BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0050.0052.p (481 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0366 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pse... 400 e-111 CC1849 [C] COG1012 NAD-dependent aldehyde dehydrogenases Ccr Cau... 365 e-100 mlr4051 [C] COG1012 NAD-dependent aldehyde dehydrogenases Mlo Me... 363 e-100 VCA1067 [C] COG1012 NAD-dependent aldehyde dehydrogenases Vch Vi... 357 3e-98 alr3672 [C] COG1012 NAD-dependent aldehyde dehydrogenases Nos No... 300 4e-81 >PA0366 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pseudomonas aeruginosa Length = 476 Score = 400 bits (1027), Expect = e-111, Method: Compositional matrix adjust. Identities = 219/454 (48%), Positives = 282/454 (62%), Gaps = 9/454 (1%) Query: 14 TEFQSCFDKQRAAYLAAPEPSYAQRKADLKALAQLLKDNKDELVAAINADYGNRSEFETL 73 + ++ F +QRAAYLA P P QR LKAL LL + L+ AI+ D+ RS ETL Sbjct: 16 NQLEALFARQRAAYLAQPMPDATQRVQWLKALRDLLFKEQQALIEAIDRDFSARSADETL 75 Query: 74 FAEYFVVLETIADAAKNLKKWMKPQRRHVDFMTYPLARNRVIPQPLGVVGVIVPWNFPLN 133 AE L I AAK +KKWMKP RR V P A +V+ QPLGVVGVIVPWN+PL Sbjct: 76 LAEIMPSLHGIHYAAKRVKKWMKPARRAVGLQFQP-ASAQVVYQPLGVVGVIVPWNYPLF 134 Query: 134 LSFCPLAAILAAGNRAMVKMSENSKALAQVLMRVSPKYFPIEKLAFFEDGGGRGPGFSSL 193 LS PL LAAGNR M+KMSE++ A ++L + + FP +++A G FS L Sbjct: 135 LSIGPLTGALAAGNRVMIKMSESTPATGRLLKDLLARIFPEDQVAVVLGEVDVGVAFSKL 194 Query: 194 PFDHLLFTGSGATGRSVMANAARNLTPVTLELGGKAPAIVGPDFPVKTAAERILWAKMFN 253 PFDHLLFTG+ + G+ VM AA NLTPVTLELGGK+PAIV P+K AAERI + K N Sbjct: 195 PFDHLLFTGATSVGKHVMRAAAENLTPVTLELGGKSPAIVSDSVPMKDAAERIAFGKSLN 254 Query: 254 AGQICTNVDYMFLPKGSEDEFVRHCRRLFADRFPDINGQ-DYTSIIDERSFARLQATLED 312 AGQ C DY+ +P +EFV + + FP ++ DYT+II+ER RL+ L+D Sbjct: 255 AGQTCVAPDYVLVPSRRVEEFVSQYKEVVQGFFPRLSDNPDYTAIINERQLGRLRGYLDD 314 Query: 313 ARTKGAVLINL-AEQQEPDAKRRKFAPYLVLNPTEDMIVMQREIFGPILPIKTYADRREV 371 AR KGA L+ L AE Q+ R+ L+LN ++DM VMQ EIFGP+LP+ Y + Sbjct: 315 AREKGATLVPLFAEGQQ-----RRLPQTLLLNVSDDMKVMQEEIFGPLLPVIPYERLEDA 369 Query: 372 AEYINSHDRPLAIYPFTHNAELRDFYISRVMSGGVSVNEALLHVGQHDLPFGGVGASGMG 431 Y+N RPLA+Y F ++ + + SGGV +N+ LLHV Q D+PFGGVG SGMG Sbjct: 370 LAYVNQRPRPLALYYFGYDKAQQQRVLHETHSGGVCLNDTLLHVAQDDIPFGGVGPSGMG 429 Query: 432 HYHAREGFNTFSKLRPVFYQGPLSPIQMLFQPPY 465 HYH EGF TFSK + VF + + +M++ PPY Sbjct: 430 HYHGHEGFLTFSKAKGVFSKPRFNAARMIY-PPY 462 >CC1849 [C] COG1012 NAD-dependent aldehyde dehydrogenases Ccr Caulobacter vibrioides Length = 485 Score = 365 bits (937), Expect = e-100, Method: Compositional matrix adjust. Identities = 202/484 (41%), Positives = 279/484 (57%), Gaps = 6/484 (1%) Query: 1 MNVPVNFRSIAIATEFQSCFDKQRAAYLAAPEPSYAQRKADLKALAQLLKDNKDELVAAI 60 MN PVN S A +Q+AA+L PS +R L LL ++ E+ A+ Sbjct: 1 MNAPVNLSSDAHKAVMNDVLQRQKAAHLRDGPPSAEKRIQWLNRCIDLLVGHQAEIAKAV 60 Query: 61 NADYGNRSEFETLFAEYFVVLETIADAAKNLKKWMKPQRRHVDFMTYPL--ARNRVIPQP 118 N D+G+RS T + + + A ++L KWMKP++ L A+ V QP Sbjct: 61 NQDFGSRSPEATSLTDVAGSIGPLKHAREHLTKWMKPEKHKTTPAILGLFGAKATVQWQP 120 Query: 119 LGVVGVIVPWNFPLNLSFCPLAAILAAGNRAMVKMSENSKALAQVLMRVSPKYFPIEKLA 178 GVVGVI PWNFP+NL+F PLA + AAGNRAM+K SE + A + +L + K F E++A Sbjct: 121 KGVVGVISPWNFPVNLTFAPLAGVFAAGNRAMIKPSEFTPATSDLLKAMFAKAFNEEEVA 180 Query: 179 FFEDGGGRGPGFSSLPFDHLLFTGSGATGRSVMANAARNLTPVTLELGGKAPAIVGPDFP 238 F G G FS L FDHL+FTG+ + + VM AA NL PVTLELGGK+P I+ Sbjct: 181 VFVGGPEVGQAFSGLAFDHLVFTGATSVAKHVMRAAAENLVPVTLELGGKSPVILSRGAD 240 Query: 239 VKTAAERILWAKMFNAGQICTNVDYMFLPKGSEDEFVRHCRRLFADRFPDI-NGQDYTSI 297 + TAA R++ K NAGQIC DY+ P+ + FV+ + + FP I + DYT++ Sbjct: 241 MATAAARVMNGKTLNAGQICLAPDYVLAPQEDVEAFVKEAQAAVSRYFPTIKDNPDYTAV 300 Query: 298 IDERSFARLQATLEDARTKGA--VLINLAEQQEPDAKRRKFAPYLVLNPTEDMIVMQREI 355 + +R + R++ ++DAR KGA + IN A + + RK P L+L+PT+DM VMQ EI Sbjct: 301 VAQRHYDRVKGYVDDARAKGARVIEINPAGEDLSQQEHRKIPPTLILDPTDDMKVMQEEI 360 Query: 356 FGPILPIKTYADRREVAEYINSHDRPLAIYPFTHNAELRDFYISRVMSGGVSVNEALLHV 415 FGP+LP+K Y E +Y+N+HDRPLA+Y F + +D + R SGGV+VN+ + HV Sbjct: 361 FGPVLPVKGYKTVDEAVDYVNAHDRPLALYWFGTDEAEKDRVLERTTSGGVTVNDVIFHV 420 Query: 416 GQHDLPFGGVGASGMGHYHAREGFNTFSKLRPVFYQGPLSPIQML-FQPPYSGRPMSILR 474 Q +LPFGG+G +GMG YH +GF FS + VF Q ML +PPY L Sbjct: 421 AQENLPFGGIGPAGMGAYHGYDGFREFSHRKAVFQQLKKDIAPMLGLRPPYGEGIRKYLA 480 Query: 475 TMIK 478 IK Sbjct: 481 GQIK 484 >mlr4051 [C] COG1012 NAD-dependent aldehyde dehydrogenases Mlo Mesorhizobium loti Length = 473 Score = 363 bits (931), Expect = e-100, Method: Compositional matrix adjust. Identities = 198/448 (44%), Positives = 266/448 (59%), Gaps = 4/448 (0%) Query: 20 FDKQRAAYLAAPEPSYAQRKADLKALAQLLKDNKDELVAAINADYGNRSEFETLFAEYFV 79 F QRAA+ P P + RK LK L L + ++ ++ AAI+AD+G RS ET AE FV Sbjct: 13 FRLQRAAFEKQPFPDPSVRKDRLKRLLALTEHHEADICAAIDADFGGRSAHETRLAELFV 72 Query: 80 VLETIADAAKNLKKWMKPQRRHVDFMTYPLARNRVIPQPLGVVGVIVPWNFPLNLSFCPL 139 V I +L WM+ +RR + + RNR++PQPLGVVG++ PWN+P L+ P+ Sbjct: 73 VRAGIRHTLSHLSGWMR-ERRVATTLPFLPGRNRLLPQPLGVVGIVSPWNYPFQLAVAPV 131 Query: 140 AAILAAGNRAMVKMSENSKALAQVLMRVSPKYFPIEKLAFFEDGGGRGPGFSSLPFDHLL 199 A LAAGNR +VK SE + A + +L R++ ++F ++L+ G F S PFDHLL Sbjct: 132 TAALAAGNRVLVKPSELTPAFSALLARLAGEHFAPDELSVITGDAEMGKAFVSKPFDHLL 191 Query: 200 FTGSGATGRSVMANAARNLTPVTLELGGKAPAIVGPDFPVKTAAERILWAKMFNAGQICT 259 FTGS A GR V AA NLTPVTLELGGK+PAI P + A I + K+ NAGQ C Sbjct: 192 FTGSTAVGRQVAIAAAANLTPVTLELGGKSPAIFDPSCDLDAATASIAYGKLLNAGQTCI 251 Query: 260 NVDYMFLPKGSEDEFVRHCRRLFADRFPDI-NGQDYTSIIDERSFARLQATLEDARTKGA 318 DY+ +PKG A +P + + DYT+II ER F RL+A + +AR GA Sbjct: 252 APDYLLVPKGQAGTVAAKLATAVAQLYPTLRDNPDYTAIISERHFQRLRAMIAEARDAGA 311 Query: 319 VLINLAEQQEP-DAKRRKFAPYLVLNPTEDMIVMQREIFGPILPIKTYADRREVAEYINS 377 ++ + E A RK P LV N D+ +M+ EIFGP+LPI YA E ++N Sbjct: 312 DVVEINPAGEDFGAASRKLLPTLVSNAGPDLRLMREEIFGPVLPIIEYATIDEAISHVNQ 371 Query: 378 HDRPLAIYPFTHNAELRDFYISRVMSGGVSVNEALLHVGQHDLPFGGVGASGMGHYHARE 437 DRPLA+Y F ++ R + ++GGV++N+ +LH+ Q + PFGGVGASGMG YH Sbjct: 372 ADRPLALYWFGKDSTNRQRILRETVAGGVTINDCMLHLVQENQPFGGVGASGMGAYHGEW 431 Query: 438 GFNTFSKLRPVFYQGPLSPIQMLFQPPY 465 GF TFSK +PVF Q LS L +PPY Sbjct: 432 GFRTFSKEKPVFLQSRLS-AGALLRPPY 458 >VCA1067 [C] COG1012 NAD-dependent aldehyde dehydrogenases Vch Vibrio cholerae Length = 480 Score = 357 bits (917), Expect = 3e-98, Method: Compositional matrix adjust. Identities = 196/442 (44%), Positives = 254/442 (57%), Gaps = 6/442 (1%) Query: 16 FQSCFDKQRAAYLAAPEPSYAQRKADLKALAQLLKDNKDELVAAINADYGNRSEFETLFA 75 Q+ F + + Y P PS R L L Q L + L+AA+N DYG RS F++ Sbjct: 22 LQAEFTRLKRQYANTPYPSLTHRLQRLTQLKQALLRENEALIAAVNQDYGFRSRFDSGLC 81 Query: 76 EYFVVLETIADAAKNLKKWMKPQRRHVDFMTYPLARNRVIPQPLGVVGVIVPWNFPLNLS 135 + L + AK LKKWMKPQRRH +M P +R V QPLGVVGV+VPWNFP+ LS Sbjct: 82 DLLPTLNHLNYTAKQLKKWMKPQRRHAGWMLLP-SRVEVQFQPLGVVGVMVPWNFPILLS 140 Query: 136 FCPLAAILAAGNRAMVKMSENSKALAQVLMRVSPKYFPIEKLAFFEDGGGR-GPGFSSLP 194 PL +AAGN+ MVK+SE + A QVL RV + +A G + FS+L Sbjct: 141 IAPLITAVAAGNQVMVKLSEYTPATNQVLARV---IAALGDIAVCVQGDAKVAAAFSALR 197 Query: 195 FDHLLFTGSGATGRSVMANAARNLTPVTLELGGKAPAIVGPDFPVKTAAERILWAKMFNA 254 FDHLLFTGS A G+ V AA+NLTPVTLELGGK+P I+ D + + + I+ K NA Sbjct: 198 FDHLLFTGSTAVGKLVAQAAAKNLTPVTLELGGKSPVIIADDADLARSVDNIMLGKTTNA 257 Query: 255 GQICTNVDYMFLPKGSEDEFVRHCRRLFADRFPDINGQDYTSIIDERSFARLQATLEDAR 314 GQIC DY+ LP+ FV + FA RF D T II++ F RLQ L+DA+ Sbjct: 258 GQICVAPDYVMLPQAKVATFVELYLQRFARRFIRHGRMDVTQIINQAQFDRLQHCLDDAQ 317 Query: 315 TKGAVLINLAEQQEPDAKRRKFAPYLVLNPTEDMIVMQREIFGPILPIKTYADRREVAEY 374 KGA L N + + + R+ P+L+ ++DM+VMQ+EIFGPILP+ Y + E E Sbjct: 318 QKGAKL-NTVVGKTVELEARQMLPHLLTEVSDDMLVMQQEIFGPILPVIGYRNIEEAIER 376 Query: 375 INSHDRPLAIYPFTHNAELRDFYISRVMSGGVSVNEALLHVGQHDLPFGGVGASGMGHYH 434 +N RPLA+Y T + L + + R SGG VN+ L+HV D PFGG+G SG GHYH Sbjct: 377 VNQGPRPLALYVMTKESHLANHILQRTHSGGACVNDTLMHVAADDAPFGGIGESGQGHYH 436 Query: 435 AREGFNTFSKLRPVFYQGPLSP 456 EGF TFS + V P Sbjct: 437 GIEGFKTFSHSKTVLRSAAWLP 458 >alr3672 [C] COG1012 NAD-dependent aldehyde dehydrogenases Nos Nostoc sp. PCC 7120 Length = 460 Score = 300 bits (769), Expect = 4e-81, Method: Compositional matrix adjust. Identities = 175/470 (37%), Positives = 258/470 (54%), Gaps = 19/470 (4%) Query: 13 ATEFQSCFDKQRAAYLAAPEPSYAQRKADLKALAQLLKDNKDELVAAINADYGNRSEFET 72 ++ + +QR + A R LK L +L+ DN+ + A+ AD N+SE+E Sbjct: 6 TSKIKEIIQQQRNFFQAGQTKDINFRLEQLKKLRKLVTDNETAITKALKADL-NKSEYEA 64 Query: 73 LFAEYFVVLETIADAAKNLKKWMKPQRRHV--DFMTYPLARNRVIPQPLGVVGVIVPWNF 130 FAE V+ E I A KNLK W KP++ V DF +Y R+ P+PLGVV +I PWN+ Sbjct: 65 YFAEVGVIKE-IDYAIKNLKNWSKPKKADVPLDFFSY---SARIYPEPLGVVLIICPWNY 120 Query: 131 PLNLSFCPLAAILAAGNRAMVKMSENSKALAQVLMRVSPKYFPIEKLAFFEDGGGRGPGF 190 P L+ PL +AAGN A++K SE + + + ++ K FP E +A E G Sbjct: 121 PFALTISPLVGAIAAGNCAIIKPSELAPHTSNLAAQLISKCFPSEYVAVVEGGAETSQEL 180 Query: 191 SSLPFDHLLFTGSGATGRSVMANAARNLTPVTLELGGKAPAIVGPDFPVKTAAERILWAK 250 + FDH+ FTG A G+ VM AA++LTPVTLELGGK+P IV + ++ A+RI W K Sbjct: 181 LAEKFDHIFFTGGTAIGKIVMEAAAKHLTPVTLELGGKSPCIVDSNIHLEYTAKRIAWGK 240 Query: 251 MFNAGQICTNVDYMFLPKGSEDEFVRHCRRLFADRFPD--INGQDYTSIIDERSFARLQA 308 NAGQ C DY+ + + + + + ++ + + D I+ DY II R F RL Sbjct: 241 FINAGQTCIAPDYLLVNQKIKKDLIAAIQKNLQEFYGDNPIDSPDYGRIISHRHFERLAK 300 Query: 309 TLEDARTKGAVLINLAEQQEPDAKRRKFAPYLVLNPTEDMIVMQREIFGPILPIKTYADR 368 L++ G V++ E + + + AP L+ N + VMQ EIFGPILP+ Y D Sbjct: 301 FLKN----GQVIVG----GETNYEDKYIAPTLLDNVSLADPVMQEEIFGPILPMIEYTDI 352 Query: 369 REVAEYINSHDRPLAIYPFTHNAELRDFYISRVMSGGVSVNEALLHVGQHDLPFGGVGAS 428 ++ INS +PLA+Y F+ N L+ + SGGV +N+ ++HVG LPFGGVG S Sbjct: 353 KDAIALINSQPKPLALYIFSQNKALQQQVLQETSSGGVCINDTIMHVGVSSLPFGGVGDS 412 Query: 429 GMGHYHAREGFNTFSKLRPVFYQGPLSPIQMLFQPPYSGRPMSILRTMIK 478 G+G YH + F+TFS + V + + PY + +S+L+ M+K Sbjct: 413 GIGSYHGKASFDTFSHYKSVLKNAFWLDLDWRY-APYKNK-LSLLKRMMK 460