BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0039.0005.p (412 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEI1292 [GEPR] COG0477 Permeases of the major facilitator super... 83 1e-15 BS_yfnC [GEPR] COG0477 Permeases of the major facilitator superf... 82 2e-15 fsr [GEPR] COG0477 Permeases of the major facilitator superfamil... 75 4e-13 Zfsr [GEPR] COG0477 Permeases of the major facilitator superfami... 75 4e-13 ECs0532 [GEPR] COG0477 Permeases of the major facilitator superf... 75 4e-13 >BMEI1292 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 403 Score = 82.8 bits (203), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 112/412 (27%), Positives = 188/412 (45%), Gaps = 41/412 (9%) Query: 8 PQQAKADSALRTLT-GISVAHWVSHFHIFVLPMLFPFLKQQLGVGYVELGLALTVFAVVS 66 P + AD+ + T+ S+ H+++ +LP ++P LK+ + + ++GL F + + Sbjct: 9 PSNSSADNTVLTIILATSLGHFLNDMMQSLLPAIYPMLKENYSLSFWQIGLLTFTFQMTA 68 Query: 67 GLTQAPIGYLADHIGARKILLIGLTVG-GCALIGLGLHLS---YTSLIVCAVLLGLANSV 122 + Q +G D RK + LT G GC LIGL + Y+ L++ A +G +SV Sbjct: 69 SILQPLVGIYTD----RKPMPYSLTFGMGCTLIGLVFLATAHHYSFLLLGAACVGFGSSV 124 Query: 123 YHPADYAILSAHMDEARMGRAFSIHTFAGFLGGAVAPAIMAALVASIGGLGA--LIVAGA 180 +HP + A ++ R G A S+ G G ++ P + A +V G + VA Sbjct: 125 FHP-EAARVARLASGGRHGFAQSLFQVGGNFGSSIGPLLAAFIVLPFGQISVSWFSVAAL 183 Query: 181 VGPLVALFLIVLGIPDAGANKNKSKDDTASK-------ASVITPALMVLTAFFTLLSLST 233 +G V ++ AN NK K D ASV AL+V T + + SL++ Sbjct: 184 IGMFVLWYVGNWYNRYRLANANKPKPDKTLPLPRNRVIASVAVLALLVFTKYIYMASLTS 243 Query: 234 SGINNFGVVALMGGYGASFSTANIALTAFLGASAAGVLAGGYLADWTHRHSQVAAACFAV 293 + + +G S T+ + L FLGA AAG + GG + D + A+ V Sbjct: 244 -----YYTFYTISHFGVSVQTSQLLLFLFLGAVAAGTIIGGPIGDKIGARKVIWASILGV 298 Query: 294 NAALVLLIALLNLPPVA-LTLAMG--LAGFLGGVIAPSRDMMVRNAAPPGAAGRAFGIVS 350 L + NL A LT+ +G LA +I +++++ PG G G+ Sbjct: 299 -LPFTLALPYANLEMTAVLTIIIGLILASAFPAIIVFAQELL------PGRVGMLSGLF- 350 Query: 351 TGFNFG--GIVSPLLFGWIMDQHMPHWVFG--ASVVFM-VLTVLLALVTERK 397 GF FG GI + +L G + DQ +V+ + + F+ +LT+ L + R+ Sbjct: 351 FGFAFGMAGIAAAVL-GIVADQKGIEFVYRICSYLPFLGLLTIFLPKLERRR 401 >BS_yfnC [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 409 Score = 82.0 bits (201), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/289 (26%), Positives = 131/289 (45%), Gaps = 19/289 (6%) Query: 5 LAAPQQAKA-----DSALRTLTGISVAHWVSHFHIFVLPMLFPFLKQQLGVGYVELGLAL 59 +AAP + K + L I + H ++ V+P +FP L++ + + + +LG+ Sbjct: 3 IAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMFPILERSMSLTFTQLGIIA 62 Query: 60 TVFAVVSGLTQAPIGYLADHIGARKILLIGLTVGGCALIGLGLHLSYTSLIVCAVLLGLA 119 +VS + Q +G+ D L +GLT ++GL S+ +++ C +GL Sbjct: 63 FTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILGLAFAPSFITILCCVFFIGLG 122 Query: 120 NSVYHPADYAILSAHMDE-ARMGRAFSIHTFAGFLGGAVAPAIMAALVASIGGLGALIVA 178 ++++HP + A+M + G A SI+ G G A+AP I A ++ +G GA+ Sbjct: 123 SAIFHPEGSRV--AYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFT 180 Query: 179 GAVGPLVALFLIVL---------GIPDAGANKNKSKDDTASKASVITPALMVLTAFFTLL 229 V L +FL+ + + + K+ ++TA SV++ AL+++ Sbjct: 181 -LVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENTAITKSVVS-ALIIIIFLIFAR 238 Query: 230 SLSTSGINNFGVVALMGGYGASFSTANIALTAFLGASAAGVLAGGYLAD 278 S TS I NF M Y S A + FL A G GG LAD Sbjct: 239 SWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAIGTFLGGPLAD 287 >fsr [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 406 Score = 74.7 bits (182), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 132/293 (45%), Gaps = 27/293 (9%) Query: 6 AAPQQAKADSALRTLTGISVAHWVSHFHIFVLPMLFPFLKQQLGVGYVELGLALTVFAVV 65 AA KA ++ L IS++H ++ ++ ++P L+ + + ++++G+ F + Sbjct: 13 AAASTTKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQSEFSLTFMQIGMITLTFQLA 72 Query: 66 SGLTQAPIGYLADHIGARKILLIGLTVGGCALIGLGLHLSYTSLIVCAVLLGLANSVYHP 125 S L Q +GY D L IG+ L+ L L S+ ++++ A L+G +SV+HP Sbjct: 73 SSLLQPVVGYWTDKYPMPWSLPIGMCFTLSGLVLLALAGSFGAVLLAAALVGTGSSVFHP 132 Query: 126 ADYAILSAHMDE-ARMGRAFSIHTFAGFLGGAVAPAIMAALVASIG-GLGALIVAGAVGP 183 + A M R G A SI G G ++ P + A ++A G G A V A+ Sbjct: 133 ESSRV--ARMASGGRHGLAQSIFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAAL-- 188 Query: 184 LVALFLIVLGIPDAGANKNKSKDDTASKASVITP-------------ALMVLTAFFTLLS 230 L ++VL + + KA++I P +++ + +F + S Sbjct: 189 ---LAIVVLAQISRWYSAQHRMNKGKPKATIINPLPRNKVVLAVSILLILIFSKYFYMAS 245 Query: 231 LSTSGINNFGVVALMGGYGASFSTANIALTAFLGASAAGVLAGGYLADWTHRH 283 +S+ + LM +G S A + L AFL A AAG + GG + D R Sbjct: 246 ISS-----YYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRK 293 >Zfsr [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 406 Score = 74.7 bits (182), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 132/293 (45%), Gaps = 27/293 (9%) Query: 6 AAPQQAKADSALRTLTGISVAHWVSHFHIFVLPMLFPFLKQQLGVGYVELGLALTVFAVV 65 AA KA ++ L IS++H ++ ++ ++P L+ + + ++++G+ F + Sbjct: 13 AAASTTKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQSEFSLTFMQIGMITLTFQLA 72 Query: 66 SGLTQAPIGYLADHIGARKILLIGLTVGGCALIGLGLHLSYTSLIVCAVLLGLANSVYHP 125 S L Q +GY D L IG+ L+ L L S+ ++++ A L+G +SV+HP Sbjct: 73 SSLLQPVVGYWTDKYPMPWSLPIGMCFTLSGLVLLALAGSFGAVLLAAALVGTGSSVFHP 132 Query: 126 ADYAILSAHMDE-ARMGRAFSIHTFAGFLGGAVAPAIMAALVASIG-GLGALIVAGAVGP 183 + A M R G A SI G G ++ P + A ++A G G A V A+ Sbjct: 133 ESSRV--ARMASGGRHGLAQSIFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAAL-- 188 Query: 184 LVALFLIVLGIPDAGANKNKSKDDTASKASVITP-------------ALMVLTAFFTLLS 230 L ++VL + + KA++I P +++ + +F + S Sbjct: 189 ---LAIVVLAQISRWYSAQHRMNKGKPKATIINPLPRNKVVLAVSILLILIFSKYFYMAS 245 Query: 231 LSTSGINNFGVVALMGGYGASFSTANIALTAFLGASAAGVLAGGYLADWTHRH 283 +S+ + LM +G S A + L AFL A AAG + GG + D R Sbjct: 246 ISS-----YYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRK 293 >ECs0532 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 406 Score = 74.7 bits (182), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 132/293 (45%), Gaps = 27/293 (9%) Query: 6 AAPQQAKADSALRTLTGISVAHWVSHFHIFVLPMLFPFLKQQLGVGYVELGLALTVFAVV 65 AA KA ++ L IS++H ++ ++ ++P L+ + + ++++G+ F + Sbjct: 13 AAASTTKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQSEFSLTFMQIGMITLTFQLA 72 Query: 66 SGLTQAPIGYLADHIGARKILLIGLTVGGCALIGLGLHLSYTSLIVCAVLLGLANSVYHP 125 S L Q +GY D L IG+ L+ L L S+ ++++ A L+G +SV+HP Sbjct: 73 SSLLQPVVGYWTDKYPMPWSLPIGMCFTLSGLVLLALAGSFGAVLLAAALVGTGSSVFHP 132 Query: 126 ADYAILSAHMDE-ARMGRAFSIHTFAGFLGGAVAPAIMAALVASIG-GLGALIVAGAVGP 183 + A M R G A SI G G ++ P + A ++A G G A V A+ Sbjct: 133 ESSRV--ARMASGGRHGLAQSIFQVGGNFGSSLGPLLAAVIIAPYGKGNVAWFVLAAL-- 188 Query: 184 LVALFLIVLGIPDAGANKNKSKDDTASKASVITP-------------ALMVLTAFFTLLS 230 L ++VL + + KA++I P +++ + +F + S Sbjct: 189 ---LAIVVLAQISRWYSAQHRMNKGKPKATIINPLPRNKVVLAVSILLILIFSKYFYMAS 245 Query: 231 LSTSGINNFGVVALMGGYGASFSTANIALTAFLGASAAGVLAGGYLADWTHRH 283 +S+ + LM +G S A + L AFL A AAG + GG + D R Sbjct: 246 ISS-----YYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRK 293