BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0043.0035.p (228 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mll0909 Non COG 191 1e-48 SMc01704 [O] COG2020 Putative protein-S-isoprenylcysteine methyl... 168 1e-41 MA2467 [O] COG2020 Putative protein-S-isoprenylcysteine methyltr... 132 7e-31 MA0734 [O] COG2020 Putative protein-S-isoprenylcysteine methyltr... 111 2e-24 Rv1216c [O] COG2020 Putative protein-S-isoprenylcysteine methylt... 105 8e-23 >mll0909 Non COG Length = 244 Score = 191 bits (484), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 102/210 (48%), Positives = 131/210 (62%), Gaps = 4/210 (1%) Query: 22 LGTFLFLAAGTLRWAGAWVFLLEITIGGLITEAWLARHDPGLLAERRTA---RGQAGWDR 78 +G LFL+AGT W AWV+L+ + L LAR DPGL+ ER +A + QA D+ Sbjct: 36 MGALLFLSAGTFAWPAAWVYLVVMVGLSLTMGVALARRDPGLMNERLSAPIQKNQAAADK 95 Query: 79 VITMIMPLLWLTWLPLMALDAVRYQTSIAPFWLQCAGAAMIAASFYIVYRTYRENSYAAP 138 V+ I+ + WL M D R+ S PFW Q GA ++ +I Y T ENS+AAP Sbjct: 96 VLLSILLIGIFGWLSFMGFD-FRFGWSAVPFWAQAVGALVLLVGIWICYLTMLENSFAAP 154 Query: 139 VVKIQRERGHAAVTTGPYAYVRHPIYASGLLTYVGTPLLLGSWYGLAIVPVMAALLGLRS 198 VVKIQ ERG +TTGPY+YVRHP+YA +L + GT LLLGSW+GL V V LL +R+ Sbjct: 155 VVKIQDERGQRVITTGPYSYVRHPMYAGAILFFAGTALLLGSWWGLVSVLVFIVLLAIRT 214 Query: 199 LMEERMLTAELDGYAEYLARVRYRLVPMVW 228 +EE+ L L GY +Y RVRYRL+PMVW Sbjct: 215 FIEEKTLRTGLRGYDDYATRVRYRLIPMVW 244 >SMc01704 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase Sme Sinorhizobium meliloti Length = 225 Score = 168 bits (425), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 99/210 (47%), Positives = 125/210 (59%), Gaps = 3/210 (1%) Query: 22 LGTFLFLAAGTLRWAGAWVFLLEITIGGLITEAWLARHDPGLLAERRTA---RGQAGWDR 78 +G LFL+AGTL W AW +L + + LARHDP LL ER A GQ D+ Sbjct: 16 IGAVLFLSAGTLAWPAAWTYLFLMLALSFLVGLLLARHDPALLKERLAAPIQEGQPLADK 75 Query: 79 VITMIMPLLWLTWLPLMALDAVRYQTSIAPFWLQCAGAAMIAASFYIVYRTYRENSYAAP 138 V+ ++ L + MALDA R++ S P W+Q GA ++ S YRT RENS+A+P Sbjct: 76 VLLSVILLFLVGGFAFMALDAARFKWSSMPVWVQALGALLVVLSIGFSYRTLRENSFASP 135 Query: 139 VVKIQRERGHAAVTTGPYAYVRHPIYASGLLTYVGTPLLLGSWYGLAIVPVMAALLGLRS 198 VVK+Q ER + +TTGPY YVRHP Y LL T L LGSW+GL + +AALL +R Sbjct: 136 VVKVQTERAQSVITTGPYRYVRHPFYTGSLLFVAATSLFLGSWWGLLVALGLAALLAIRI 195 Query: 199 LMEERMLTAELDGYAEYLARVRYRLVPMVW 228 +EE+ L L GY Y RVRYRLVP VW Sbjct: 196 GIEEKALRTGLAGYDAYAERVRYRLVPYVW 225 >MA2467 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase Mac Methanosarcina acetivorans str.C2A Length = 237 Score = 132 bits (331), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 77/214 (35%), Positives = 127/214 (59%), Gaps = 10/214 (4%) Query: 20 VGLGTFLFLAAGTLRWAGAWVFLLEITIGGLITEAWLARHDPGLLAERRTARG----QAG 75 V LG LF A + + AWV+L+ ++ +L + DP LL ERR RG + Sbjct: 29 VMLGICLFGPAWSFDFWQAWVYLIVFYGSVVMITIYLWKKDPKLL-ERRVERGPGAEKEK 87 Query: 76 WDRVITMIMPLLWLTWLPLMALDAVRYQTSIAPFWLQCAGAAMIAASFYIVYRTYRENSY 135 ++I + + +L+ L + + D R+ S P ++ AG ++ +++++ +REN + Sbjct: 88 TQKIIQLFLLILFCAILIIPSFDH-RFGWSDVPVYIVIAGDMLVVLGYFLIFLVFRENPF 146 Query: 136 AAPVVKIQRERGHAAVTTGPYAYVRHPIYASGLLTYVGTPLLLGSWYGLAI-VPVMAALL 194 AA +++ ++ +TTG Y+ VRHP+YA+GL+ + GTPL LGSW+GL I VP+M ++ Sbjct: 147 AAATIQVSSDQ--QVITTGVYSIVRHPMYAAGLIIFSGTPLALGSWWGLLILVPIMLVII 204 Query: 195 GLRSLMEERMLTAELDGYAEYLARVRYRLVPMVW 228 R L EE+ L+ L GY EY +VRYRL+P++W Sbjct: 205 W-RLLEEEKFLSENLPGYKEYCQKVRYRLIPLLW 237 >MA0734 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase Mac Methanosarcina acetivorans str.C2A Length = 233 Score = 111 bits (277), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 75/222 (33%), Positives = 112/222 (50%), Gaps = 7/222 (3%) Query: 13 RRASFTCVGLGTFL---FLAAGTLRWAGAWVFLLEITIGGLITEAWLARHDPGLL-AERR 68 RRAS GL F+ FL+AG + AW F + L R +P ++ A Sbjct: 13 RRASQVIAGLLLFMVVFFLSAGRIDLPRAWFFFAIYFVSFLFNTVIFLRFNPEIIRARSE 72 Query: 69 TARGQAGW-DRVITMIMPLLWLTWLPLMALDAVR-YQTSIAPFWLQCAGAAMIAASFYIV 126 T G+ W D+V ++ + + + LD R + +SI +L + + V Sbjct: 73 TNWGKMKWWDKVFAVLYFVFLFSMFIVCGLDVGRLHLSSIGIGFLVVGVIIFVVGWAFAV 132 Query: 127 YRTYRENSYAAPVVKIQRERGHAAVTTGPYAYVRHPIYASGLLTYVGTPLLLGSWYGLAI 186 + EN + V++Q ER H V+TGPYA +RHP YA +L Y +P ++GS YGL Sbjct: 133 WAMV-ENKFFETTVRVQMEREHRVVSTGPYAIIRHPGYAGMILFYGCSPFIIGSLYGLIP 191 Query: 187 VPVMAALLGLRSLMEERMLTAELDGYAEYLARVRYRLVPMVW 228 V ++A R+ E+R+L EL GY EY +V+YRL+P VW Sbjct: 192 VILLAFAFVFRTYFEDRLLYEELTGYKEYTKKVKYRLLPFVW 233 >Rv1216c [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase Mtu Mycobacterium tuberculosis H37Rv Length = 224 Score = 105 bits (262), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 81/215 (37%), Positives = 108/215 (50%), Gaps = 12/215 (5%) Query: 20 VGLGTFLFLAAGTLRWAGAWVFL---LEITIGGLITEAWLARHDPGLLAERRTARGQAGW 76 V G LF AGT + AWVFL + TIG I +LAR+DP L +RR G Sbjct: 16 VVFGALLFGPAGTFDYWQAWVFLAAFVSTTIGPTI---YLARNDPAAL-QRRMRSGPLAE 71 Query: 77 DRVITMIMPL-LWLTWLPLMALDAV--RYQTSIAPFWLQCAGAAMIAASFYIVYRTYREN 133 R I + + +L + +M L A RY S P + G ++ I +N Sbjct: 72 GRTIQKFIVIGAFLGFFAMMVLSACDHRYGWSSVPAAVCVIGDVLVMTGLGIAMLVVIQN 131 Query: 134 SYAAPVVKIQRERGHAAVTTGPYAYVRHPIYASGLLTYVGTPLLLGSWYGLAIVPVMAAL 193 YAA V++ E G + G Y VRHP+YA ++ G PL LGS++ + I+ + Sbjct: 132 RYAASTVRV--EAGQILASDGLYKIVRHPMYAGNVVMMTGIPLALGSYWAMFILVPGTLV 189 Query: 194 LGLRSLMEERMLTAELDGYAEYLARVRYRLVPMVW 228 L R L EE++LT EL GY EY VRYRLVP VW Sbjct: 190 LVFRILDEEKLLTQELSGYREYRQLVRYRLVPYVW 224