BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0192.p (267 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv2002 [IQR] COG1028 Dehydrogenases with different specificities... 145 8e-35 MT2058 [IQR] COG1028 Dehydrogenases with different specificities... 144 2e-34 mll4921 [IQR] COG1028 Dehydrogenases with different specificitie... 142 7e-34 BS_ywfD [IQR] COG1028 Dehydrogenases with different specificitie... 142 8e-34 SMc01698 [IQR] COG1028 Dehydrogenases with different specificiti... 135 8e-32 >Rv2002 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mtu Mycobacterium tuberculosis H37Rv Length = 260 Score = 145 bits (367), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 100/264 (37%), Positives = 146/264 (55%), Gaps = 27/264 (10%) Query: 1 MSGKSLEGRKALVTGGARGIGAAIAQALARSGAAVMIGDILDDAGKASAAEIAKAGVKTG 60 MSG+ L G+ ALV+GGARG+GA+ +A+ GA V+ GDILD+ GKA AAE+A A Sbjct: 1 MSGR-LIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADA---AR 56 Query: 61 FVKLDVTDDAQWERAAAATVETLGGFDILINNAGIEITSLVADIKAEDARRMCDVNIVGT 120 +V LDVT AQW A V GG +L+NNAGI + D + +R+ DVN+ G Sbjct: 57 YVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGV 116 Query: 121 VLGMKHAFRAMRPGGAAGKGGAVVNIASVAATIAFPSIAVYSGTKSAVDRMTRVGAMEAG 180 LG++ + M+ G G+++NI+S+ + Y+ TK AV +T+ A+E G Sbjct: 117 FLGIRAVVKPMKEAGR----GSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELG 172 Query: 181 KLGYGVRVNCIYPGLIPTDMGLQLANDIVKIGLAPDVNAAVGSVVEQTPLGKLAEVSDIA 240 G+RVN I+PGL+ T M + DI QT LG+ AE +++ Sbjct: 173 P--SGIRVNSIHPGLVKTPMTDWVPEDIF-----------------QTALGRAAEPVEVS 213 Query: 241 DAAVFLCSNDARFITGIGLPVDGG 264 + V+L S+++ + TG VDGG Sbjct: 214 NLVVYLASDESSYSTGAEFVVDGG 237 >MT2058 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MtC Mycobacterium tuberculosis CDC1551 Length = 260 Score = 144 bits (364), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 100/264 (37%), Positives = 146/264 (55%), Gaps = 27/264 (10%) Query: 1 MSGKSLEGRKALVTGGARGIGAAIAQALARSGAAVMIGDILDDAGKASAAEIAKAGVKTG 60 MSG+ L G+ ALV+GGARG+GA+ +A+ GA V+ GDILD+ GKA AAE+A A Sbjct: 1 MSGR-LIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELADA---AR 56 Query: 61 FVKLDVTDDAQWERAAAATVETLGGFDILINNAGIEITSLVADIKAEDARRMCDVNIVGT 120 +V LDVT AQW A V GG +L+NNAGI + D + +R+ DVN+ G Sbjct: 57 YVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGV 116 Query: 121 VLGMKHAFRAMRPGGAAGKGGAVVNIASVAATIAFPSIAVYSGTKSAVDRMTRVGAMEAG 180 LG++ + M+ G G+++NI+S+ + Y+ TK AV +T+ A+E G Sbjct: 117 FLGIRAVVKPMKEAGR----GSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELG 172 Query: 181 KLGYGVRVNCIYPGLIPTDMGLQLANDIVKIGLAPDVNAAVGSVVEQTPLGKLAEVSDIA 240 G+RVN I+PGL+ T M + DI QT LG+ AE +++ Sbjct: 173 P--GGIRVNSIHPGLVKTPMTDWVPEDIF-----------------QTALGRAAEPVEVS 213 Query: 241 DAAVFLCSNDARFITGIGLPVDGG 264 + V+L S+++ + TG VDGG Sbjct: 214 NLVVYLASDESSYSTGAEFVVDGG 237 >mll4921 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Mlo Mesorhizobium loti Length = 256 Score = 142 bits (359), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 102/264 (38%), Positives = 145/264 (54%), Gaps = 13/264 (4%) Query: 6 LEGRKALVTGGARGIGAAIAQALARSGAAVMIGDILDDAGKASAAEIAKAGVKTGFVKLD 65 L+G+ AL+TG ARGIG A A+A AR GA V I DI +A + +AA+I G K VKLD Sbjct: 3 LKGKSALITGSARGIGKAFAEAYAREGAIVAIADINLEAAQKTAADI---GDKAYAVKLD 59 Query: 66 VTDDAQWERAAAATVETLGGFDILINNAGIEITSLVADIKAEDARRMCDVNIVGTVLGMK 125 VTD A + A A GG DILINNA + + + +I ++ VN+ GT+ ++ Sbjct: 60 VTDQASIDAAVKAVETRTGGLDILINNAALFDLAPIVEISRASYEKLFSVNVAGTLFMLQ 119 Query: 126 HAFRAMRPGGAAGKGGAVVNIASVAATIAFPSIAVYSGTKSAVDRMTRVGAMEAGKLGYG 185 A R+M A GKGG ++N+AS A P + VY TK+AV +T+ ++ K + Sbjct: 120 AAARSMI---ARGKGGRIINMASQAGRRGEPLVGVYCATKAAVISLTQSAGLDLIK--HR 174 Query: 186 VRVNCIYPGLIPTDMGLQLANDIVKIGLAP--DVNAAVGSVVEQTPLGKLAEVSDIADAA 243 + VN I PG++ +DM Q+ K P + VG E P G++ + D+A A Sbjct: 175 INVNGIAPGVVDSDMWDQVDALFAKYENRPKGEKKRLVG---EGVPYGRMGKPEDLAGMA 231 Query: 244 VFLCSNDARFITGIGLPVDGGMGM 267 VFL S++A +I VDGG M Sbjct: 232 VFLASDEAEYIVAQTYNVDGGQWM 255 >BS_ywfD [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bsu Bacillus subtilis Length = 255 Score = 142 bits (358), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 90/262 (34%), Positives = 145/262 (55%), Gaps = 16/262 (6%) Query: 5 SLEGRKALVTGGARGIGAAIAQALARSGAAVMIGDILDDAGKASAAEIAKAGVKTGFVKL 64 +L + L+TGGA GIG A QA A V++ DI + G+A + + + FV+ Sbjct: 4 NLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEAMVRK--ENNDRLHFVQT 61 Query: 65 DVTDDAQWERAAAATVETLGGFDILINNAGIEITSLVADIKAEDARRMCDVNIVGTVLGM 124 D+TD+A + A + V T GG D+LINNAGIEI + + +++ D ++ VN+ G L Sbjct: 62 DITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLMS 121 Query: 125 KHAFRAMRPGGAAGKGGAVVNIASVAATIAFPSIAVYSGTKSAVDRMTRVGAMEAGKLGY 184 KHA + M AAGKG ++N SV +A+P I Y+ +K V ++T+ A++ K + Sbjct: 122 KHALKHML---AAGKGN-IINTCSVGGLVAWPDIPAYNASKGGVLQLTKSMAVDYAK--H 175 Query: 185 GVRVNCIYPGLIPTDMGLQ--LANDIVKIGLAPDVNAAVGSVVEQTPLGKLAEVSDIADA 242 +RVNC+ PG+I T + + L N+ G ++ V PL +L + +IA+ Sbjct: 176 QIRVNCVCPGIIDTPLNEKSFLENN---EGTLEEIKKEKAKV---NPLLRLGKPEEIANV 229 Query: 243 AVFLCSNDARFITGIGLPVDGG 264 +FL S+ + ++TG + DGG Sbjct: 230 MLFLASDLSSYMTGSAITADGG 251 >SMc01698 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Sme Sinorhizobium meliloti Length = 251 Score = 135 bits (341), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 93/259 (35%), Positives = 136/259 (52%), Gaps = 18/259 (6%) Query: 6 LEGRKALVTGGARGIGAAIAQALARSGAAVMIGDILDDAGKASAAEIAKAGVKTGFVKLD 65 LEG+ A+VTG GIGAA+++ L GA V++ D DA ++ AAEI AG + +D Sbjct: 5 LEGKIAIVTGAGSGIGAAVSRQLGGEGAEVIVADRDADAARSVAAEIRSAGGRARDFTVD 64 Query: 66 VTDDAQWERAAAATVETLGGFDILINNAGIE-ITSLVADIKAEDARRMCDVNIVGTVLGM 124 VTD E+ A TV GG + +NNAGIE AD ED RR+ +VN+ G M Sbjct: 65 VTDAGAVEQMVAFTVRECGGLHLAVNNAGIEGPRQATADYPLEDWRRLIEVNLNGVFYCM 124 Query: 125 KHAFRAMRPGGAAGKGGAVVNIASVAATIAFPSIAVYSGTKSAVDRMTRVGAMEAGKLGY 184 K+ AM G GGA+VN++S+ +A P+ + Y+ K V +T+ +E ++ Sbjct: 125 KYEIAAMLGKG----GGAIVNMSSILGAVALPTASAYTAAKHGVVGLTKAAGIEYARM-- 178 Query: 185 GVRVNCIYPGLIPTDMGLQLANDIVKIGLAPDVNAAVGSVVEQTPLGKLAEVSDIADAAV 244 G+R+N + PG I T + L +++ K + PLG+ + ++A Sbjct: 179 GIRINAVGPGWIETPL-LSGHSELAKTRRLEALQ----------PLGRRGKPEEVAALVC 227 Query: 245 FLCSNDARFITGIGLPVDG 263 FL S A FITG PVDG Sbjct: 228 FLLSEQASFITGSYHPVDG 246