BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0038.0020.p (1311 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SPAC16C9.06c [L] COG1112 Superfamily I DNA and RNA helicases and... 105 5e-22 YMR080c [L] COG1112 Superfamily I DNA and RNA helicases and heli... 104 2e-21 TM0005 [L] COG1112 Superfamily I DNA and RNA helicases and helic... 102 7e-21 AF1388 [L] COG1112 Superfamily I DNA and RNA helicases and helic... 100 4e-20 YLR430w [L] COG1112 Superfamily I DNA and RNA helicases and heli... 97 4e-19 >SPAC16C9.06c [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Spo Schizosaccharomyces pombe Length = 925 Score = 105 bits (263), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 89/302 (29%), Positives = 150/302 (49%), Gaps = 42/302 (13%) Query: 952 QIVVGTCVGLGRTSLGLTSTAFDLVVVDEAARCTASELLVPL-QAARWVVLVGDHAQLEP 1010 ++ TCVG G + + F V++DEA + + E ++PL A+ VVLVGDH QL P Sbjct: 539 HVICCTCVGAGDRRI--SKYKFRSVLIDEATQASEPECMIPLVLGAKQVVLVGDHQQLGP 596 Query: 1011 QHKPEVINQVAERTGIAKREIQRSDFERVFSTAYGRHSGARLKTQYRMWPPIGQLVSETF 1070 V +A + +S FER+ +S RL QYRM P + + S TF Sbjct: 597 ---------VVMNKKVALASLSQSLFERLIILG---NSPFRLVVQYRMHPCLSEFPSNTF 644 Query: 1071 YPDLALEPGRTEPEIDPLLLPAGLDKPLIWVETDALGEAAFDRRE--EEGSSRINRVEAD 1128 Y + L+ G T E + +D P I ++ + A F + E G+S +NR EA Sbjct: 645 Y-EGTLQNGVTTSE----RIARHVDFPWIQPDSPLMFYANFGQEELSASGTSFLNRTEAS 699 Query: 1129 AIMSLLEDWHGHEPFREWLVTQQKHLAGIGVICMYAAQRDLIRRKLRQS-PLAYLLDQHI 1187 ++ + R ++ +Q IG++ Y QR I + ++ + + L + + Sbjct: 700 TCEKIVTTF-----LRSNVLPEQ-----IGIVTPYDGQRSYIVQYMQNNGSMQKDLYKAV 749 Query: 1188 KVGTVDSYQGKENPIIVLSLVRNNDGGRQEGGVKCIQEGFLSAPNRVNVAASRAMDRLVI 1247 +V +VD++QG+E I+LS VR+++ G+ GF++ P R+NVA +RA +++ Sbjct: 750 EVASVDAFQGREKDFIILSCVRSSE----HQGI-----GFVNDPRRLNVALTRAKYGVIV 800 Query: 1248 VG 1249 +G Sbjct: 801 LG 802 >YMR080c [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Sce Saccharomyces cerevisiae Length = 971 Score = 104 bits (259), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 105/335 (31%), Positives = 159/335 (47%), Gaps = 56/335 (16%) Query: 938 RIQRSFESFLAGTRQIVVGTCVGLGRTSLGLTSTAFDLVVVDEAARCTASELLVPL-QAA 996 ++ R E+ + +V TCVG G L T F V++DE+ + + E L+P+ + A Sbjct: 534 KLVRKTEAEILNKADVVCCTCVGAGDKRL---DTKFRTVLIDESTQASEPECLIPIVKGA 590 Query: 997 RWVVLVGDHAQLEPQHKPEVINQVAERTGIAKREIQRSDFERVFSTAYGRHSGARLKTQY 1056 + V+LVGDH QL P + ER A +++S FER+ S H RL+ QY Sbjct: 591 KQVILVGDHQQLGPV--------ILERKA-ADAGLKQSLFERLISLG---HVPIRLEVQY 638 Query: 1057 RMWPPIGQLVSETFYPDLALEPG-----RTEPEIDPLLLPAGLDKPLIWVETDALGEAAF 1111 RM P + + S FY + +L+ G RT P P + W A + Sbjct: 639 RMNPYLSEFPSNMFY-EGSLQNGVTIEQRTVPN-SKFPWPIRGIPMMFW--------ANY 688 Query: 1112 DRRE--EEGSSRINRVEADAIMSLLEDWHGHEPFREWLVTQQKHLAGIGVICMYAAQRDL 1169 R E G+S +NR+EA ++ + FR+ + +Q IGVI Y QR Sbjct: 689 GREEISANGTSFLNRIEAMNCERIIT-----KLFRDGVKPEQ-----IGVITPYEGQRAY 738 Query: 1170 IRRKLRQS-PLAYLLDQHIKVGTVDSYQGKENPIIVLSLVRNNDGGRQEGGVKCIQEGFL 1228 I + ++ + L L ++V +VD++QG+E I+LS VR N+ Q+ GFL Sbjct: 739 ILQYMQMNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANE---QQAI------GFL 789 Query: 1229 SAPNRVNVAASRAMDRLVIVG---ARMRWTSWKPL 1260 P R+NV +RA LVI+G + R T W L Sbjct: 790 RDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHL 824 >TM0005 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Tma Thermotoga maritima Length = 650 Score = 102 bits (254), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 85/297 (28%), Positives = 140/297 (47%), Gaps = 60/297 (20%) Query: 968 LTSTAFDLVVVDEAARCTASELLVPLQAARWVVLVGDHAQLEPQHKPEVINQVAERTGIA 1027 L+ FD+VVVDEA++ T +L+P+ + VL GDH QL P ++++ A Sbjct: 372 LSGIVFDVVVVDEASQATIPSILIPISKGKKFVLAGDHKQLPPT----ILSEDA------ 421 Query: 1028 KREIQRSDFERVFSTAYGRHSGARLKTQYRMWPPIGQLVSETFYP--------------- 1072 +++ R+ FE + T Y S L TQYRM + + SE FY Sbjct: 422 -KDLSRTLFEELI-TRYPEKSSL-LDTQYRMNELLMEFPSEEFYDGKLKAAEKVRNITLF 478 Query: 1073 DLALEPGRTEPEIDPLLLPAGLDKPLIWVETDALGEAAFDRREEEGSSRINRVEADAIMS 1132 DL +E D +L P + L++++T + F+R+ ++ SR N +EA + Sbjct: 479 DLGVEIPNFGKFWDVVLSPKNV---LVFIDTKNRSD-RFERQRKDSPSRENPLEAQIVKE 534 Query: 1133 LLEDWHGHEPFREWLVTQQKHLAGIGVICMYAAQRDLIRRKLRQSPLAYLLDQHIKVGTV 1192 ++E +W IG+I Y Q +LIR L++ ++V +V Sbjct: 535 VVEKLLSMGVKEDW----------IGIITPYDDQVNLIRE---------LIEAKVEVHSV 575 Query: 1193 DSYQGKENPIIVLSLVRNNDGGRQEGGVKCIQEGFLSAPNRVNVAASRAMDRLVIVG 1249 D +QG+E +I++S VR+N G + GFL R+NV+ +RA +L+ G Sbjct: 576 DGFQGREKEVIIISFVRSNKNG---------EIGFLEDLRRLNVSLTRAKRKLIATG 623 >AF1388 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Afu Archaeoglobus fulgidus Length = 648 Score = 99.8 bits (247), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 134/542 (24%), Positives = 234/542 (43%), Gaps = 135/542 (24%) Query: 723 LLQGPPGTGKTRFIAALTHYAITKGLARNVLVASQSHEAVNTAAEAVLTLFRKTGGLPSL 782 L+ GP GTGKTR + + + +G VLV ++S+ AV+ E L S Sbjct: 188 LIHGPFGTGKTRTVVEVVRQLVKRG--ERVLVTAESNTAVDNLVE-----------LLSD 234 Query: 783 LRVAMDEDVVSPPLRPFHTAKVEQSLKDRFRASFRERLAVAGEALGLPDSAIDDIVLLES 842 +++ +R H ++VE+ LK+ AS L PD Sbjct: 235 MKI----------VRLGHPSRVEKRLKEHTLASL---------VLNHPDY---------- 265 Query: 843 GIRPIAARMIELLHSEERDEQRINGLAETVNLHLERLKLN--ELSASIDEQDWLTLA--E 898 +R E+ I G E + +ERL +L + +++ L LA Sbjct: 266 ----------------KRIEE-IKGKIEEIERRMERLTKPSPQLRRGLSDEEILRLARSN 308 Query: 899 RAAQRLMARHARTDGINAERADRLCSAAAVGRDFVGTVSRIQRSFESFLAGTRQIVVGTC 958 R A+ + A+ R+ A+ + + A+ + + +R + + + +V+ T Sbjct: 309 RGARGVAAKKIRS------MAEWIEARKALDQLYTEMKEEEERIVKEIIEES-DVVIST- 360 Query: 959 VGLGRTSLGLTSTAFDLVVVDEAARCTASELLVPLQAARWVVLVGDHAQLEPQHKPEVIN 1018 +S L +FD V+DEA++ T +L+P+ AR +L GDH QL P Sbjct: 361 ----NSSAFLLEESFDTAVIDEASQATIPSVLIPINRARKFILAGDHRQLPP-------- 408 Query: 1019 QVAERTGIAKREIQRSDFERVFSTAYGRHSGARLKTQYRMWPPIGQLVSETFY------- 1071 T + ++ + FE++ Y S L QYRM + + S FY Sbjct: 409 -----TVMKAEKLSETLFEKLIEL-YPEKSQL-LNVQYRMNEKLMEFPSREFYGGRIVAH 461 Query: 1072 ---PDLAL-EPGRTEPEIDPLLLPAGLDKPLIWVETDALGEAAFDRREEEGSSRINRVEA 1127 +AL + + E E +L D+PL++++T + ++ + + +SR NR+EA Sbjct: 462 ESCTAIALSQIAKREAEKLREILG---DEPLVFIDTSKC-KNRWEGKLADSTSRYNRLEA 517 Query: 1128 DAIMSLLEDWHGHEPFREWLVTQQKHLAGIGVICMYAAQRDLIRRKLRQSPLAYLLDQHI 1187 + + ++ E + L +Q IGVI Y Q DL+R K+ + Sbjct: 518 EIVTEIV-----TELLKMGLKKEQ-----IGVITPYDDQVDLLREKV-----------DV 556 Query: 1188 KVGTVDSYQGKENPIIVLSLVRNNDGGRQEGGVKCIQEGFLSAPNRVNVAASRAMDRLVI 1247 +V +VD +QG+E +I++S VR+N + + GFL R+NV+ +RA +L++ Sbjct: 557 EVSSVDGFQGREKEVIIISFVRSN---------RKREIGFLDDLRRLNVSLTRARRKLIM 607 Query: 1248 VG 1249 VG Sbjct: 608 VG 609 >YLR430w [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits Sce Saccharomyces cerevisiae Length = 2231 Score = 96.7 bits (239), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 137/569 (24%), Positives = 234/569 (41%), Gaps = 81/569 (14%) Query: 696 EQALAGYELNADQKLAFDRIIKSRPVGLLQGPPGTGKTRFIAALTHYAITKGLARNVLVA 755 E Y+LN Q A + L+QGPPGTGKT+ I + Y ++ A + V Sbjct: 1327 ETVKKSYKLNTSQAEAIVNSVSKEGFSLIQGPPGTGKTKTILGIIGYFLSTKNASSSNVI 1386 Query: 756 SQSHEAVNTAAEAVLTLFRKTGGLPSLLRVAMDEDVVSPPLRPFHTAKVEQSLKDRFRAS 815 E ++ E +L + PS A+DE + +++ + D+ Sbjct: 1387 KVPLEKNSSNTEQLLKKQKILICAPS--NAAVDEICL----------RLKSGVYDKQGHQ 1434 Query: 816 FRERLAVAGEALGLPDSAIDDIVLLESGIRPIAARMIELLHSEERDEQRINGLAETVNLH 875 F+ +L G + + + AI D+ L E + I R E+ E + + N + + L Sbjct: 1435 FKPQLVRVGRS-DVVNVAIKDLTLEELVDKRIGERNYEIRTDPELERKFNNAVTKRREL- 1492 Query: 876 LERLKLN------ELSASIDEQDWLTLAERAAQRLMARHARTDGINAERADRLCSAAAVG 929 R KL+ E S ++ L L R +++ R E+ S Sbjct: 1493 --RGKLDSESGNPESPMSTEDISKLQLKIRELSKIINELGRDRDEMREKN----SVNYRN 1546 Query: 930 RDFVGTVSRIQRSFESFLAGTRQIVVGTCVGLGRTSLGLTSTAFDLVVVDEAARCTASEL 989 RD +R+ ++ + I+ T G L FD V++DEA +CT Sbjct: 1547 RDLD------RRNAQAHILAVSDIICSTLSGSAHDVLATMGIKFDTVIIDEACQCTELSS 1600 Query: 990 LVPLQ-AARWVVLVGDHAQLEPQHKPEVINQVAERTGIAKREIQRSDFERVFSTAYGRHS 1048 ++PL+ + ++VGD QL P V++ A + + +S F R+ + S Sbjct: 1601 IIPLRYGGKRCIMVGDPNQLPPT----VLSGAA-----SNFKYNQSLFVRMEKNS----S 1647 Query: 1049 GARLKTQYRMWPPIGQLVSETFYPDLALEPGRTE--PEIDPLLLPAGLDKPLIWVETDAL 1106 L QYRM P I + S FY GR + P +D L +P W + + L Sbjct: 1648 PYLLDVQYRMHPSISKFPSSEFYQ------GRLKDGPGMDILN-----KRP--WHQLEPL 1694 Query: 1107 GEAAF----DRREEEGSSRINRVEADAIMSLLE--DWHGHEPFREWLVTQQKHLAGIGVI 1160 F R+E+ + ++ + I +E D+ FR++ + IG+I Sbjct: 1695 APYKFFDIISGRQEQNAKTMSYTNMEEIRVAIELVDYL----FRKF-DNKIDFTGKIGII 1749 Query: 1161 CMYAAQRDLIRRKLRQSPLAYLLDQHIKVGTVDSYQGKENPIIVLSLVRNNDGGRQEGGV 1220 Y Q +R++ + ++++ I T+D +QG+E II++S VR +D Sbjct: 1750 SPYREQMQKMRKEFARY-FGGMINKSIDFNTIDGFQGQEKEIILISCVRADDTKS----- 1803 Query: 1221 KCIQEGFLSAPNRVNVAASRAMDRLVIVG 1249 GFL R+NVA +RA + ++G Sbjct: 1804 ---SVGFLKDFRRMNVALTRAKTSIWVLG 1829