BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0059.0038.p (447 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SSO2127 [GEPR] COG0477 Permeases of the major facilitator superf... 183 7e-46 AF0367 [GEPR] COG0477 Permeases of the major facilitator superfa... 162 2e-39 Ta0197 [GEPR] COG0477 Permeases of the major facilitator superfa... 137 5e-32 TVN1396 [GEPR] COG0477 Permeases of the major facilitator superf... 128 3e-29 SPy1392 [GEPR] COG0477 Permeases of the major facilitator superf... 127 4e-29 >SSO2127 [GEPR] COG0477 Permeases of the major facilitator superfamily Sso Sulfolobus solfataricus Length = 430 Score = 183 bits (465), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 140/435 (32%), Positives = 230/435 (52%), Gaps = 29/435 (6%) Query: 11 GGFRWLQLAIGIVCMAMIANLQYGWTLFVDPIDAKFHW--GRPAIQLAFTIFVMTETWLV 68 G FRW+ + + MA+++ +Y WTL+ P+ FH G PA+ L +TI+++ + + Sbjct: 10 GWFRWMLVVGATISMALVSVYEYSWTLYTVPLGRVFHVAPGSPALGLTYTIYIIVQALSM 69 Query: 69 PVEAWFVDKYGPRIVIMFGGLMIGLAWVMNSYASSLVTLYAAAIVAGIGAGAVYGTCVGN 128 V D+YGPR++ M GG++ G+ ++ +++A SL LY IG G +YGT + Sbjct: 70 FVAGRIADRYGPRLISMLGGIITGIGYISSAFAKSLPILYLTYGFGSIGVGIIYGTAIST 129 Query: 129 ALKWFPDRRGLAAGATAAGFGAGAALTVVPIANMIAASGYQSTFLTFGIGQGLIVILLAW 188 A+KWFPD+RGLA G GFG G+ I +I + Y + F GI Q +++ LLA+ Sbjct: 130 AVKWFPDKRGLATGIIEIGFGGGSFALSPLIQYIITSISYTAAFTYMGIVQLIVITLLAF 189 Query: 189 FVR--PPH------GVEAPRKKRLNLPQSAIDYTPPQVLRTPIFWVMYLVFVMVASGGLM 240 F PP E KKR + +S DYT Q+++T +WV+Y+ F ++A GL Sbjct: 190 FFAYPPPQWLPKGFNAEEYEKKRKMIKRSKNDYTVSQMVKTWQWWVIYIAFFLIAGSGLS 249 Query: 241 TAAQIGPIAHDFKIADTPVTLAGFQMAALTFAISLDRVFDGFGRPLFGWVSDNIGREHTM 300 + P GF +AA+ A+ L +G GR + G VSD +GR +TM Sbjct: 250 IIGHLIPYGRSL----------GFSIAAV-IAVFLFPFANGLGRFVMGTVSDYLGRPYTM 298 Query: 301 FIAFATAALMLLTLSTYGHVPVVFVLATAIYF---GVFGEIYSLFPATSGDTFGAKYATT 357 ++F + + +L+++ +P + L A+ F +G ++SLFP GD +G K++ Sbjct: 299 TLSFGISGISMLSIA---FIPKIASLYLALIFLTAFTWGPLFSLFPPLVGDYYGPKHSGA 355 Query: 358 NNGMLYTAKGTAALLVPL-ASIISSQLGWQAVFIVAVALNATAALTALLLIKP-MRRAFI 415 N G+ YTAK A + ASI+ + G + I+ ++ +A+ AL L P + A I Sbjct: 356 NYGLTYTAKALAGIFAGYGASILFTSYGIKETLIITGSMAIMSAILALTLRPPKIPTAQI 415 Query: 416 LGSEATASAAIARAK 430 G+E+ + ++ K Sbjct: 416 AGAESQKGSIESKTK 430 >AF0367 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu Archaeoglobus fulgidus Length = 397 Score = 162 bits (409), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 122/413 (29%), Positives = 205/413 (49%), Gaps = 38/413 (9%) Query: 14 RWLQLAIGIVCMAMIANLQYGWTLFVDPIDAKFHWGRPAIQLAFTIFVMTETWLVPVEAW 73 +WL + G + M+ + Y W++FV+P+ F W + L F+IF++ ++ Sbjct: 4 KWLVIFAGFLLNLML-GIVYAWSVFVNPLMNTFGWSKTIASLPFSIFLLIFALMMVPAGR 62 Query: 74 FVDKYGPRIVIMFGGLMIGLAWVMNSYASSLVT----LYAAAIVAGIGAGAVYGTCVGNA 129 D+ GPR V M GG+++G+ ++++ S+ + +++ ++AG G G Y + A Sbjct: 63 TQDRIGPRKVAMLGGVLLGVGFLLSGLIESIQSPYWLIFSYGVIAGAGCGLGYACPIPVA 122 Query: 130 LKWFPDRRGLAAGATAAGFGAGAALTVVPIAN-MIAASGYQSTFLTFGIGQGLIVILLAW 188 KWFP+R GLA G GFG +AL P+ +I G +TF G+ I++++A Sbjct: 123 RKWFPERVGLATGLVVMGFGM-SALIFAPLERILIDTYGISTTFYILGV----ILLIVAV 177 Query: 189 FV-----RPPH--GVEAPRKKRLNLPQSAIDYTPPQVLRTPIFWVMYLVFVMVASGGLMT 241 F PP V+A ++ + + P ++LR F+V++L F +A GLM Sbjct: 178 FAASLLSNPPELPAVQASNPAKVEVVTGKPELGPSEMLRDYRFYVLWLSFFFMALAGLMV 237 Query: 242 AAQIGPIAHDFKIADTPVTLAGFQMAALTFAISLDRVFDGFGRPLFGWVSDNIGREHTMF 301 I P A + G + A FA+S+ V + GRP G +SD IGR TMF Sbjct: 238 IGHIAPYAQE----------RGLEPLAAAFAVSILSVANAVGRPGAGALSDKIGRAMTMF 287 Query: 302 IAFATAALMLLTLSTYGHVPV----VFVLATAIYFGVFGEIYSLFPATSGDTFGAKYATT 357 + F + TL + HV + +++ A I F +G +SLFP+ +GD FG K Sbjct: 288 VLFLIQGI---TLIAFPHVALTLITIYICAAIIGFN-YGANFSLFPSATGDFFGTKNLGV 343 Query: 358 NNGMLYTAKGTAALLVPLAS--IISSQLGWQAVFIVAVALNATAALTALLLIK 408 N G+++T+ G L+ P+ + + ++ F+VA L AA + LL + Sbjct: 344 NYGLVFTSYGVGGLVGPIMAGYVFDVTGSYEIAFLVAGVLALIAAFMSFLLRR 396 >Ta0197 [GEPR] COG0477 Permeases of the major facilitator superfamily Tac Thermoplasma acidophilum Length = 371 Score = 137 bits (345), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 99/361 (27%), Positives = 170/361 (47%), Gaps = 45/361 (12%) Query: 18 LAIGIVCMAMIANLQYGWTLFVDPIDAKFHWGRPAIQLAFTIFVMTETWLVPVEAWFVDK 77 L I +V M+M + QY W + I H +++AFT+F + T V +F D+ Sbjct: 6 LVIALVVMSMNSLYQYSWNVLEPMISIDLHTSTVYVEVAFTLFTVFSTTFQGVGGYFADR 65 Query: 78 YGPRIVIMFGGLMIGLAWVMNSYASSLVTLYAAAIVAGIGAGAVYGTCVGNALKWFPDRR 137 GP + M ++ ++ S+ S+ YA + IG G +YG A+KW+ + R Sbjct: 66 DGPARIGMISAILSAFGFLGGSFVHSIYEFYAVWSIGSIGEGILYGIATNLAVKWYSNIR 125 Query: 138 GLAAGATAAGFGAGAALTVVPIAN--MIAASGYQSTFLTFGIGQGLIVILLAWFVRPPHG 195 G A G + GFG G++ +AN ++ A+G+++ L G+ + +++ +L + R P Sbjct: 126 GFAVGIVSLGFGLGSS-----VANVFLVHATGFRAPMLIIGLMEIVLMPILMYLTRYPGT 180 Query: 196 VEAPRKKRLNLPQSAIDYTPPQVLRTPIFWVMYLVFVMVASGGLMTAAQIGPIAHDFKIA 255 + R NL +P+FW++Y FV + L+ ++ G I Sbjct: 181 SLTGERPRRNLS-------------SPVFWILYASFVFGSVPLLVISSSFGYI------- 220 Query: 256 DTPVTLAGFQMAALTFA--ISLDRVFDGFGRPLFGWVSDNIGREHT--MFIAFATAALML 311 G + AL F+ +S+ + G RP+ GW+SD IGR + M F A Sbjct: 221 -------GRHLPALEFSLLVSIFPLMSGISRPMIGWLSDRIGRSASVMMIDVFIIAGSAF 273 Query: 312 LTLSTYGHVPVVFVLATAIYFGVFGEIYSLFPATSGDTFGAKYATTNNGMLYTAKGTAAL 371 L Y +P + ++ +FG G + SL+ + GD FG +++T NNG+ YT K + Sbjct: 274 LVARQY--IPAIVIIG---FFG--GSMISLYFSYIGDVFGTRFSTANNGVFYTGKSISGF 326 Query: 372 L 372 + Sbjct: 327 I 327 >TVN1396 [GEPR] COG0477 Permeases of the major facilitator superfamily Tvo Thermoplasma volcanium Length = 375 Score = 128 bits (321), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 104/364 (28%), Positives = 174/364 (47%), Gaps = 51/364 (14%) Query: 18 LAIGIVCMAMIANLQYGWTLFVDPIDAK-FHWGRPAIQLAFTIFVMTETWLVPVEAWFVD 76 L I ++ M + QY W +F +P+ AK F ++Q+AFT+F + T + +F D Sbjct: 6 LIIALLVMCFNSLYQYSWNVF-EPLLAKGFGVEIVSVQIAFTLFAVFSTTFQGIGGYFAD 64 Query: 77 KYGPRIVIMFGGLMIGLAWVMNSYASSLVTLYAAAIVAGIGAGAVYGTCVGNALKWFPDR 136 + GPR V + LM +V +S S+ Y + IG G +YG A+KW+ R Sbjct: 65 RDGPRNVSIAAALMSAFGFVASSLVHSIYLFYVIWSIGSIGEGILYGIATNLAVKWYSGR 124 Query: 137 RGLAAGATAAGFGAGAALTVVPIANMI--AASGYQSTFLTFGIGQGLIVILLAWFVR-PP 193 RG A G + GFG G++ IAN+ AS ++ + G+ + +++ LL FV+ P Sbjct: 125 RGFAVGFVSLGFGLGSS-----IANIFLEKASEFRFPMMFIGLAELIVLPLLLSFVKYPS 179 Query: 194 HGVEAPRKKRLNLPQSAIDYTPPQVLRTPIFWVMYLVFVMVASGGLMTAAQIGPIAHDFK 253 G+ R P + ++ P FW++YL FV + ++ ++ G I Sbjct: 180 SGLTGER--------------PSRNIKNPRFWILYLSFVFGSIPLIVISSSFGFI----- 220 Query: 254 IADTPVTLAGFQMAALTFA--ISLDRVFDGFGRPLFGWVSDNIGREHTMF---IAFATAA 308 G ++ L FA +S+ + G RP+ G +SD IGR ++ +A A Sbjct: 221 ---------GSKLPELEFAVLVSIFPLLSGISRPIIGAISDAIGRPASVLLIDVAIFIGA 271 Query: 309 LMLLTLSTYGHVPVVFVLATAIYFGVFGEIYSLFPATSGDTFGAKYATTNNGMLYTAKGT 368 L L+ + +F + +FG G + SL+ + GD FG +++T NNG+ YT K Sbjct: 272 LFLVLRN------FIFAVVLIGFFG--GSMISLYFSLIGDVFGTRFSTANNGIFYTGKAV 323 Query: 369 AALL 372 + + Sbjct: 324 SGFM 327 >SPy1392 [GEPR] COG0477 Permeases of the major facilitator superfamily Spy Streptococcus pyogenes M1 GAS Length = 398 Score = 127 bits (320), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 113/407 (27%), Positives = 196/407 (48%), Gaps = 37/407 (9%) Query: 14 RWLQLAIGIVCMAMIANLQYGWTLFVDPIDAKFHWGRPAIQLAFTIFVMTETWLVPVEAW 73 R++ GI+ M+ + Y W+++ +PI + W + + AF++ + Sbjct: 6 RYIIATAGILLHLMLGS-TYAWSVYRNPILQETGWDQAPVAFAFSLAIFCLGLSAAFMGN 64 Query: 74 FVDKYGPRIV-----IMF--GGLMIGLAWVMNSYASSLVTLYAA-AIVAGIGAGAVYGTC 125 V++YGPR+ I++ G ++ GLA + LY ++ G+G GA Y T Sbjct: 65 LVEQYGPRLTGTVSAILYASGNMLTGLA----IDRKEIWLLYIGYGVIGGLGLGAGYITP 120 Query: 126 VGNALKWFPDRRGLAAGATAAGFGAGAALTVVPIAN-MIAASGYQSTFLTFGIGQGLIVI 184 + +KWFPD+RG+A G GFG + LT PIA +I G +TF G+ ++++ Sbjct: 121 ISTIIKWFPDKRGMATGFAIMGFGFASLLT-SPIAQWLIETEGLVATFYLLGLIYLIVML 179 Query: 185 LLAWFVRPPHGVEAP--RKKRLNLPQSAID-YTPPQVLRTPIFWVMYLVFVMVASGGLMT 241 + + P E KKRL I+ T + L+T F+ ++++ + + GL Sbjct: 180 FASQLIIKPTAAEIAILDKKRLQNNSYLIEGMTAKEALKTKSFYCLWVILFINITCGLGL 239 Query: 242 AAQIGPIAHDFKIADTPVTLAGFQMAALTFAISLDRVFDGFGRPLFGWVSDNIGREHTMF 301 + + P+A D +P +M+A+ + +F+GFGR ++ +SD IGR T+ Sbjct: 240 ISVVAPMAQDLT-GMSP------EMSAI--VVGAMGIFNGFGRLVWASLSDYIGRRVTVI 290 Query: 302 IAFATAALMLLTLSTYGHVPVVFVLATAIYFGVFGEIYSLFPATSGDTFGAKYATTNNGM 361 + F + +M ++L + H ++F+++ A +G +SL P D FGAK T +G Sbjct: 291 LLFLVSIIMTISL-IFAHSSLIFMISIATLMTCYGAGFSLIPPYLSDLFGAKELATLHGY 349 Query: 362 LYTAKGTAALLVPLASIISSQLGWQ-------AVFIVAVALNATAAL 401 + TA AAL P+ ++S + W VFIV L AL Sbjct: 350 ILTAWAIAALTGPM--LLSITVEWTHNYLLTLCVFIVLYILGLMVAL 394