BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0059.0234.p         (508 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

APE2240 [R] COG2159 Predicted metal-dependent hydrolase of the T...    62   3e-09

>APE2240 [R] COG2159 Predicted metal-dependent hydrolase of the TIM-barrel
           fold Ape Aeropyrum pernix
          Length = 324

 Score = 62.4 bits (150), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 64/219 (29%), Positives = 100/219 (45%), Gaps = 39/219 (17%)

Query: 259 WRLDDEKVAYKGYEKMVKAGIRNVCVHKGLFPPGIEKQYPNLRGFADVADVGQAAKDWPQ 318
           WRLD  + A++  E   + GI     HKG   P +   +P  +   DV DV  AA  +P+
Sbjct: 129 WRLDSPQ-AFEFLEFNRELGIDIQVPHKG---PTV---WPLSKDAFDVHDVDTAASSFPE 181

Query: 319 LNFIIYHSAYRHVGGDPKVALAEFERTGRIAWTSDLADIPAQYGVNNVYGDVGQLFATTL 378
           L F++ H       G P++               D + I  Q    NVY   G   AT  
Sbjct: 182 LRFVVTHV------GLPRI--------------DDFSWIGVQ--DKNVYA--GLAVATAF 217

Query: 379 VAE-PNVCAALMGTLIKGLGVDHVCWGTD-ALWTGAPQWQIEGLRRLEIPETMQKKFGYA 436
           + + P   A +M  L+  LG D + +G+D A+W   P+W IE   + E+P  ++ ++G  
Sbjct: 218 IRKRPKYFAEIMAELLFWLGPDRIIFGSDYAIWH--PKWIIEDFIKFELPRDLESEYG-V 274

Query: 437 PLGPADGPVKTAIFGDNNARLYNIQPKRAMLDLKGDRFA 475
            L   +   K  I G+N ARL+ I  + A   ++ D+ A
Sbjct: 275 ELTLEN---KKKILGENAARLWGIDVEEAKKAVREDQIA 310