357 VGGFGPIVVGALVS-TYSFQLAIAFLASIYIIDMIATIFLIPELKGKQL 404 >YPO1932 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 409 Score = 149 bits (376), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 127/422 (30%), Positives = 205/422 (48%), Gaps = 37/422 (8%) Query: 24 SPRKVFWATWFGWMLDGFDSSMYAYILVGALSELLPASGIEPSKANIGIYGGLLFSIFML 83 + RK F A + GW LD D ++ +++ + L+ I+ +A + LLFS + Sbjct: 10 TERKTFIAAFGGWALDALDFMVFTFVI----ATLMALWQIDAGQAGMLSTVTLLFSA-IG 64 Query: 84 GWACSMIWGWAADRYGRVRIMCWTVLVYSLFTALCGLATGIVMFALFRFVAGFRIRGKWA 143 GW ++ ADRYGRVRI+ T+L +SL T L G A + R + G G+WA Sbjct: 65 GWGAGIL----ADRYGRVRILQITILWFSLCTVLIGFAQNFEHVFILRALQGLGFGGEWA 120 Query: 144 AGTPLLQESVPENTRVRLAGWLHTATPTG----LFLTAAMTLAIGSTLGWRGMFLLGILP 199 G+ L+ E V R + G + + G L M + WR +F +G+LP Sbjct: 121 VGSVLMGEIVRAEHRGKAVGTVQSGWAIGWGAAALLYTLMFSVLSEEWAWRALFWIGVLP 180 Query: 200 ALLIAYLRSNIPEP--------ERSAAREQPSVAALFAGDQARTTWAAALMMACIIFGLW 251 ALL+ Y+R N+PEP E+ A + S A+F+ +TT A+L+ + G + Sbjct: 181 ALLVLYIRKNVPEPALFLKSRHEQQAKDRRVSSFAIFSPALLKTTVLASLLCTGVQGGYY 240 Query: 252 SSNFWAPTVISTKLVAAGATPAHAQEMGAVAGLITNV-GTLIGCLLVPWLTTWLGSRRRT 310 + W PT + + + +G L+ + G+ +G + +LT LG RR Sbjct: 241 AITTWLPTFLKLE--------RNLSVIGTGGYLMVIIFGSFVGYICGAYLTDKLG-RRAN 291 Query: 311 AVLFFIGGLISVVVCYEVAIEWLDSLTLFMVLLPVLGFFTNGVFGLFTIWLPEMFPSALR 370 ++F L+S + + L + + ++ P LGF +G+F +L E+FPSA+R Sbjct: 292 LIIF---SLLSCITIFAYTQLTLTNTQMLVLGFP-LGFSASGIFSGMGAFLTELFPSAVR 347 Query: 371 GSGSGFAFSMGRVLGAAGPTLIGALAARTGSFPLAISMLS-LIYVVGLPLIALAPETAGK 429 +G GF +S GR +GA P L+G L +++ S AI + + Y + L + L PET K Sbjct: 348 ATGQGFTYSFGRAVGALFPGLVGYL-SQSSSLAFAIGVFAGSAYCIVLVMSLLLPETKNK 406 Query: 430 PL 431 L Sbjct: 407 QL 408 >RSp0797 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 418 Score = 142 bits (359), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 135/447 (30%), Positives = 219/447 (48%), Gaps = 51/447 (11%) Query: 7 ESTVDTLAPSVAAPGAVSPR------KVFWATWFGWMLDGFDSSMYAYIL--VGALSELL 58 ++ V+T P AP A R K + G+ +DGFD + ++L + A L Sbjct: 2 DAHVNTSVPDTGAPVACPARTSGDAWKALAGSAIGYAMDGFDLLILGFMLPAISAALALT 61 Query: 59 PA-SGIEPSKANIG-IYGGLLFSIFMLGWACSMIWGWAADRYGRVRIMCWTVLVYSLFTA 116 P SG + +G + GG+LF G +D YGRVR++ WT++++++FT Sbjct: 62 PGESGALVTWTLVGAVAGGILF-------------GALSDAYGRVRVLTWTIVLFAVFTG 108 Query: 117 LCGLATGIVMFALFRFVAGFRIRGKWAAGTPLLQESVPENTRVRLAGWLHTATPTGLFLT 176 +C A G ++R +AG + G++ G L E+ P + R R++ ++ G+ L Sbjct: 109 MCAFAQGFTDLLIYRTIAGIGLGGEFGIGMALAAEAWPAHKRARVSSYVALGWQCGVLLA 168 Query: 177 AAMTLAIGSTLGWRGMFLLGILPALLIAYLRSNIPEPE-----RSAAREQPSVAALFAGD 231 A +T + +GWRGMFLLG+LPA + ++R+ + EPE A R + S L D Sbjct: 169 ALLTPLLLPFIGWRGMFLLGVLPAAVAWFIRNRLHEPELFVRHAHAPRGKTSAFRLLVSD 228 Query: 232 QA--RTTWAAALMMACIIFGLWSSNFWAPTVISTKLVAAGATPAHAQEMGAVAGLITNVG 289 RT+ ++ A FG + W PT + G T + A+ +T +G Sbjct: 229 ARTLRTSLGIVILCAVQNFGYYGIMIWLPTYL-------GKTLGFSLTKSALWTSVTILG 281 Query: 290 TLIGCLLVPWLTTWLGSRRRTAVLFFIGGLISVVVCYEVAIEWLDSLTLFMVLL---PVL 346 ++G + L +G R+ L F G +++V+ Y LT + LL V+ Sbjct: 282 MMLGIVAFGHLADRIG--RKPTFLIFQAGAVAMVLTYA-------RLTDPLALLWAGAVM 332 Query: 347 GFFTNGVFGLFTIWLPEMFPSALRGSGSGFAFSMGRVLGAAGPTLIGALAARTGSFPLAI 406 G F NG+ G + + E FP+A R + F++GR +G GP ++G+LAA SF AI Sbjct: 333 GMFVNGMIGGYGALISEAFPTAARATAQNVLFNLGRAVGGFGPVVVGSLAAAY-SFRTAI 391 Query: 407 SMLSLIYVVG-LPLIALAPETAGKPLA 432 ++L+ +YV+ L +AL PE G LA Sbjct: 392 ALLAGLYVLDMLATMALVPERKGAELA 418 >PA2114 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 423 Score = 142 bits (358), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 132/427 (30%), Positives = 207/427 (48%), Gaps = 48/427 (11%) Query: 24 SPRKVFWATWFGWMLDGFDSSMYAYILVGALSELLPASGIEPSKANIGIYGGLLFSIFML 83 R+ FW+ G+ LDG D+ M ++++ L+ GI +A I+ L + Sbjct: 24 QERRAFWSCKIGYGLDGMDTQMLSFVI----PTLIALWGIGTGEAGF-IHTMTLLASAAG 78 Query: 84 GWACSMIWGWAADRYGRVRIMCWTVLVYSLFTALCGLATGIVMFALFRFVAGFRIRGKWA 143 GW I G +DR GRV + TVL ++ FT LCGLA + R + GF G+W Sbjct: 79 GW----IAGILSDRIGRVLTLQLTVLWFAFFTFLCGLAQNYEQLLVARTLMGFGFGGEWT 134 Query: 144 AGTPLLQESVPENTRVRLAGWLHTATPTGLFLTAAMTLAIGSTL----GWRGMFLLGILP 199 AG L+ E + R + G + + G LTA + + S L WR +F+LG+LP Sbjct: 135 AGAVLIGEVIKARDRGKAVGLVQSGWAIGWGLTAILYSLMFSLLPPEEAWRALFMLGLLP 194 Query: 200 ALLIAYLRSNIPEPE-------RSAAREQPSVAALFAGDQARTTWAAALMMACIIFGLWS 252 AL + +R + EPE R+ ++ S +FA T A+L+ + G ++ Sbjct: 195 ALFVLVVRRLVKEPEIYREARQRNQGADKVSFYEIFAPGMLSITLRASLLTTGALGGYYA 254 Query: 253 SNFWAPTVISTK--LVAAGATPAHAQEMGAVAGLITNVGTLIGCLLVPWLTTWLGSRRRT 310 W PT + T+ L G + G +A +I +G+ +G ++ +LT +G R++ Sbjct: 255 ITAWLPTFLKTERGLTVLGTS-------GYLAMVI--LGSYVGYVVSAFLTDLIG-RKKN 304 Query: 311 AVLFFIGGLISVVVCYEV-----AIEWLDSLTLFMVLLPVLGFFTNGVFGLFTIWLPEMF 365 VLF +G V++ ++ A+ WL P LGFF +G+F +L E+F Sbjct: 305 FVLFAVGSFTVVLLYTQLPVSNGAMLWLG--------FP-LGFFASGIFSGMGSFLTELF 355 Query: 366 PSALRGSGSGFAFSMGRVLGAAGPTLIGALAARTGSFPLAISMLSLIYVVGLPLIALA-P 424 P+ +RGSG GF ++ GR + A P LIG L + S L I + + + L AL+ P Sbjct: 356 PTRIRGSGQGFCYNAGRAIAALFPMLIGMLGQKL-SLGLGIGAFAAVSYGVVILAALSLP 414 Query: 425 ETAGKPL 431 ET GK L Sbjct: 415 ETRGKQL 421 >HI1104 [GEPR] COG0477 Permeases of the major facilitator superfamily Hin Haemophilus influenzae Length = 407 Score = 132 bits (331), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 118/415 (28%), Positives = 199/415 (47%), Gaps = 45/415 (10%) Query: 35 GWMLDGFDSSMYAYIL--VGALSELLPASGIEPSKANI--GIYGGLLFSIFMLGWACSMI 90 G+ +DGFD + ++L + A L PA G + ++GG+LF Sbjct: 19 GYGMDGFDLLILGFMLSAISADLNLTPAQGGSLVTWTLIGAVFGGILF------------ 66 Query: 91 WGWAADRYGRVRIMCWTVLVYSLFTALCGLATGIVMFALFRFVAGFRIRGKWAAGTPLLQ 150 G +D+YGRVR++ WT+L++++FT LC +A G ++R +AG + G++ G L Sbjct: 67 -GALSDKYGRVRVLTWTILLFAVFTGLCAIAQGYWDLLIYRTIAGIGLGGEFGIGMALAA 125 Query: 151 ESVPENTRVRLAGWLHTATPTGLFLTAAMTLAIGSTLGWRGMFLLGILPALLIAYLRSNI 210 E+ P R + A ++ G+ A +T + +GWRGMFL+GI PA + +LRS++ Sbjct: 126 EAWPARHRAKAASYVALGWQVGVLGAALLTPLLLPHIGWRGMFLVGIFPAFVAWFLRSHL 185 Query: 211 PEPE-----RSAAREQPSVA------ALFAGDQA--RTTWAAALMMACIIFGLWSSNFWA 257 EPE ++A Q S L D+A + + ++ + FG + W Sbjct: 186 HEPEIFTQKQTALSTQSSFTDKLRSFQLLIKDKATSKISLGIVVLTSVQNFGYYGIMIWL 245 Query: 258 PTVISTKLVAAGATPAHAQEMGAVAGLITNVGTLIGCLLVPWLTTWLGSRRRTAVLFFIG 317 P +S +L G + + AV T G + G + L +G R+ + +LF +G Sbjct: 246 PNFLSKQL---GFSLTKSGLWTAV----TVCGMMAGIWIFGQLADRIG-RKPSFLLFQLG 297 Query: 318 GLISVVVCYEVAIEWLDSLTLFMVLLPVLGFFTNGVFGLFTIWLPEMFPSALRGSGSGFA 377 +IS+VV + L + ++ LG F NG+ G + + E +P+ R + Sbjct: 298 AVISIVVYSQ-----LTDPDIMLLAGAFLGMFVNGMLGGYGALMAEAYPTEARATAQNVL 352 Query: 378 FSMGRVLGAAGPTLIGALAARTGSFPLAISMLSLIYVVG-LPLIALAPETAGKPL 431 F++GR + ++ SF AI++L++IYV+ L I L PE GK L Sbjct: 353 FNIGRAV-GGFGPVVVGSVVLAYSFQTAIALLAIIYVIDMLATIFLIPELKGKAL 406