BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0040.0024.p (443 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BU425_2 [H] COG0007 Uroporphyrinogen-III methylase Buc Buchnera ... 199 1e-50 YPO3367_2 [H] COG0007 Uroporphyrinogen-III methylase Ype Yersini... 194 5e-49 PA2611_2 [H] COG0007 Uroporphyrinogen-III methylase Pae Pseudomo... 187 6e-47 YPO0158_2 [H] COG0007 Uroporphyrinogen-III methylase Ype Yersini... 182 1e-45 STM3477_2 [H] COG0007 Uroporphyrinogen-III methylase Sty Salmone... 180 5e-45 >BU425_2 [H] COG0007 Uroporphyrinogen-III methylase Buc Buchnera sp. APS Length = 259 Score = 199 bits (506), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 98/189 (51%), Positives = 129/189 (68%) Query: 224 GHVTLVGAGPGDPDLLTVKALRALQDADVVFYDELVSPEILDRIRRDATRIPVGRRVGKP 283 G + LVGAGPGD LLT++ L+ LQ ADVV YD LVS +ILD IRRDA RI VG+RVG Sbjct: 1 GEIILVGAGPGDSGLLTLRGLQVLQQADVVLYDYLVSEDILDLIRRDAKRICVGKRVGLK 60 Query: 284 GIGQDAINALMIEAAQSGQRAVRLKGGDSFIFGRGGEEIEALRDAGVAYSIIPGVSAGLG 343 I Q+ I L+I AQ G++ VRLKGGD FIFGRG EEIEA +DAG+ + ++PG+++ +G Sbjct: 61 NITQNEIIKLLIFFAQKGKKVVRLKGGDPFIFGRGSEEIEAAKDAGIHFQVVPGITSAIG 120 Query: 344 AAAQFEVPLTFRHEALRITFLTAHKARDAEVVDWSVLTDKKMTVVVYMGMTAAPSIREGM 403 AA +PLT R + + F+T HK D + +WS+L+D T+VVYMG A I + + Sbjct: 121 IAAYTGIPLTHRKYSQGVIFITGHKCIDGFLNNWSILSDPSYTLVVYMGTLKAVYIAQKL 180 Query: 404 LAAGRSPET 412 + GRS T Sbjct: 181 ITFGRSKLT 189 >YPO3367_2 [H] COG0007 Uroporphyrinogen-III methylase Ype Yersinia pestis Length = 268 Score = 194 bits (492), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 96/194 (49%), Positives = 131/194 (67%) Query: 219 EGKAIGHVTLVGAGPGDPDLLTVKALRALQDADVVFYDELVSPEILDRIRRDATRIPVGR 278 + +A+G V LVGAGPGD LLT++ L+ +Q ADVV YD LVSPE+LD +RRDA RI VG+ Sbjct: 6 QHRALGEVALVGAGPGDAGLLTLRGLQVMQQADVVLYDHLVSPEVLDLVRRDAERICVGK 65 Query: 279 RVGKPGIGQDAINALMIEAAQSGQRAVRLKGGDSFIFGRGGEEIEALRDAGVAYSIIPGV 338 R G + Q+A N L++ AQ G+R VRLKGGD FIFGRGGEE++ + AG+ + ++PGV Sbjct: 66 RAGAHSVTQEATNQLLVTLAQQGKRVVRLKGGDPFIFGRGGEELQVVAQAGIPFQVVPGV 125 Query: 339 SAGLGAAAQFEVPLTFRHEALRITFLTAHKARDAEVVDWSVLTDKKMTVVVYMGMTAAPS 398 +A GA A +PLT R A +TF+T H D + +DW L + T+ +YMG A + Sbjct: 126 TAAAGATAYAGIPLTHRDHAQSVTFITGHCRPDGDDLDWQTLARGRQTLAIYMGTVKAAA 185 Query: 399 IREGMLAAGRSPET 412 I + ++A GRS T Sbjct: 186 ISQQLIAHGRSSTT 199 >PA2611_2 [H] COG0007 Uroporphyrinogen-III methylase Pae Pseudomonas aeruginosa Length = 252 Score = 187 bits (474), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 95/194 (48%), Positives = 125/194 (64%) Query: 222 AIGHVTLVGAGPGDPDLLTVKALRALQDADVVFYDELVSPEILDRIRRDATRIPVGRRVG 281 A G V LVGAGPGDPDLLT +ALR +Q ADVV YD LV+P IL+ RRDA R+ VG+R Sbjct: 2 ATGEVYLVGAGPGDPDLLTFRALRLMQQADVVLYDRLVAPSILELCRRDAERLYVGKRRA 61 Query: 282 KPGIGQDAINALMIEAAQSGQRAVRLKGGDSFIFGRGGEEIEALRDAGVAYSIIPGVSAG 341 + + QD IN L++E A G+R +RLKGGD FIFGRGGEEI+ L G+ + ++PG++A Sbjct: 62 EHAVPQDRINRLLVELASQGKRVLRLKGGDPFIFGRGGEEIDELAAHGIPFQVVPGITAA 121 Query: 342 LGAAAQFEVPLTFRHEALRITFLTAHKARDAEVVDWSVLTDKKMTVVVYMGMTAAPSIRE 401 G AA +PLT R A + F+T H + W L T+V YMG+ P I E Sbjct: 122 SGCAAYAGIPLTHRDHAQSVRFVTGHLKDGTTDLPWQDLVAPGQTLVFYMGLVGLPVICE 181 Query: 402 GMLAAGRSPETXSS 415 ++A GRS +T ++ Sbjct: 182 QLVAHGRSAQTPAA 195 >YPO0158_2 [H] COG0007 Uroporphyrinogen-III methylase Ype Yersinia pestis Length = 267 Score = 182 bits (463), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 87/184 (47%), Positives = 127/184 (69%), Gaps = 1/184 (0%) Query: 224 GHVTLVGAGPGDPDLLTVKALRALQDADVVFYDELVSPEILDRIRRDATRIPVGRRVGKP 283 G V LVGAGPGD LLT+K L+ +Q ADVV YD LVS E+++ +RRDA RI VG++ G Sbjct: 10 GEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDEVMNLVRRDAERIFVGKQSGHH 69 Query: 284 GIGQDAINALMIEAAQSGQRAVRLKGGDSFIFGRGGEEIEALRDAGVAYSIIPGVSAGLG 343 + Q+ IN ++++ AQSG+R VRLKGGD FIFGRGGEE+E L G+ +S++PG++A G Sbjct: 70 CVPQEQINQILLQQAQSGKRVVRLKGGDPFIFGRGGEELEELAGYGIPFSVVPGITAASG 129 Query: 344 AAAQFEVPLTFRHEALRITFLTAHKARDAEVVDWSVLTDKKMTVVVYMGMTAAPSIREGM 403 +A +PLT R A + +T H ++ + +DW+ L +K T+V YMG++ A I++ + Sbjct: 130 CSAYSGIPLTHRDHAQSVRLVTGHAKKEGQ-LDWANLAAEKQTLVFYMGLSQAGEIQQQL 188 Query: 404 LAAG 407 + G Sbjct: 189 IQHG 192 >STM3477_2 [H] COG0007 Uroporphyrinogen-III methylase Sty Salmonella typhimurium LT2 Length = 247 Score = 180 bits (457), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 89/184 (48%), Positives = 124/184 (67%), Gaps = 1/184 (0%) Query: 224 GHVTLVGAGPGDPDLLTVKALRALQDADVVFYDELVSPEILDRIRRDATRIPVGRRVGKP 283 G V LVGAGPGD LLT+K L+ +Q AD+V YD LVS +I++ +RRDA R+ VG+R G Sbjct: 6 GEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYH 65 Query: 284 GIGQDAINALMIEAAQSGQRAVRLKGGDSFIFGRGGEEIEALRDAGVAYSIIPGVSAGLG 343 + Q+ IN +++ AQ G+R VRLKGGD FIFGRGGEE+E L AG+ +S++PG++A G Sbjct: 66 CVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASG 125 Query: 344 AAAQFEVPLTFRHEALRITFLTAHKARDAEVVDWSVLTDKKMTVVVYMGMTAAPSIREGM 403 +A +PLT R A + +T H E +DW L +K T+V YMG+ A +I+E + Sbjct: 126 CSAYSGIPLTHRDYAQSVRLVTGHLKTGGE-LDWENLAAEKQTLVFYMGLNQAATIQEKL 184 Query: 404 LAAG 407 +A G Sbjct: 185 IAFG 188