BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0033.0080.p (465 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3467 [GEPR] COG0477 Permeases of the major facilitator superfa... 125 2e-28 yaaU [GEPR] COG0477 Permeases of the major facilitator superfami... 110 5e-24 ZyaaU [GEPR] COG0477 Permeases of the major facilitator superfam... 110 6e-24 ECs0048 [GEPR] COG0477 Permeases of the major facilitator superf... 110 6e-24 PAE2330 [GEPR] COG0477 Permeases of the major facilitator superf... 108 3e-23 >PA3467 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 455 Score = 125 bits (315), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 133/454 (29%), Positives = 202/454 (44%), Gaps = 36/454 (7%) Query: 4 DEAPVTARYWLSIIIFAVTGVVDFFDFFVVGFLVSVLAPKWHLTFGQTSIMLMSAGIGAM 63 + P++ + L +I A+ D D ++ FL+ + ++ L Q ++ S+ G + Sbjct: 13 ERLPLSPYHRLVFVIIALAFFFDSMDLAMMTFLLGSIKAEFGLDSAQAGLLASSSFFGMV 72 Query: 64 LGAFVAGVLADRFGRKPLAISGVLLCGLTSGAIAFIPEDGWVAFAILRFFVGFGLAAGAA 123 +GA ++G+LADRFGRKP+ + ++L GL S + + + F R +G G+ Sbjct: 73 IGAALSGMLADRFGRKPVFQASIVLWGLASYLCSTAGDLDSLTF--YRVLLGIGMGMEFP 130 Query: 124 AAVPAIVEFAPTRHRTLVTSLVVVPIALGVLSASVTASFLLPLVGWRGLAAVGFLPIILG 183 A + E P R +L+ LG ++A + FLLPL GWR + V LP + Sbjct: 131 IAQSLLSEMIPASRRGKYIALMDGFWPLGFVAAGCLSYFLLPLTGWRSIFLVLALPAVFV 190 Query: 184 ILTMIIMPESPRWLISKGRVREAQASIRKLYRVGGDAFALPTLPP--------VSSATFV 235 + ++PESPRWL GR +A +R + + L LPP S F Sbjct: 191 LAIRFLIPESPRWLEQAGRREQADRVLRDIEARVMRSLGLTELPPPLRQPQRERSRPGFF 250 Query: 236 DLFAE-----QRRFWLTVL-IWFGASTANYGVFLWGPTIVALLL--GVSPQDAAKMFIYV 287 FAE RR LTV +WF A YG+ W + ALL G + + + + Sbjct: 251 SAFAELWSPAYRRRTLTVWGLWFFALLGFYGLTSW---LSALLQQSGFAVTQSVYYTVLI 307 Query: 288 SLAGVFGRTGFAFLAHRIGRKPCGQLMGYGTAVSLALAAYFHNDFAGTVPLFLVFLIVGA 347 SLAG+ G A+L GRKP LM G ++A A F G++ L + F + Sbjct: 308 SLAGIPGFLCAAWLVESWGRKPSCVLMLLGGG-AMAYAYGQTAVFGGSLALLIGFGLAMQ 366 Query: 348 VFFDGGFSNIGPYPAEIFPVQLSGRAVGLAQLSNGIGKIVGPLCLALIAGADNLVHPSAT 407 F G ++ + Y E++P G A IG ++GPL LV P Sbjct: 367 FFLFGMWAVLYTYTPELYPTSARATGSGFASAVGRIGSLLGPLV-------TGLVLPLTG 419 Query: 408 AAAV--MPAFCFLAGAGLLIGLAFTFLGVEPHGR 439 V + A CF G L+ AF G+E GR Sbjct: 420 QGGVFTLGALCF--GVAALVVWAF---GIETRGR 448 >yaaU [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 443 Score = 110 bits (276), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 112/381 (29%), Positives = 176/381 (46%), Gaps = 32/381 (8%) Query: 25 VDFFDFFVVGFLVSVLAPKWHLTFGQTSIMLMSAGI--GAMLGAFVAGVLADRFGRKPLA 82 +D + ++G + L P L I L+ AG G +G + G ++D+ GR+ + Sbjct: 29 LDGYVLVMIGVALEQLTPA--LKLDADWIGLLGAGTLAGLFVGTSLFGYISDKVGRRKMF 86 Query: 83 ISGVLLCGLTSGAIAFIPEDGWVAFAILRFFVGFGLAAGAAAAVPAIVEFAPTRHRTLVT 142 + ++ G+ S A F+ V ++R +G + A A I EF+ TR R Sbjct: 87 LIDIIAIGVISVATMFVSSP--VELLVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSI 144 Query: 143 SLVVVPIALGVLSASVTASFLLPLVG-WRGLAAVGFLPIILGILTMIIMPESPRWLISKG 201 S + +G A + +L + G WR + +P +L ++ +PESPRWL+ KG Sbjct: 145 SFIAAMWYVGATCADLVGYWLYDVEGGWRWMLGSAAIPCLLILIGRFELPESPRWLLRKG 204 Query: 202 RVREAQASIRKLYRVGGDAFALPTLPPVSSATFVDLFAEQRRFWLTVL----IWFGASTA 257 RV+E + + KL+ G+ A P F DLF RR + VL IW Sbjct: 205 RVKECEEMMIKLF---GEPVAFDEEQP-QQTRFRDLF--NRRHFPFVLFVAAIWTCQVIP 258 Query: 258 NYGVFLWGPTIVALL-LGVSPQDAAKMFIYVSLAGVFGRTGFAFLAHRIGRKPCGQLMGY 316 + ++ +GP IV LL LGV ++AA + +SL + G + GR+P L+G Sbjct: 259 MFAIYTFGPQIVGLLGLGVG-KNAALGNVVISLFFMLGCIPPMLWLNTAGRRPL--LIGS 315 Query: 317 GTAVSLALAAYFHNDFAGTVPLFLVFLIVGA----VFFDGGFSNIG-PYPAEIFPVQLSG 371 ++LALA G +P ++L+V A FF GG N+ YP E+FP + Sbjct: 316 FAMMTLALAVL------GLIPDMGIWLVVMAFAVYAFFSGGPGNLQWLYPNELFPTDIRA 369 Query: 372 RAVGLAQLSNGIGKIVGPLCL 392 AVG+ + IG IV L Sbjct: 370 SAVGVIMSLSRIGTIVSTWAL 390 >ZyaaU [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 443 Score = 110 bits (276), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 112/381 (29%), Positives = 176/381 (46%), Gaps = 32/381 (8%) Query: 25 VDFFDFFVVGFLVSVLAPKWHLTFGQTSIMLMSAGI--GAMLGAFVAGVLADRFGRKPLA 82 +D + ++G + L P L I L+ AG G +G + G ++D+ GR+ + Sbjct: 29 LDGYILVMIGVALEQLTPA--LKLDADWIGLLGAGTLAGLFVGTSLFGYISDKVGRRKMF 86 Query: 83 ISGVLLCGLTSGAIAFIPEDGWVAFAILRFFVGFGLAAGAAAAVPAIVEFAPTRHRTLVT 142 + ++ G+ S A F+ V ++R +G + A A I EF+ TR R Sbjct: 87 LIDIIAIGVISVATMFVSSP--VELLVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSI 144 Query: 143 SLVVVPIALGVLSASVTASFLLPLVG-WRGLAAVGFLPIILGILTMIIMPESPRWLISKG 201 S + +G A + +L + G WR + +P +L ++ +PESPRWL+ KG Sbjct: 145 SFIAAMWYVGATCADLVGYWLYDVEGGWRWMLGSAAIPCLLILIGRFELPESPRWLLRKG 204 Query: 202 RVREAQASIRKLYRVGGDAFALPTLPPVSSATFVDLFAEQRRFWLTVL----IWFGASTA 257 RV+E + + KL+ G+ A P F DLF RR + VL IW Sbjct: 205 RVKECEEMMIKLF---GEPVAFDEEQP-QQTRFRDLF--NRRHFPFVLFVAAIWTCQVIP 258 Query: 258 NYGVFLWGPTIVALL-LGVSPQDAAKMFIYVSLAGVFGRTGFAFLAHRIGRKPCGQLMGY 316 + ++ +GP IV LL LGV ++AA + +SL + G + GR+P L+G Sbjct: 259 MFAIYTFGPQIVGLLGLGVG-KNAALGNVVISLFFMLGCIPPMLWLNTAGRRPL--LIGS 315 Query: 317 GTAVSLALAAYFHNDFAGTVPLFLVFLIVGA----VFFDGGFSNIG-PYPAEIFPVQLSG 371 ++LALA G +P ++L+V A FF GG N+ YP E+FP + Sbjct: 316 FAMMTLALAVL------GLIPDMGIWLVVMAFAVYAFFSGGPGNLQWLYPNELFPTDIRA 369 Query: 372 RAVGLAQLSNGIGKIVGPLCL 392 AVG+ + IG IV L Sbjct: 370 SAVGVIMSLSRIGTIVSTWAL 390 >ECs0048 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 443 Score = 110 bits (276), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 112/381 (29%), Positives = 176/381 (46%), Gaps = 32/381 (8%) Query: 25 VDFFDFFVVGFLVSVLAPKWHLTFGQTSIMLMSAGI--GAMLGAFVAGVLADRFGRKPLA 82 +D + ++G + L P L I L+ AG G +G + G ++D+ GR+ + Sbjct: 29 LDGYILVMIGVALEQLTPA--LKLDADWIGLLGAGTLAGLFVGTSLFGYISDKVGRRKMF 86 Query: 83 ISGVLLCGLTSGAIAFIPEDGWVAFAILRFFVGFGLAAGAAAAVPAIVEFAPTRHRTLVT 142 + ++ G+ S A F+ V ++R +G + A A I EF+ TR R Sbjct: 87 LIDIIAIGVISVATMFVSSP--VELLVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSI 144 Query: 143 SLVVVPIALGVLSASVTASFLLPLVG-WRGLAAVGFLPIILGILTMIIMPESPRWLISKG 201 S + +G A + +L + G WR + +P +L ++ +PESPRWL+ KG Sbjct: 145 SFIAAMWYVGATCADLVGYWLYDVEGGWRWMLGSAAIPCLLILIGRFELPESPRWLLRKG 204 Query: 202 RVREAQASIRKLYRVGGDAFALPTLPPVSSATFVDLFAEQRRFWLTVL----IWFGASTA 257 RV+E + + KL+ G+ A P F DLF RR + VL IW Sbjct: 205 RVKECEEMMIKLF---GEPVAFDEEQP-QQTRFRDLF--NRRHFPFVLFVAAIWTCQVIP 258 Query: 258 NYGVFLWGPTIVALL-LGVSPQDAAKMFIYVSLAGVFGRTGFAFLAHRIGRKPCGQLMGY 316 + ++ +GP IV LL LGV ++AA + +SL + G + GR+P L+G Sbjct: 259 MFAIYTFGPQIVGLLGLGVG-KNAALGNVVISLFFMLGCIPPMLWLNTAGRRPL--LIGS 315 Query: 317 GTAVSLALAAYFHNDFAGTVPLFLVFLIVGA----VFFDGGFSNIG-PYPAEIFPVQLSG 371 ++LALA G +P ++L+V A FF GG N+ YP E+FP + Sbjct: 316 FAMMTLALAVL------GLIPDMGIWLVVMAFAVYAFFSGGPGNLQWLYPNELFPTDIRA 369 Query: 372 RAVGLAQLSNGIGKIVGPLCL 392 AVG+ + IG IV L Sbjct: 370 SAVGVIMSLSRIGTIVSTWAL 390 >PAE2330 [GEPR] COG0477 Permeases of the major facilitator superfamily Pya Pyrobaculum aerophilum Length = 384 Score = 108 bits (270), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 40/381 (10%) Query: 26 DFFDFFVVGFLVSVLAPKWHLTFGQTSIMLMSAGIGAMLGAFVAGVLADRFGRKPLAISG 85 D D ++ +L+ ++ + L + ++++ +G ++GA + G LADR GRK + +S Sbjct: 17 DALDVLILSYLLVAMSNELKLDSQAKNWIVLANNLGMLIGAMLFGRLADRVGRKKVFMST 76 Query: 86 VLLCGLTSGAIAFIPEDGWVAFAILRFFVGFGLAAGAAAAVPAIVEFAPTRHRTLVTSLV 145 +L + + AF W FA++RFFVG GL + E +P R L+ Sbjct: 77 LLTYSIATAISAF--ARNWQEFAVIRFFVGLGLGGELPVVATYVSENSPPERRGRNVVLL 134 Query: 146 VVPIALGVLSASVTASFLLPLVGWRG----LAAVGFLPIILGILTMIIMPESPRWLISKG 201 +LG + A+ + FL +GWR + A F ++ +PES RWL Sbjct: 135 ESFWSLGAILAAAISLFLFTTIGWRSSLLLMGATAFYVFVI----RFTLPESQRWL---- 186 Query: 202 RVREAQASIRKLYRVGGDAFALPTLPPVSSATFVDLFAEQRRFWLTVLIWFGASTANYGV 261 +RE + + + R+ G+ FV RR L +WF + YG Sbjct: 187 ELREQRGGLFET-RIIGE--------------FV------RRLTLVGAVWFLLAFGYYGA 225 Query: 262 FLWGPTIVALLLGVSPQDAAKMFIYVSLAGVFGRTGFAFLAHRIGRKPCGQLMGYGTAVS 321 FLW PT++ G + + +LA + G A+L + GR+P G L +A+S Sbjct: 226 FLWLPTMLVRERGFTQVGTYEFMFLTTLAQLPGYFSAAYLVEKAGRRPVGSLYFALSALS 285 Query: 322 LALAAYFHNDFAGTVPLFLVFLIVGAVFFDGGFSNIGPYPAEIFPVQLSGRAVGLAQLSN 381 AA+F + + + L++ + F G + + Y E+FP + G A GLA + Sbjct: 286 ---AAFFIS--SNSYAELLLWALALNFFNLGVWGVVYAYTPELFPTSVRGIATGLAGSAA 340 Query: 382 GIGKIVGPLCLALIAGADNLV 402 IG I+GPL L A L+ Sbjct: 341 RIGMILGPLLYPLYASTALLI 361