BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0040.0004.p (259 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value TM1724 [IQR] COG1028 Dehydrogenases with different specificities... 162 6e-40 DR1943 [IQR] COG1028 Dehydrogenases with different specificities... 149 6e-36 VC2021 [IQR] COG1028 Dehydrogenases with different specificities... 146 5e-35 SA2260 [IQR] COG1028 Dehydrogenases with different specificities... 145 9e-35 YPO2539 [IQR] COG1028 Dehydrogenases with different specificitie... 144 1e-34 >TM1724 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Tma Thermotoga maritima Length = 246 Score = 162 bits (410), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 93/250 (37%), Positives = 143/250 (57%), Gaps = 12/250 (4%) Query: 11 VKGLTVLVTGAASGMGRATARVFADEGANVAVTDLTEEGTQAVAKEISASGGSAKAWTLD 70 ++G L+TGAASG+G+AT +FA EGA V D+++E ++ KE G + L+ Sbjct: 3 LEGKVCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVLN 62 Query: 71 VSDRDAITKVVNDVAAHFGGLDIIVNNAGIS-----VRVPIDDPGYEDAWARGIAVMLTA 125 V+DRD I +VV V +G +D++VNNAGI+ VR+ E+ W I V L Sbjct: 63 VTDRDQIKEVVEKVVQKYGRIDVLVNNAGITRDALLVRMK------EEDWDAVINVNLKG 116 Query: 126 HPRIIRAALPYLRKSRSPRIVNIASTEALGATALHSPYSAAKGGVTSLTRSLAVELGREG 185 + + +PY+ K R+ IVN++S + + Y+A+K GV +T++ A EL Sbjct: 117 VFNVTQMVVPYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRN 176 Query: 186 ITVNCICPGPIRTAITDRISEEHKTLYAKRRTALARYGDPEEVAHMTLSLCLPAASFLTG 245 I VN + PG I T +T+++ E+ + A R L R+G PEEVA + L L +S++TG Sbjct: 177 IRVNAVAPGFIETPMTEKLPEKARET-ALSRIPLGRFGKPEEVAQVILFLASDESSYVTG 235 Query: 246 AVIPVDGGLM 255 VI +DGGL+ Sbjct: 236 QVIGIDGGLV 245 >DR1943 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Dra Deinococcus radiodurans Length = 254 Score = 149 bits (376), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 98/244 (40%), Positives = 138/244 (56%), Gaps = 13/244 (5%) Query: 17 LVTGAASGMGRATARVFADEGANVAV-TDLTEEGTQAVAKEISASGGSAKAWTLDVSDRD 75 LVTG++ G+GRA A A +G VAV E Q VA +I A+GG+A+ + D+S Sbjct: 15 LVTGSSRGLGRAMALRLAQDGFTVAVHYGRGEAEAQQVAADIRAAGGAAQVFGADLSQPA 74 Query: 76 AITKVVNDVAAHFGGLDIIVNNAGIS-----VRVPIDDPGYEDAWARGIAVMLTAHPRII 130 +V DV A G LD++VNNAGI+ +R+ +D W + L++ Sbjct: 75 NAGTLVEDVIAALGRLDVLVNNAGITRDGLAIRMKDED------WDAVLQTNLSSAFAAC 128 Query: 131 RAALPYLRKSRSPRIVNIASTEALGATALHSPYSAAKGGVTSLTRSLAVELGREGITVNC 190 RAAL ++ K+RS RIVN++S AL + Y A+K G+ LTR+LA E G GITVN Sbjct: 129 RAALKHMMKNRSGRIVNVSSVVALAGNPGQANYVASKAGLIGLTRALAKEYGGRGITVNA 188 Query: 191 ICPGPIRTAITDRISEEHKTLYAKRRTALARYGDPEEVAHMTLSLCLPAASFLTGAVIPV 250 I PG I + +T ++ E+ K Y + LAR+G PEEVA + L A ++TG I V Sbjct: 189 IAPGFIESDMTAKLPEDTKKQY-QANIPLARFGQPEEVAALVAFLASEGAGYITGQTIGV 247 Query: 251 DGGL 254 DGG+ Sbjct: 248 DGGM 251 >VC2021 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Vch Vibrio cholerae Length = 248 Score = 146 bits (368), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 90/254 (35%), Positives = 143/254 (56%), Gaps = 9/254 (3%) Query: 1 MSEYKQLSRSVKGLTVLVTGAASGMGRATARVFADEGANVAVTDLTEEGTQAVAKEISAS 60 MS++ L +G LVTGA+ G+G+A A + A+ GA V T +E G QA++ + Sbjct: 1 MSQFMNL----EGKVALVTGASRGIGKAIAELLAERGAKVIGTATSESGAQAISDYL--- 53 Query: 61 GGSAKAWTLDVSDRDAITKVVNDVAAHFGGLDIIVNNAGISVRVPIDDPGYEDAWARGIA 120 G + K L+V++ ++I V+ + FGG+DI+VNNAGI+ R + E+ W+ + Sbjct: 54 GDNGKGMALNVTNPESIEAVLKAITDEFGGVDILVNNAGIT-RDNLLMRMKEEEWSDIME 112 Query: 121 VMLTAHPRIIRAALPYLRKSRSPRIVNIASTEALGATALHSPYSAAKGGVTSLTRSLAVE 180 LT+ R+ +A L + K R RI+N+ S A + Y+AAK GV T+S+A E Sbjct: 113 TNLTSIFRLSKAVLRGMMKKRQGRIINVGSVVGTMGNAGQANYAAAKAGVIGFTKSMARE 172 Query: 181 LGREGITVNCICPGPIRTAITDRISEEHKTLYAKRRTALARYGDPEEVAHMTLSLCLPAA 240 + G+TVN + PG I T +T +++E +T + A R GDP E+A L P A Sbjct: 173 VASRGVTVNTVAPGFIETDMTKALNDEQRTATLAQVPA-GRLGDPREIASAVAFLASPEA 231 Query: 241 SFLTGAVIPVDGGL 254 +++TG + V+GG+ Sbjct: 232 AYITGETLHVNGGM 245 >SA2260 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sau Staphylococcus aureus N315 Length = 272 Score = 145 bits (366), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 91/253 (35%), Positives = 140/253 (55%), Gaps = 21/253 (8%) Query: 17 LVTGAASGMGRATARVFADEGANVAVTDLTEEGTQAVAKEISASGGSAKAWTLDVSDRDA 76 +VTGA++G+G+A+A A EGA V D+ E ++ V K I ++G +AKA+ +D+SD Sbjct: 10 VVTGASTGIGQASAIALAQEGAYVLAVDIAEAVSETVDK-IKSNGDNAKAYNVDISDEQQ 68 Query: 77 ITKVVNDVAAHFGGLDIIVNNAGISV------RVPIDDPGYEDAWARGIAVMLTAHPRII 130 + V+D+ FG +D++ NNAG+ PID + + + V + + Sbjct: 69 VVDFVSDIKEQFGRIDVLFNNAGVDNAAGRIHEYPID------VYDKIMNVDMRGTILMT 122 Query: 131 RAALPYLRKSRSPRIVNIASTEALGATALHSPYSAAKGGVTSLTRSLAVELGREGITVNC 190 + LP L ++ IVN +S S Y+AAKG V + T+S+A+E GR+GI N Sbjct: 123 KMMLP-LMMNQGGSIVNTSSFSGQAEDLYRSGYNAAKGAVINFTKSIAIEYGRDGIRSNA 181 Query: 191 ICPGPIRTAITDRI---SEEH--KTLYAKRR--TALARYGDPEEVAHMTLSLCLPAASFL 243 I PG I T + D++ SE+ KT ++ T L R G PEEVA + + L +SF+ Sbjct: 182 IAPGTIETPLVDKLTGTSEDDAGKTFRENQKWMTPLGRLGKPEEVAKLVVFLASDDSSFI 241 Query: 244 TGAVIPVDGGLMA 256 TG I +DGG+MA Sbjct: 242 TGETIRIDGGVMA 254 >YPO2539 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Ype Yersinia pestis Length = 254 Score = 144 bits (364), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 85/248 (34%), Positives = 141/248 (56%), Gaps = 4/248 (1%) Query: 10 SVKGLTVLVTGAASGMGRATARVFADEGANVAVTDLTEEGTQAVAKEISASGGSAKAWTL 69 S++ VL+TG+A G+G A+ A+ GA + + D+T E + E+ ASG A A Sbjct: 6 SLENRKVLITGSAQGIGFLLAKGLAEFGAEIIINDITAERAEKAVAELRASGFIAHAAAF 65 Query: 70 DVSDRDAITKVVNDVAAHFGGLDIIVNNAGISVRVPIDDPGYEDAWARGIAVMLTAHPRI 129 +V++ D + + + + +H G +D+++NNAGI R + +D W IAV + + Sbjct: 66 NVTNHDEVNEAIEKIESHIGAIDVLINNAGIQRRHAFTEFPEKD-WDDVIAVNQKSVFLV 124 Query: 130 IRAALPYLRKSRSPRIVNIASTEA-LGATALHSPYSAAKGGVTSLTRSLAVELGREGITV 188 +A Y+ K + +I+NI S ++ LG + +PY+A+KG V LTR + VEL R I V Sbjct: 125 SQAVARYMVKRQRGKIINICSMQSELGRDTI-TPYAASKGAVKMLTRGMCVELARYNIQV 183 Query: 189 NCICPGPIRTAITDRISEEHK-TLYAKRRTALARYGDPEEVAHMTLSLCLPAASFLTGAV 247 N I PG +T +T + ++ T + +RT AR+GDPEE+ + L A+ F+ G + Sbjct: 184 NGIAPGYFKTDMTKALVDDQAFTDWLCKRTPAARWGDPEELIGAAVYLSSKASDFVNGHL 243 Query: 248 IPVDGGLM 255 + VDGG++ Sbjct: 244 LFVDGGML 251