BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0247.p (469 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ydjE [GEPR] COG0477 Permeases of the major facilitator superfami... 276 7e-74 ZydjE [GEPR] COG0477 Permeases of the major facilitator superfam... 246 6e-65 ECs2476 [GEPR] COG0477 Permeases of the major facilitator superf... 246 6e-65 ydjK [GEPR] COG0477 Permeases of the major facilitator superfami... 220 5e-57 Z2813 [GEPR] COG0477 Permeases of the major facilitator superfam... 219 7e-57 >ydjE [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 452 Score = 276 bits (706), Expect = 7e-74, Method: Compositional matrix adjust. Identities = 170/444 (38%), Positives = 239/444 (53%), Gaps = 6/444 (1%) Query: 12 GARLDRLPICGFHWRILALIGAGMFLDAFDIYLAGGVLGAVLKEGWSTLELNAAFVSATF 71 GARLDRLP+ FH+RI +I + L F Y VL ++ GWS LNAAF SA Sbjct: 8 GARLDRLPLARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALM 67 Query: 72 VGMTIGAWCSGILGDRFGRRFSYQMNLAIFGLASIAAAFAPNMIVLIGLRFIIGIGLGAE 131 G IG+ G +GD FGRR ++++NL I G+A+ AAF P+M LI RF++G G+GA Sbjct: 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGAL 127 Query: 132 IVVGYATLTEFVPASSRGRWIGLLAVITNFSLFVSSMVGLWVIPTLGWRYMFGLVGCLAM 191 I+VGYA+ TEF+PA+ RG+W L+ + N+S +S+ +G+ VI WR MF L G + Sbjct: 128 IMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGIL 187 Query: 192 VVWFLR-KSMPESPRWLAANGRADEAEKILSAIEAEAARKAV-----LPAVAARAPAQES 245 + WFL K ESPRWLA G+ AE L +E + R+ L + + + + Sbjct: 188 LAWFLSGKYFIESPRWLAGKGQIAGAECQLREVEQQIEREKSIRLPPLTSYQSNSKVKVI 247 Query: 246 PGAVWRLFQPPYLARTLLGSLLHIVVGFSLYGFIGWLPTFMVKGGHSVVSSLGYTTVMAL 305 G W LF+ L RTL+ + I + SLY W+PT V G V S+ T V+ + Sbjct: 248 KGTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMI 307 Query: 306 GGPVGSVVGLVLADRLGRRLSIVCSSIAAAVLGIAYPYMPDGVALAAVGFLLITAIYVML 365 G PVG + ++ D RRL I AVLG Y A+ G ++I +Y+ + Sbjct: 308 GAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYV 367 Query: 366 ATGFAMHVPELFPTRYRLRGTAICATSGRIATALVQYVVVAIFAWQGLTGVLTTLAGILV 425 A+++PEL+PT RLRG+ GRI Y V A+ G V L +L+ Sbjct: 368 CFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLL 427 Query: 426 FQAVVFLVFGFETKGRSLEDASAV 449 A+V +FG ET+ SLE+ S V Sbjct: 428 LCALVLSIFGIETRKVSLEEISEV 451 >ZydjE [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 416 Score = 246 bits (629), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 155/413 (37%), Positives = 220/413 (53%), Gaps = 6/413 (1%) Query: 43 YLAGGVLGAVLKEGWSTLELNAAFVSATFVGMTIGAWCSGILGDRFGRRFSYQMNLAIFG 102 Y VL ++ GWS LNAAF SA G IG+ G +GD FGRR ++++NL I G Sbjct: 3 YSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVG 62 Query: 103 LASIAAAFAPNMIVLIGLRFIIGIGLGAEIVVGYATLTEFVPASSRGRWIGLLAVITNFS 162 +A+ AAF P+M LI RF++G G+GA I+VGYA+ TEF+PA+ RG+W L+ + N+S Sbjct: 63 IAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWS 122 Query: 163 LFVSSMVGLWVIPTLGWRYMFGLVGCLAMVVWFLR-KSMPESPRWLAANGRADEAEKILS 221 +S+ +G+ VI WR MF L G ++ WFL K ESPRWLA G+ AE L Sbjct: 123 PMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESPRWLAGKGQIAGAECQLR 182 Query: 222 AIEAEAARKAV-----LPAVAARAPAQESPGAVWRLFQPPYLARTLLGSLLHIVVGFSLY 276 +E + R+ L + + + + G W LF+ L RTL+ + I + SLY Sbjct: 183 EVEQQIEREKSIRLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLY 242 Query: 277 GFIGWLPTFMVKGGHSVVSSLGYTTVMALGGPVGSVVGLVLADRLGRRLSIVCSSIAAAV 336 W+PT V G V S+ T V+ +G PVG + ++ D RRL I AV Sbjct: 243 TITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAV 302 Query: 337 LGIAYPYMPDGVALAAVGFLLITAIYVMLATGFAMHVPELFPTRYRLRGTAICATSGRIA 396 LG Y A+ G ++I +Y+ + A+++PEL+PT RLRG+ GRI Sbjct: 303 LGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIV 362 Query: 397 TALVQYVVVAIFAWQGLTGVLTTLAGILVFQAVVFLVFGFETKGRSLEDASAV 449 Y V A+ G V L +L+ A+V +FG ET+ SLE+ S V Sbjct: 363 AVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIETRKVSLEEISEV 415 >ECs2476 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 416 Score = 246 bits (629), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 155/413 (37%), Positives = 220/413 (53%), Gaps = 6/413 (1%) Query: 43 YLAGGVLGAVLKEGWSTLELNAAFVSATFVGMTIGAWCSGILGDRFGRRFSYQMNLAIFG 102 Y VL ++ GWS LNAAF SA G IG+ G +GD FGRR ++++NL I G Sbjct: 3 YSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVG 62 Query: 103 LASIAAAFAPNMIVLIGLRFIIGIGLGAEIVVGYATLTEFVPASSRGRWIGLLAVITNFS 162 +A+ AAF P+M LI RF++G G+GA I+VGYA+ TEF+PA+ RG+W L+ + N+S Sbjct: 63 IAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWS 122 Query: 163 LFVSSMVGLWVIPTLGWRYMFGLVGCLAMVVWFLR-KSMPESPRWLAANGRADEAEKILS 221 +S+ +G+ VI WR MF L G ++ WFL K ESPRWLA G+ AE L Sbjct: 123 PMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESPRWLAGKGQIAGAECQLR 182 Query: 222 AIEAEAARKAV-----LPAVAARAPAQESPGAVWRLFQPPYLARTLLGSLLHIVVGFSLY 276 +E + R+ L + + + + G W LF+ L RTL+ + I + SLY Sbjct: 183 EVEQQIEREKSIRLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLY 242 Query: 277 GFIGWLPTFMVKGGHSVVSSLGYTTVMALGGPVGSVVGLVLADRLGRRLSIVCSSIAAAV 336 W+PT V G V S+ T V+ +G PVG + ++ D RRL I AV Sbjct: 243 TITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAV 302 Query: 337 LGIAYPYMPDGVALAAVGFLLITAIYVMLATGFAMHVPELFPTRYRLRGTAICATSGRIA 396 LG Y A+ G ++I +Y+ + A+++PEL+PT RLRG+ GRI Sbjct: 303 LGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIV 362 Query: 397 TALVQYVVVAIFAWQGLTGVLTTLAGILVFQAVVFLVFGFETKGRSLEDASAV 449 Y V A+ G V L +L+ A+V +FG ET+ SLE+ S V Sbjct: 363 AVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIETRKVSLEEISEV 415 >ydjK [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 459 Score = 220 bits (561), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 155/456 (33%), Positives = 242/456 (53%), Gaps = 19/456 (4%) Query: 10 NAGARLDRLPICGFHWRILALIGAGMFLDAFDIYLAGGVLGAVLKE-GWSTLELNAAFVS 68 + GARLDRLP C +H + A++ G+ + + GG++ A LK GW+ A F + Sbjct: 8 HCGARLDRLPDCRWHSSMFAIVAFGLLVCWSNA--VGGLILAQLKALGWTDNSTTATFSA 65 Query: 69 ATFVGMTIGAWCSGILGDRFGRRFSYQMNLAIFGLASIAAAFAPNMIVLIGLRFIIGIGL 128 T GM +GA GI+GD+ GRR ++ + AI + + AF+PNM LI RF++G+GL Sbjct: 66 ITTAGMFLGALVGGIIGDKTGRRNAFILYEAIHIASMVVGAFSPNMDFLIACRFVMGVGL 125 Query: 129 GAEIVVGYATLTEFVPASSRGRWIGLLAVITNFSLFVSSMVGLWVIPTL----GWRYMFG 184 GA +V +A TE++P +RG W ++ I N+S + S++ + + P + WR Sbjct: 126 GALLVTLFAGFTEYMPGRNRGTWSSRVSFIGNWSYPLCSLIAMGLTPLISAEWNWRVQLL 185 Query: 185 LVGCLAMVVWFLR-KSMPESPRWLAANGRADEAEKILSAIEAEAAR---KAVLPAVAA-- 238 + L+++ L + PESPRWL + GR EAEK++ +IE R K + P V A Sbjct: 186 IPAILSLIATALAWRYFPESPRWLESRGRYQEAEKVMRSIEEGVIRQTGKPLPPVVIADD 245 Query: 239 -RAPAQESPGAVWRLFQPPYLARTLLGSLLHIVVGFSLYGFIGWLPTFMVKGGHSVVSSL 297 +AP Q P + L L R +LGS + I + Y I WLPT + G ++ S+ Sbjct: 246 GKAP-QAVPYSA--LLTGVLLKRVILGSCVLIAMNVVQYTLINWLPTIFMTQGINLKDSI 302 Query: 298 GYTTVMALGGPVGSVVGLVLADRLGRRLSIVCSSIAAAVLGIAYPYMPDGVALAAVGFLL 357 T+ G P G + +++ D++ R+ V I AVLG Y + + +GF L Sbjct: 303 VLNTMSMFGAPFGIFIAMLVMDKIPRKTMGVGLLILIAVLGYIYSLQTSMLLITLIGFFL 362 Query: 358 ITAIYVMLATGFAMHVPELFPTRYRLRGTAICATSGRIATALVQYVVVAIFAWQGLTGVL 417 IT +Y+ + A++VPE++PT +LRG+ + GRI+ Y V + + G+TGV Sbjct: 363 ITFVYMYVCYASAVYVPEIWPTEAKLRGSGLANAVGRISGIAAPYAVAVLLSSYGVTGVF 422 Query: 418 TTLAGILVFQAVVFLVFGFETKGRSLEDAS--AVAD 451 L + + A+ G ETKG S+E S AVA+ Sbjct: 423 ILLGAVSIIVAIAIATIGIETKGVSVESLSIDAVAN 458 >Z2813 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 459 Score = 219 bits (559), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 155/456 (33%), Positives = 242/456 (53%), Gaps = 19/456 (4%) Query: 10 NAGARLDRLPICGFHWRILALIGAGMFLDAFDIYLAGGVLGAVLKE-GWSTLELNAAFVS 68 + GARLDRLP C +H + A++ G+ + + GG++ A LK GW+ A F + Sbjct: 8 HCGARLDRLPDCRWHSSMFAIVAFGLLVCWSNA--VGGLILAQLKALGWTDNSTTATFSA 65 Query: 69 ATFVGMTIGAWCSGILGDRFGRRFSYQMNLAIFGLASIAAAFAPNMIVLIGLRFIIGIGL 128 T GM +GA GI+GD+ GRR ++ + AI + + AF+PNM LI RF++G+GL Sbjct: 66 ITTAGMFLGALVGGIIGDKTGRRNAFILYEAIHIASMVVGAFSPNMDFLIACRFVMGVGL 125 Query: 129 GAEIVVGYATLTEFVPASSRGRWIGLLAVITNFSLFVSSMVGLWVIPTL----GWRYMFG 184 GA +V +A TE++P +RG W ++ I N+S + S++ + + P + WR Sbjct: 126 GALLVTLFAGFTEYMPGRNRGTWSSRVSFIGNWSYPLCSLIAMGLTPLISAEWNWRVQLL 185 Query: 185 LVGCLAMVVWFLR-KSMPESPRWLAANGRADEAEKILSAIEAEAAR---KAVLPAVAA-- 238 + L+++ L + PESPRWL + GR EAEK++ +IE R K + P V A Sbjct: 186 IPAILSLIATALAWRYFPESPRWLESRGRYQEAEKVMRSIEEGVIRHTGKPLPPVVIADD 245 Query: 239 -RAPAQESPGAVWRLFQPPYLARTLLGSLLHIVVGFSLYGFIGWLPTFMVKGGHSVVSSL 297 +AP Q P + L L R +LGS + I + Y I WLPT + G ++ S+ Sbjct: 246 GKAP-QAVPYSA--LLTGVLLKRVILGSCVLIAMNVVQYTLINWLPTIFMTQGINLKDSI 302 Query: 298 GYTTVMALGGPVGSVVGLVLADRLGRRLSIVCSSIAAAVLGIAYPYMPDGVALAAVGFLL 357 T+ G P G + +++ D++ R+ V I AVLG Y + + +GF L Sbjct: 303 VLNTMSMFGTPFGIFIAMLVMDKIPRKTMGVGLLILIAVLGYIYSLQTSMLLITLIGFFL 362 Query: 358 ITAIYVMLATGFAMHVPELFPTRYRLRGTAICATSGRIATALVQYVVVAIFAWQGLTGVL 417 IT +Y+ + A++VPE++PT +LRG+ + GRI+ Y V + + G+TGV Sbjct: 363 ITFVYMYVCYASAVYVPEIWPTEAKLRGSGLANAVGRISGIAAPYAVAVLLSSYGVTGVF 422 Query: 418 TTLAGILVFQAVVFLVFGFETKGRSLEDAS--AVAD 451 L + + A+ G ETKG S+E S AVA+ Sbjct: 423 ILLGAVSIIVAIAIATIGIETKGVSVESLSIDAVAN 458