BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0043.0003.p (288 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value FN1868 [S] COG3246 Uncharacterized conserved protein Fnu Fusobac... 155 1e-37 AF1210 [S] COG3246 Uncharacterized conserved protein Afu Archaeo... 127 2e-29 mll0106 Non COG 127 2e-29 Rv1718 [S] COG3246 Uncharacterized conserved protein Mtu Mycobac... 107 3e-23 PA5387 [S] COG3246 Uncharacterized conserved protein Pae Pseudom... 106 5e-23 >FN1868 [S] COG3246 Uncharacterized conserved protein Fnu Fusobacterium nucleatum Length = 272 Score = 155 bits (391), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 101/295 (34%), Positives = 156/295 (52%), Gaps = 30/295 (10%) Query: 1 MSDKAVITCALNGVLTDPKQHN--VPVTPEQMAREARAAFNAGASIMHIHLRQQEPNKGH 58 M +K +IT A+ G K+HN VP T E++AREA +A+ AGASI+H+H+R+ + Sbjct: 1 MMEKLIITAAICGAEV-TKEHNPAVPYTVEEIAREAESAYKAGASIIHLHVREDDGT--- 56 Query: 59 LPSWDVGVSKEIQQAIREACPGVIINHTTGTSGPNYQGALDCVR----ETRPEIAACNAG 114 P+ D ++ +AIRE CP VII +TG + G D R E PE+A + G Sbjct: 57 -PTQDKERFRKCIEAIREKCPDVIIQPSTGGA----VGMTDLERLQPTELHPEMATLDCG 111 Query: 115 SLNYLKVKADNTWAWPPMMFDNAVEKVQDYLDVMKAAGTIPEFECFDVGIVRCVGMYRQT 174 + N+ +F N ++++ ++ G PE E FD G++ Y++ Sbjct: 112 TCNF----------GGDEIFVNTENTIKNFGKILIERGVKPEIEVFDKGMIDYAIRYQKQ 161 Query: 175 GMYSGPLEYNFVMGVASGMPADPELLPILLRLKAPE-AHWQVTAIGRAEIWPLHQRAADL 233 G P+ ++FV+GV M A L + + PE + W V +GR + + + A + Sbjct: 162 GFIQKPMHFDFVLGVQ--MSASARDL-VFMSESIPEGSTWTVAGVGRHQ-FQMAALAIVM 217 Query: 234 GGHLRSGLEDTFYLGDGTKVTSNGQLVEGLAACARRAGREIASPAEARQIFGVRQ 288 GGH+R G ED Y+ G SNG+LVE + A+ GREIA+P EARQI +++ Sbjct: 218 GGHVRVGFEDNVYIDKGILAKSNGELVERVVRLAKELGREIATPDEARQILSLKK 272 >AF1210 [S] COG3246 Uncharacterized conserved protein Afu Archaeoglobus fulgidus Length = 313 Score = 127 bits (320), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 97/309 (31%), Positives = 149/309 (48%), Gaps = 29/309 (9%) Query: 2 SDKAVITCALNGVLTDPKQH-NVPVTPEQMAREARAAFNAGASIMHIHLRQQEPNKGHLP 60 D ++TCA+ G + P +PVTP+Q+ EA A AGA ++HIH R +P G P Sbjct: 4 DDVVIVTCAITGAIHTPSMSPYLPVTPDQIVEEAVKAAEAGAGMVHIHAR--DPKDGR-P 60 Query: 61 SWDVGVSKEIQQAIREACPGVIINHTTGTSG----PNYQGALDCVRETRPEIAACNAGSL 116 + DV V + I + I++ V+IN TTG G P + A V +PEIA N GS+ Sbjct: 61 TTDVEVFRYICREIKKQS-DVVINVTTGGGGTLGIPVEERA-KVVPALKPEIATFNMGSM 118 Query: 117 NY-----LKVKADNTWAWPP--------MMFDNAVEKVQDYLDVMKAAGTIPEFECFDVG 163 N+ LK + + W P ++F N + ++ + K T PE EC+D+G Sbjct: 119 NFAIHPLLKKYKEFKYDWEPEYLEMTRDIVFRNTFKDLEALSRIFKENDTKPELECYDIG 178 Query: 164 IVRCVGMYRQTGMYSGPLEYNFVMGVASGMPADPELLPILL----RLKAPEAH-WQVTAI 218 + G PL F+ G+ G+ E + + RL E + W + Sbjct: 179 QIYNTAFMFHEGYLEPPLRLQFIHGILGGIGTAVEDVLFMKQTADRLIGRENYTWSLVGA 238 Query: 219 GRAEIWPLHQRAADLGGHLRSGLEDTFYLGDGTKVTSNGQLVEGLAACARRAGREIASPA 278 GR ++ PL A +GG +R GLED+ Y+ G SN + VE + + G+ A+P Sbjct: 239 GRFQM-PLGTLAVIMGGDVRVGLEDSLYIERGKLAKSNAEQVEKMVRIVKELGKRPATPD 297 Query: 279 EARQIFGVR 287 E R+I G++ Sbjct: 298 EVREILGLK 306 >mll0106 Non COG Length = 309 Score = 127 bits (320), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 103/304 (33%), Positives = 154/304 (50%), Gaps = 26/304 (8%) Query: 4 KAVITCALNGVLTDPKQH-NVPVTPEQMAREARAAFNAGASIMHIHLRQQEPNKGHLPSW 62 K +ITCA+ G + P +PVTP+Q+A +A AA AGASI+H+H R +P G P+ Sbjct: 5 KVIITCAVTGSVHTPSMSPYLPVTPDQIASDAIAAAEAGASILHLHAR--DPKDGR-PTA 61 Query: 63 DVGVSKEIQQAIREACPGVIINHTTGTSGPNYQGALDCVRETRPEIAACNAGSLNYL--- 119 D V + I++A VI T G+S L PE+ + N GS+N+ Sbjct: 62 DPDVFMQFLPRIKQATDAVINITTGGSSLMTLDQRLAAPLRAEPEMCSLNMGSMNFALFP 121 Query: 120 KVKADNTW--AWPPMM--------FDNAVEKVQDYLDVM-KAAGTIPEFECFDVGIVRCV 168 + W W P + F N ++ L+ + K GT EFEC+DVG + + Sbjct: 122 MLDKPREWQHEWEPKLLEATRDTIFKNTFADMEGVLERLGKGCGTRFEFECYDVGHLYSL 181 Query: 169 GMYRQTGMYSGPLEYNFVMGVASGMPADPELLPILLR----LKAPEAHWQVTAIGRAEIW 224 +R G+ SGPL FV+G+ G+ ADP+ L + R L + V A GR ++ Sbjct: 182 AHFRDRGLVSGPLFIQFVLGILGGIGADPDNLVHMKRIADKLFGDSYQFSVLAAGRQQM- 240 Query: 225 PLHQRAADLGGHLRSGLEDTFYLGDGTKVT-SNGQLVEGLAACARRAGREIASPAEARQI 283 PL AA +GG++R GLED+ Y DG ++ SN V + E+A+PAEAR++ Sbjct: 241 PLISIAAAMGGNVRVGLEDSLY--DGRQLAKSNADQVRRIRGILDGLSLEVATPAEAREM 298 Query: 284 FGVR 287 ++ Sbjct: 299 LALK 302 >Rv1718 [S] COG3246 Uncharacterized conserved protein Mtu Mycobacterium tuberculosis H37Rv Length = 272 Score = 107 bits (267), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 86/277 (31%), Positives = 132/277 (47%), Gaps = 20/277 (7%) Query: 6 VITCALNG-VLTDPKQHNVPVTPEQMAREARAAFNAGASIMHIHLRQQEPNKGHLPSWDV 64 VIT A G + T +P +PE++A A++AGA++ HIHLR ++ P+ D Sbjct: 4 VITVAPTGPIATKADNPALPTSPEEIATAVEQAYHAGAAVAHIHLR----DENERPTADP 59 Query: 65 GVSKEIQQAIREACPGVIINHTTGTSGPNYQGALDCVRETRPEIAACNAGSLNYLKVKAD 124 +++ I E CP ++I +TG + + E RP +A N S+++ + Sbjct: 60 NIARRAMDLIGERCP-ILIQLSTGVGLTVPFEQREQLVELRPRMATLNPCSMSFGAGE-- 116 Query: 125 NTWAWPPMMFDNAVEKVQDYLDVMKAAGTIPEFECFDVG-IVRCVGMYRQTGMYSGPLEY 183 F N + V+ M+ PE E +D G + C+ ++ + + + PL++ Sbjct: 117 ---------FRNPPQAVRRLAARMRELDIKPELEIYDTGHLEACLRLWAE-DLLAEPLQF 166 Query: 184 NFVMGVASGMPADPELLPILLRLKAPEAHWQVTAIGRAEIWPLHQRAADLGGHLRSGLED 243 + V+GV GM A + L ++R P A WQV AIG+A + L LGG+ R GLED Sbjct: 167 SIVLGVRGGMAATADNLLTMVRRLPPGAIWQVIAIGKANME-LTAMGLALGGNARVGLED 225 Query: 244 TFYLGDGTKVTSNGQLVEGLAACARRAGREIASPAEA 280 T YL G SN LV A IAS EA Sbjct: 226 TLYLRKGELAPSNLALVSRTIRLAEALDLPIASVEEA 262 >PA5387 [S] COG3246 Uncharacterized conserved protein Pae Pseudomonas aeruginosa Length = 294 Score = 106 bits (265), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 93/307 (30%), Positives = 139/307 (45%), Gaps = 35/307 (11%) Query: 1 MSDKAVITCALNGVLTDPKQH-NVPVTPEQMAREARAAFNAGASIMHIHLRQQEPNKGHL 59 M+ + ++TCA+ G +H +PVTP+Q+A A A AGA++ H H+R K Sbjct: 1 MNHEVIVTCAVTGAGDTVGRHPAIPVTPKQIAEAAIEAARAGATVAHCHVRDPATGK--- 57 Query: 60 PSWDVGVSKEIQQAIREACPGVIINHTTGT----------------SGPNYQGALDCVR- 102 PS DV + +E+ + IRE+ VIIN T G +G + G L+ +R Sbjct: 58 PSRDVALYREVVERIRESDTDVIINLTAGMGGDLEIGKGEQPLEFGAGTDLVGPLERLRH 117 Query: 103 --ETRPEIAACNAGSLNYLKVKADNTWAWPPMMFDNAVEKVQDYLDVMKAAGTIPEFECF 160 E PEI + G+LN+ D + P ++ + G E E F Sbjct: 118 VEELLPEICTLDCGTLNF--GDGDYIYVSTPAQLRAGARRITEL-------GVKAELEIF 168 Query: 161 DVGIVRCVGMYRQTGMYSGPLEYNFVMGVASGMPADPELLPILLRLKAPEAHWQVTAIGR 220 D G + + G+ PL + +G+ G PAD + + P A W IGR Sbjct: 169 DTGHLWFAKQMLKEGLLEDPL-FQICLGIPWGAPADTTTMKAMADNLPPGATWAGFGIGR 227 Query: 221 AEIWPLHQRAADLGGHLRSGLEDTFYLGDGTKVTSNGQLVEGLAACARRAGREIASPAEA 280 ++ P+ +A LGG++R GLED +L G SNG LVE R G SPAE Sbjct: 228 TQM-PMVAQAMLLGGNVRVGLEDNIWLDKGVP-ASNGSLVERAIEIIERLGGRALSPAEG 285 Query: 281 RQIFGVR 287 R+ ++ Sbjct: 286 RRRMNLK 292