BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0050.0047.p (473 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ECs3534 [KE] COG1167 Transcriptional regulators containing a DNA... 392 e-109 Z3973 [KE] COG1167 Transcriptional regulators containing a DNA-b... 391 e-108 STM2803 [KE] COG1167 Transcriptional regulators containing a DNA... 369 e-101 RSc0030 [KE] COG1167 Transcriptional regulators containing a DNA... 279 1e-74 alr4738 [KE] COG1167 Transcriptional regulators containing a DNA... 276 9e-74 >ECs3534 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Ecs Escherichia coli O157:H7 Length = 444 Score = 392 bits (1008), Expect = e-109, Method: Compositional matrix adjust. Identities = 209/457 (45%), Positives = 291/457 (63%), Gaps = 17/457 (3%) Query: 19 PLYQQIYDRVRDAITNGVLKPGDRIPSARALANELGLARGTIEAAYSLLAAEGYIEARRQ 78 P YQ I +++ I G LKPG R+PS+R + ELG++R T+E AY+ L A+G++ R Q Sbjct: 2 PRYQDIARQLKTVIEQGKLKPGARLPSSRTWSQELGVSRSTVENAYAELVAQGWLVRRGQ 61 Query: 79 AGTIVSPVLDPQGPIARSAALPTPRADAVSFRPESI--LPFQMGLPALDAFPRKIWARLG 136 AGT VS + PQ +SA D V+F ES LPFQMGLPALD FPR++WAR+ Sbjct: 62 AGTFVSEQIHPQ----QSAV------DVVAFAGESQQPLPFQMGLPALDLFPRELWARVM 111 Query: 137 ARSVRAMQPFDMIHPPVCGLASLRMEIVKYLQIARGISCSPSQVFLTSGYRQSVELIGYA 196 R +R FD+ VCG A+LR IV YL+++RGI C P QVF+T GY S+ LI +A Sbjct: 112 GRRLRTQTRFDLALGDVCGEAALREAIVDYLRVSRGIDCQPEQVFITHGYAASMALILHA 171 Query: 197 LLKAGDGVWLEDPGYPPTREILKYMNIDGVSVPVDEEGIIVSDATKLAPRARAAVVTPAH 256 L + GDG+W+EDPG+P R I+ ++ + VPVD+ G+ V+ + P AR A++TPAH Sbjct: 172 LAQPGDGMWMEDPGFPLIRPIVTRHGVEILPVPVDDNGLDVTSGIQNYPDARFALITPAH 231 Query: 257 QSPLCMSLSLPRRLALLDWAARSKAWIVEDDYDGEYRYVSRPLPALKSLDRDGRVLYAGT 316 QSPL ++LSL RR +L+WA RS+AWI+EDDYD E+RY +PLPALKSLD RV+YAGT Sbjct: 232 QSPLGVALSLARRYQILEWAERSQAWIIEDDYDSEFRYHGKPLPALKSLDAPQRVIYAGT 291 Query: 317 FSKVLFPGIRLAYLVVPLVQVERFTQVIESLSAGSPGLTQTILAAFLSGGHFARHIQRMR 376 FSK LFP +R A+LVVP+ Q+ +F Q P L Q LA F+ GHF RH+++MR Sbjct: 292 FSKALFPALRCAWLVVPVEQISQFRQQASLEPCAVPVLWQNTLADFIREGHFWRHLKKMR 351 Query: 377 KLYAVRREATAAGLESVLGKHVRIDRQPGGMHLILRLRGDRSDRRLVASMRAGGLYAEAL 436 + YA RR+ L + ++ Q GG+ ++++L G+ D V A GL +AL Sbjct: 352 QHYAQRRQWIEQALTQ---QGFQVVPQKGGIQMVIKLAGN--DVTFVHKANAAGLAVQAL 406 Query: 437 TDWTRGRHGVSALLLNFTNIDSQRTAENLGRRILNSM 473 +DW LLL+FTNI S+ A + +++ +++ Sbjct: 407 SDWRIRSSEDGGLLLSFTNIVSESMARQVAQQLRSAL 443 >Z3973 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs EcZ Escherichia coli O157:H7 EDL933 Length = 444 Score = 391 bits (1004), Expect = e-108, Method: Compositional matrix adjust. Identities = 208/457 (45%), Positives = 290/457 (63%), Gaps = 17/457 (3%) Query: 19 PLYQQIYDRVRDAITNGVLKPGDRIPSARALANELGLARGTIEAAYSLLAAEGYIEARRQ 78 P YQ I +++ I G LKPG R+PS+R + ELG++R T+E AY+ L A+G++ R Q Sbjct: 2 PRYQDIARQLKTVIEQGKLKPGARLPSSRTWSQELGVSRSTVENAYAELVAQGWLVRRGQ 61 Query: 79 AGTIVSPVLDPQGPIARSAALPTPRADAVSFRPESI--LPFQMGLPALDAFPRKIWARLG 136 AGT VS + PQ +SA D V+F ES LPFQMGLPALD FPR++WAR+ Sbjct: 62 AGTFVSEQIHPQ----QSAV------DVVAFAGESQQPLPFQMGLPALDLFPRELWARVM 111 Query: 137 ARSVRAMQPFDMIHPPVCGLASLRMEIVKYLQIARGISCSPSQVFLTSGYRQSVELIGYA 196 R +R FD+ VCG A+LR IV YL+++RGI C P QVF+T GY S+ LI + Sbjct: 112 GRRLRTQTRFDLALGDVCGEAALREAIVDYLRVSRGIDCQPEQVFITHGYAASMALILHX 171 Query: 197 LLKAGDGVWLEDPGYPPTREILKYMNIDGVSVPVDEEGIIVSDATKLAPRARAAVVTPAH 256 L + GDG+W+EDPG+P R I+ ++ + VPVD+ G+ V+ + P AR A++TPAH Sbjct: 172 LAQPGDGMWMEDPGFPLIRPIVTRHGVEILPVPVDDNGLDVTSGIQNYPDARFALITPAH 231 Query: 257 QSPLCMSLSLPRRLALLDWAARSKAWIVEDDYDGEYRYVSRPLPALKSLDRDGRVLYAGT 316 QSPL ++LSL RR +L+WA RS+AWI+EDDYD E+RY +PLPALKSLD RV+YAGT Sbjct: 232 QSPLGVALSLARRYQILEWAERSQAWIIEDDYDSEFRYHGKPLPALKSLDAPQRVIYAGT 291 Query: 317 FSKVLFPGIRLAYLVVPLVQVERFTQVIESLSAGSPGLTQTILAAFLSGGHFARHIQRMR 376 FSK LFP +R A+LVVP+ Q+ +F Q P L Q LA F+ GHF RH+++MR Sbjct: 292 FSKALFPALRCAWLVVPVEQISQFRQQASLEPCAVPVLWQNTLADFIREGHFWRHLKKMR 351 Query: 377 KLYAVRREATAAGLESVLGKHVRIDRQPGGMHLILRLRGDRSDRRLVASMRAGGLYAEAL 436 + YA RR+ L + ++ Q GG+ ++++L G+ D V A GL +AL Sbjct: 352 QHYAQRRQWIEQALTQ---QGFQVVPQKGGIQMVIKLAGN--DVTFVHKANAAGLAVQAL 406 Query: 437 TDWTRGRHGVSALLLNFTNIDSQRTAENLGRRILNSM 473 +DW LLL+FTNI S+ A + +++ +++ Sbjct: 407 SDWRIRSSEDGGLLLSFTNIVSESMARQVAQQLRSAL 443 >STM2803 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Sty Salmonella typhimurium LT2 Length = 444 Score = 369 bits (946), Expect = e-101, Method: Compositional matrix adjust. Identities = 203/459 (44%), Positives = 273/459 (59%), Gaps = 21/459 (4%) Query: 19 PLYQQIYDRVRDAITNGVLKPGDRIPSARALANELGLARGTIEAAYSLLAAEGYIEARRQ 78 P YQ I +++ AI G L PG R+PS+R A ELG++R T+E AY L A+G++E R Q Sbjct: 2 PRYQHIARQLKTAIEQGELAPGTRLPSSRTWAQELGVSRATVENAYGELVAQGWLERRGQ 61 Query: 79 AGTIVSPVLD----PQGPIARSAALPTPRADAVSFRPESILPFQMGLPALDAFPRKIWAR 134 AGT VS L P P + P P+ PFQMGLPALD FPR+ WAR Sbjct: 62 AGTFVSNALRFETAPPIPAVFAGESPEPK------------PFQMGLPALDLFPREKWAR 109 Query: 135 LGARSVRAMQPFDMIHPPVCGLASLRMEIVKYLQIARGISCSPSQVFLTSGYRQSVELIG 194 + R +R FD+ VCG A LR IV YL+++R I C P QVF+TSGY S+ LI Sbjct: 110 VMGRRLRTQTCFDLALGDVCGEAILRQAIVDYLRVSRSIECLPEQVFITSGYADSMRLIL 169 Query: 195 YALLKAGDGVWLEDPGYPPTREILKYMNIDGVSVPVDEEGIIVSDATKLAPRARAAVVTP 254 L GD +W+EDPG+P R ++ I +PVD +G+ V+ + P+ R A+VTP Sbjct: 170 RTLSVPGDSMWVEDPGFPLIRPVITQEGITLAPIPVDADGLNVAAGMRDCPQGRFALVTP 229 Query: 255 AHQSPLCMSLSLPRRLALLDWAARSKAWIVEDDYDGEYRYVSRPLPALKSLDRDGRVLYA 314 AHQSPL ++LSL RR LL WAA +AWI+EDDYD E+RY +PLP LKSLD RV+YA Sbjct: 230 AHQSPLGVALSLTRRRQLLAWAANVQAWIIEDDYDSEFRYHGKPLPPLKSLDAPQRVIYA 289 Query: 315 GTFSKVLFPGIRLAYLVVPLVQVERFTQVIESLSAGSPGLTQTILAAFLSGGHFARHIQR 374 GTFSK LFP +R A+LVVP+ Q+E F Q + P L Q LA F+ GHF RH+++ Sbjct: 290 GTFSKSLFPALRTAWLVVPIKQIEHFRQQASLMPCSVPLLWQHTLADFIRDGHFWRHLKK 349 Query: 375 MRKLYAVRREATAAGLESVLGKHVRIDRQPGGMHLILRLRGDRSDRRLVASMRAGGLYAE 434 MR+ YA RR E++ + + Q GG+ L++ + GD D+ VA GL + Sbjct: 350 MRQHYAQRRLWIE---EALAEQGFVVTLQKGGIQLVIEVEGD--DKAQVAKANQAGLAVQ 404 Query: 435 ALTDWTRGRHGVSALLLNFTNIDSQRTAENLGRRILNSM 473 AL+ W G +LL+FTNI S A+ + ++ ++ Sbjct: 405 ALSRWRVVSSGKGGILLSFTNITSAGMAKQVACQLRQAI 443 >RSc0030 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Rso Ralstonia solanacearum Length = 509 Score = 279 bits (713), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 166/421 (39%), Positives = 226/421 (53%), Gaps = 31/421 (7%) Query: 19 PLYQQIYDRVRDAITNGVLKPGDRIPSARALANELGLARGTIEAAYSLLAAEGYIEARRQ 78 P ++++Y +++ I L+PG R+PS+R LA ELG+AR T+ Y L EGY+ A Sbjct: 30 PDHRRLYRMLQEGILRDELQPGTRLPSSRQLAAELGIARNTVIHVYEQLGVEGYVSAGVG 89 Query: 79 AGTIVSPV----LD-----------------PQGPIARSAALPTPRADAVSFRPESILPF 117 +GT V+ LD P P+ S R S R F Sbjct: 90 SGTFVADTVPDRLDAAPPPAAAPVSISEAAMPAAPMLSSRGRALVRDAGASSRQWGA--F 147 Query: 118 QMGLPALDAFPRKIWARLGARSVRAMQPFDMIHPPVCGLASLRMEIVKYLQIARGISCSP 177 G+P + FP + W+RL R +R P + +P G LR + YL+ ARG+ C P Sbjct: 148 MPGVPEVRMFPARTWSRLHNRLLRKPSPALLTYPVGAGYLPLRTALADYLRTARGVRCEP 207 Query: 178 SQVFLTSGYRQSVELIGYALLKAGDGVWLEDPGYPPTREILKYMNIDGVSVPVDEEGIIV 237 Q+ +T+G S++LI L AGD W+EDPGY R +L + V +PVD+EG+ Sbjct: 208 EQIIITAGIHPSLQLIAQLLCDAGDSAWIEDPGYWGVRSVLTAAGVRTVPLPVDDEGMRF 267 Query: 238 SDATKLAPRARA-----AVVTPAHQSPLCMSLSLPRRLALLDWAARSKAWIVEDDYDGEY 292 A + R R VV+P+HQ PL +SL RR LL A + AWIVEDDYD E+ Sbjct: 268 EAAGR---RQRGRPPKLMVVSPSHQYPLGSVMSLARRRQLLATAQATDAWIVEDDYDSEF 324 Query: 293 RYVSRPLPALKSLDRDGRVLYAGTFSKVLFPGIRLAYLVVPLVQVERFTQVIESLSAGSP 352 RY SRPLP+L+ LD GRVLY GTFSKVLFP +R+ YLVVP E F + + G Sbjct: 325 RYGSRPLPSLQGLDEGGRVLYMGTFSKVLFPSLRIGYLVVPPALAEAFATGLSEMFRGGQ 384 Query: 353 GLTQTILAAFLSGGHFARHIQRMRKLYAVRREATAAGLESVLGKHVRIDRQPGGMHLILR 412 LTQ +LA F++ GHF HI+RMR +YA RRE + G+ + + G+HL+L Sbjct: 385 ILTQAVLAEFIAEGHFVSHIRRMRGVYAERRETLLEAIRREFGEALPVHDGASGLHLVLG 444 Query: 413 L 413 L Sbjct: 445 L 445 >alr4738 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Nos Nostoc sp. PCC 7120 Length = 490 Score = 276 bits (705), Expect = 9e-74, Method: Compositional matrix adjust. Identities = 170/483 (35%), Positives = 248/483 (51%), Gaps = 22/483 (4%) Query: 12 LDPAAAAPLYQQIYDRVRDAITNGVLKPGDRIPSARALANELGLARGTIEAAYSLLAAEG 71 +DP A PL++Q+Y+ +R AI G L G ++PS R+LA LG++R T+ Y LL +EG Sbjct: 7 IDPDAPLPLHRQVYEELRRAILLGRLTSGGKLPSTRSLAQLLGVSRATVTQGYELLLSEG 66 Query: 72 YIEARRQAGTIV-----------SPV---LDPQGPIARSAALPTPRADAVSFR-PESI-- 114 Y+E +GT V +P+ L P + +A +D R PE Sbjct: 67 YLETIVGSGTFVCRQLPDELLNTAPIESKLQPSNSLVPLSAYGKSLSDKAFLRIPEQAVE 126 Query: 115 LPFQMGLPALDAFPRKIWARLGARSVRAMQPFDMIHPPVCGLASLRMEIVKYLQIARGIS 174 + F G PA D FP +W +L +R + G LR I YL +R ++ Sbjct: 127 ISFSYGRPAFDQFPIDLWRKLISRHCHSKAEVLDYTDNSLGYQPLREAIAAYLSRSRAVN 186 Query: 175 CSPSQVFLTSGYRQSVELIGYALLKAGDGVWLEDPGYPPTREILKYMNIDGVSVPVDEEG 234 C Q+ + G +Q ++LI L+ DG+ +E+PGY R VPVD+ G Sbjct: 187 CQAEQIIIVGGSQQGLDLITRILIDPNDGIAVEEPGYLGARRAFLAQGASLFPVPVDQSG 246 Query: 235 IIVSD-ATKLAPRARAAVVTPAHQSPLCMSLSLPRRLALLDWAARSKAWIVEDDYDGEYR 293 +IVS T + P+ + VTP+HQ P LSLPRRL LL WA ++ I+EDDYD EYR Sbjct: 247 LIVSKLTTGIIPKLKLIYVTPSHQFPTGAVLSLPRRLELLAWAHKTGVMIIEDDYDSEYR 306 Query: 294 YVSRPLPALKSLDRDGRVLYAGTFSKVLFPGIRLAYLVVPLVQVERFTQVIESLSAGSPG 353 Y RP+PAL+ LD+ V+Y GTFSKVLFP +RL YLV+P V F + Sbjct: 307 YGERPIPALQGLDQGNSVVYVGTFSKVLFPALRLGYLVLPQNLVNIFARAKWLADRQCSL 366 Query: 354 LTQTILAAFLSGGHFARHIQRMRKLYAVRREATAAGLESVLGKHVRIDRQPGGMHLILRL 413 L Q L F++ GH RHI+RMR LY RR+ L S G +I + GMHL++++ Sbjct: 367 LEQYALTDFITEGHLERHIRRMRSLYNQRRQTLVQSLFSHFGNRAKILGENAGMHLMVKI 426 Query: 414 RGDRSDRRLVASMRAGGL-YAEALTDWTRGRHGVSALLLNFTNIDSQRTAENLGR--RIL 470 SD +V S G+ A + + G S + + ++ Q+ E + R R++ Sbjct: 427 DTQISDDEIVQSADLSGVSIGAAYPQYLKDSPG-SEFIFGYAELNEQQIQEGVRRLARVI 485 Query: 471 NSM 473 +++ Sbjct: 486 HNL 488