BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0041.0053.p (442 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 328 2e-89 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 321 2e-87 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 310 6e-84 RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 295 1e-79 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 295 1e-79 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 328 bits (840), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 172/413 (41%), Positives = 256/413 (61%), Gaps = 4/413 (0%) Query: 8 ELEQQTIRRVYWRLIPILFVMMFFNYLDRINLGYAGLTMNKDLGLSPAIFGFAASIFFLG 67 + E R+ W L+P+L + NYLDR+N+G+A L M DL S ++G A +FF+G Sbjct: 16 QEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGAGMFFIG 75 Query: 68 YMVLEVPSNLMLHWLGARIWLARILITWGLVAALTAFVWNPLSLYVMRFGLGVAEAGFMP 127 Y LE+PSNL+LH +GAR+W+ARI+ITWG+++A AFV P+S YVMRF LGVAEAGF P Sbjct: 76 YFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLLGVAEAGFFP 135 Query: 128 GVVLYLTYWFPARYRARAVAGYIIAGSFSAVLGGPISTSIMTWFDGTAGLHGWQWMFLAE 187 G++LY++YWFP+ R R ++I+ S ++G P+S IM +F+G G GWQWMF+ E Sbjct: 136 GIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYAGWQWMFILE 195 Query: 188 GVPTILFGLFTLYYLTDRPAKASWLTKEQAAWLEGELAAERAEIEQQGQHRLIECVLDIR 247 G+P++L G+ +Y L DR A+WLT ++ L+ + E A RL + L R Sbjct: 196 GIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAA---HYAHSRLRDAFLQPR 252 Query: 248 VWLLAALFGCALVGIYGLLLWLPQIIKGMGNLSNIQVGFLSAIPPLLGVIGTIVVSRSSD 307 VWLL ++ C + G Y + WLP +I+ G + +GFL+AIP + IVVSRS+D Sbjct: 253 VWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVSRSAD 312 Query: 308 KTGDRKFHLAAVYLLAAVAMLGSAYVASP-VLAFVFLCIVGFSLNAGNPLFWSINASLLT 366 + +R++HLA +L AV ++ S Y + V+A V L I + PLFWS+ + L Sbjct: 313 RLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLFWSLPTAFLG 372 Query: 367 GAAGAASIALVNTLAQFGGLIGPWCIGLIKDSTGSFSWALVGIAGFLLVASAI 419 G+A AA IA +N+ GG + P+ +G +KD T S + ++ I+ L + +A+ Sbjct: 373 GSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIGAAL 425 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 321 bits (822), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 169/411 (41%), Positives = 261/411 (63%), Gaps = 2/411 (0%) Query: 9 LEQQTIRRVYWRLIPILFVMMFFNYLDRINLGYAGLTMNKDLGLSPAIFGFAASIFFLGY 68 +E T R+V +R+IP+L + YLDR+N+G+A L M+++LG S AI+G A +FF+GY Sbjct: 32 VENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAGLFFIGY 91 Query: 69 MVLEVPSNLMLHWLGARIWLARILITWGLVAALTAFVWNPLSLYVMRFGLGVAEAGFMPG 128 E+PSN++LH LGAR+W+ARI+ITWGL++AL AFV Y++RF LG AEAGF PG Sbjct: 92 FFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLGAAEAGFYPG 151 Query: 129 VVLYLTYWFPARYRARAVAGYIIAGSFSAVLGGPISTSIMTWFDGTAGLHGWQWMFLAEG 188 V+LYLTYWFP+ R A + + + G P+S IM F TAG GWQWMF+ E Sbjct: 152 VILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQWMFVLEA 211 Query: 189 VPTILFGLFTLYYLTDRPAKASWLTKEQAAWLEGELAAERAEIEQQGQHRLIECVLDIRV 248 +P ++ G+ L YL + A WLT+E+ A + ++ A+ + H L+ V + + Sbjct: 212 IPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSK--GKAASHSLMSLVKNPML 269 Query: 249 WLLAALFGCALVGIYGLLLWLPQIIKGMGNLSNIQVGFLSAIPPLLGVIGTIVVSRSSDK 308 W++ ++ C ++G +GL LW+P +I+ G SN+ +G L AIP + +I ++ SRS+D Sbjct: 270 WVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIFSRSADH 329 Query: 309 TGDRKFHLAAVYLLAAVAMLGSAYVASPVLAFVFLCIVGFSLNAGNPLFWSINASLLTGA 368 +R++HL LL AV + +A + ++ +FL + + A PLFWS+ ++L+GA Sbjct: 330 YRERRWHLVVPALLGAVGFVVAASATNTTVSIIFLSMAAAGVLACAPLFWSLPTAILSGA 389 Query: 369 AGAASIALVNTLAQFGGLIGPWCIGLIKDSTGSFSWALVGIAGFLLVASAI 419 A AA IAL+N++A G I P+ +G+I+D+T S + +AGFL++ +AI Sbjct: 390 AAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGAAI 440 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 310 bits (793), Expect = 6e-84, Method: Compositional matrix adjust. Identities = 172/398 (43%), Positives = 249/398 (62%), Gaps = 4/398 (1%) Query: 5 SVTELEQQTIRRVYWRLIPILFVMMFFNYLDRINLGYAGLTMNKDLGLSPAIFGFAASIF 64 S + E+ T R+V WRLIP L + YLDR+N+G+A L M DL S ++G A IF Sbjct: 19 SASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETVYGLGAGIF 78 Query: 65 FLGYMVLEVPSNLMLHWLGARIWLARILITWGLVAALTAFVWNPLSLYVMRFGLGVAEAG 124 F+GY + EVPSN++LH +GAR+W+ARI+I+WGL++A FV P YVMRF LG+AEAG Sbjct: 79 FIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRFLLGLAEAG 138 Query: 125 FMPGVVLYLTYWFPARYRARAVAGYIIAGSFSAVLGGPISTSIMTWFDGTAGLHGWQWMF 184 F PG++LYLTYW+PA R R ++ A + S V+GGPIS + F G GL GWQWMF Sbjct: 139 FFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGWQWMF 198 Query: 185 LAEGVPTILFGLFTLYYLTDRPAKASWLTKEQAAWLEGELAAERAEIEQQGQHRLIECVL 244 L EG+P+++ GL L YL +R + A WLT E+ A L +AAE A+ E + + Sbjct: 199 LIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKEDA---PIAAIMA 255 Query: 245 DIRVWLLAALFGCALVGIYGLLLWLPQIIKGMGNLSNIQVGFLSAIPPLLGVIGTIVVSR 304 RVWL++ ++ ++G+YG+ WLP +IK G + VG L+AIP V+ ++V+R Sbjct: 256 SPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMVLVAR 315 Query: 305 SSDKTGDRKFHLAAVYLLAAVAMLGSA-YVASPVLAFVFLCIVGFSLNAGNPLFWSINAS 363 S+D+T +R++H+A L A+ ++ SA + + LA L + + PLFWS+ + Sbjct: 316 SADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWSLPTA 375 Query: 364 LLTGAAGAASIALVNTLAQFGGLIGPWCIGLIKDSTGS 401 L G AA IAL+N+L G + P+ +G +KD+T S Sbjct: 376 FLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRS 413 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 295 bits (756), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 164/395 (41%), Positives = 231/395 (58%), Gaps = 6/395 (1%) Query: 10 EQQTIRRVYWRLIPILFVMMFFNYLDRINLGYAGLTMNKDLGLSPAIFGFAASIFFLGYM 69 E+ +R++ WR++P +F + +YLDR N+GYA L MN++L LS FGF + IFF+GY Sbjct: 26 ERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFFIGYF 85 Query: 70 VLEVPSNLMLHWLGARIWLARILITWGLVAALTAFVWNPLSLYVMRFGLGVAEAGFMPGV 129 + EVPSNLML+ GAR W+ARIL+TWGLVA +AFV + LY +RF LGVAEAGF PG+ Sbjct: 86 LFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLGVAEAGFFPGI 145 Query: 130 VLYLTYWFPARYRARAVAGYIIAGSFSAVLGGPISTSIMTWFDGTAGLH--GWQWMFLAE 187 ++YLTYWF AR A VA + A S V+G P+ST IM D L GW+WM L E Sbjct: 146 IVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWIM---DHVHWLQWSGWRWMLLLE 202 Query: 188 GVPTILFGLFTLYYLTDRPAKASWLTKEQAAWLEGELAAERAEIEQQGQHRLIECVLDIR 247 G P ++ GL YL DRP A WL++ + WL EL +R ++ + R Sbjct: 203 GAPAVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERDRKARPAAAHLATLKVMTHPR 262 Query: 248 VWLLAALFGCALVGIYGLLLWLPQIIKGMGN-LSNIQVGFLSAIPPLLGVIGTIVVSRSS 306 V LA ++ G G+ W+PQIIKG + LS+ +VG ++ +P + I SR S Sbjct: 263 VLYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMIWWSRRS 322 Query: 307 DKTGDRKFHLAAVYLLAAVAMLGSAYVASPVLAFVFLCIVGFSLNAGNPLFWSINASLLT 366 D +R+ H A +AA+A +G+ ++ P +A L + L A FW++ LT Sbjct: 323 DLRAERRLHSAVPLGVAALAFVGAGFIGHPAVAMAMLSLSLAGLYAFKSPFWALPTLFLT 382 Query: 367 GAAGAASIALVNTLAQFGGLIGPWCIGLIKDSTGS 401 + A SIA++N++ GG +GP+ IG K S Sbjct: 383 RSTAAVSIAVINSVGNLGGFVGPFAIGYFKGQMHS 417 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 295 bits (755), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 166/384 (43%), Positives = 226/384 (58%), Gaps = 4/384 (1%) Query: 20 RLIPILFVMMFFNYLDRINLGYAGLTMNKDLGLSPAIFGFAASIFFLGYMVLEVPSNLML 79 R++P L F YLDRIN+G+A L M DL LS A +G A IFF GYM+ EVPSNL+L Sbjct: 26 RILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDAAYGLGAGIFFFGYMLFEVPSNLLL 85 Query: 80 HWLGARIWLARILITWGLVAALTAFVWNPLSLYVMRFGLGVAEAGFMPGVVLYLTYWFPA 139 +GAR L+RILI WG+V+A FV + + Y +RF LGV EAGF PG++ YLT W+P Sbjct: 86 VKIGARRTLSRILILWGIVSASMLFVTDVWTFYALRFLLGVFEAGFAPGMIYYLTQWYPG 145 Query: 140 RYRARAVAGYIIAGSFSAVLGGPISTSIMTWFDGTAGLHGWQWMFLAEGVPTILFGLFTL 199 ARA+A + A V+GGP ST IM F G GL GWQWMFLAEG+P+IL G+ Sbjct: 146 ERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAGGLAGWQWMFLAEGIPSILLGIAAY 205 Query: 200 YYLTDRPAKASWLTKEQAAWLEGELAAERAEIEQQGQHRLIECVLDIRVWLLAALFGCAL 259 YL D+PA A WLT Q A + G++A RA Q + + + ++++LAA + C + Sbjct: 206 GYLVDKPADARWLTDAQKAVIAGDIA--RAAPGQASSFG--KALTEPKLYVLAAAYFCLI 261 Query: 260 VGIYGLLLWLPQIIKGMGNLSNIQVGFLSAIPPLLGVIGTIVVSRSSDKTGDRKFHLAAV 319 G+Y + WLP I+K G Q+G SAIP L ++ + R SD+ G+R H A Sbjct: 262 CGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAMIVAMYALGRRSDRRGERHLHSAIT 321 Query: 320 YLLAAVAMLGSAYVASPVLAFVFLCIVGFSLNAGNPLFWSINASLLTGAAGAASIALVNT 379 +L A + +AY S A + + + ++ A +FW+I L G A A IAL+N+ Sbjct: 322 AVLGAGLLAWAAYATSFPAALISITLASAAIFASYSVFWAIPQQHLKGTAAAGGIALINS 381 Query: 380 LAQFGGLIGPWCIGLIKDSTGSFS 403 + FGG P IG K++TGS Sbjct: 382 IGLFGGFFSPTLIGWTKEATGSLQ 405