BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0033.0072.p (437 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value STM1107 [GEPR] COG0477 Permeases of the major facilitator superf... 306 4e-83 YPO1768 [GEPR] COG0477 Permeases of the major facilitator superf... 293 4e-79 RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 283 8e-76 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 264 3e-70 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 258 2e-68 >STM1107 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 458 Score = 306 bits (785), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 168/436 (38%), Positives = 257/436 (58%), Gaps = 15/436 (3%) Query: 3 EVVMDKAAIATADPEIERSTIRKVALRLMWFVMAMYFLAILDRGNISFAALQMNKELGLN 62 E V A++T +++ I K+ RL+ F+ ++ + LDR NI FA L M ++LGL+ Sbjct: 13 ESVSSHNALSTG----QQTVINKLFRRLIVFLFVLFIFSFLDRINIGFAGLTMGQDLGLS 68 Query: 63 AEKFGIAVGIMYFTYSIFEIPSNLILSKYGARVTLTRIAILWGIATVLMAFTQGPLSLYA 122 A FG+A + Y TY IF IPSN++LS GAR + I +LWGIA+ F GP SLY Sbjct: 69 ATMFGLATTLFYATYVIFGIPSNVMLSIVGARHWIATIMVLWGIASTATMFAVGPKSLYV 128 Query: 123 FRGFLGFAESGLFPGVMLLLSLWFPFSYRARYNAMFNYAVPISYIFASLISGAILELNGV 182 R +G E+G PG++L L+ WFP +RAR NA+F A+P + S++SG IL L+G+ Sbjct: 129 LRMLVGITEAGFLPGILLYLTYWFPAFFRARANALFMIAMPATTALGSIVSGYILSLDGI 188 Query: 183 FGISGWKWLFILEGLPPVILGIVGIFYLTDRPQQASWLSAAQRNWLIGALERD------- 235 F + GW+WLF+LEG P V+LGI+ FYL D P +A WL+A + L ++ D Sbjct: 189 FNLHGWQWLFLLEGFPSVLLGIMVWFYLDDTPAKAKWLTAEDKKCLQEMMDSDRLTLVQP 248 Query: 236 --AKATGVVHAEGVLRTITKPMVLLFGLCNFGLFCGLASLFPWLPQIIKSF--GLPNSQV 291 A + + + R + P+VL++ L F L L+++ W PQI+KSF G N + Sbjct: 249 EGAISHNAMQQRSLWREVFTPIVLMYTLAYFCLTNTLSAISIWTPQILKSFNEGSSNITI 308 Query: 292 GFVTAIPPVAGLIGMIALSRHSDHVGERFYYAAMTFVIAAAGFAIAAFSTSPVWIIIGFM 351 G + AIP + ++GMI SRHSD ER ++ A+ F+ AAAG+ +A+ + + ++G + Sbjct: 309 GLLAAIPQICTILGMIYWSRHSDKHQERKHHTALPFLFAAAGWLLASATDHNLIQLLGIV 368 Query: 352 VANVGVYGTQAVFWTIPQSYMSRQSAPGAIGLVSTIGSIGGATIPIVIGRAKDASGSFTV 411 +A+ G + A+FWT P +S ++ I +++ G+IG A P +IG KD +GSF Sbjct: 369 MASTGSFSAMAIFWTTPDQSISLRARAIGIAVINATGNIGSALSPFMIGWLKDITGSFNS 428 Query: 412 GFLVVTGVLLVAAILV 427 G V +L+V A ++ Sbjct: 429 GLWFVASLLVVGAAII 444 >YPO1768 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 455 Score = 293 bits (751), Expect = 4e-79, Method: Compositional matrix adjust. Identities = 167/419 (39%), Positives = 251/419 (59%), Gaps = 8/419 (1%) Query: 19 ERSTIRKVALRLMWFVMAMYFLAILDRGNISFAALQMNKELGLNAEKFGIAVGIMYFTYS 78 ++S I K+ RL+ F+ ++ A LDR NI FA L M K+LGL+A FG+A + Y TY Sbjct: 25 QQSVINKLFRRLIPFLFLLFVFAFLDRINIGFAGLTMGKDLGLSATTFGLATTLFYVTYI 84 Query: 79 IFEIPSNLILSKYGARVTLTRIAILWGIATVLMAFTQGPLSLYAFRGFLGFAESGLFPGV 138 +F IPSN++L GAR + I +LWGIA+ F GP SLY R +G E+G PG+ Sbjct: 85 LFAIPSNIMLGIVGARRWIATIMVLWGIASTATLFAVGPNSLYLLRMIVGITEAGFLPGI 144 Query: 139 MLLLSLWFPFSYRARYNAMFNYAVPISYIFASLISGAILELNGVFGISGWKWLFILEGLP 198 ++ L+ WFP +RAR NA+F A+P++ SL+SG IL L+G + GW+WLF+LEG P Sbjct: 145 LVYLTYWFPAHFRARANALFMVAMPVTMALGSLVSGYILALDGFLNMRGWQWLFLLEGFP 204 Query: 199 PVILGIVGIFYLTDRPQQASWLSAAQRNWLIGALERD----AKAT--GVVHAEGVLRTIT 252 V+LG V FYL D PQ+A WL+ + L LE D AK G + + R I Sbjct: 205 SVLLGGVVWFYLDDTPQKARWLTKEDKQCLQEMLESDRLQLAKQADYGALPQSAMWREIF 264 Query: 253 KPMVLLFGLCNFGLFCGLASLFPWLPQIIKSFGLPNSQ--VGFVTAIPPVAGLIGMIALS 310 P+VL++ L F L L+++ W PQI++SF +S +G + AIP V + GMI S Sbjct: 265 TPVVLMYTLAYFCLTNTLSAVNIWTPQILQSFNQSSSNITIGLLAAIPQVCTIAGMIWWS 324 Query: 311 RHSDHVGERFYYAAMTFVIAAAGFAIAAFSTSPVWIIIGFMVANVGVYGTQAVFWTIPQS 370 R SD V ER + + ++ AAAG+ +A+ + + V ++G ++A+ G + A+FWT P Sbjct: 325 RRSDRVQERKMHTVLPYLFAAAGWVLASATQNSVIQLLGIIMASTGSFTAMAIFWTTPDQ 384 Query: 371 YMSRQSAPGAIGLVSTIGSIGGATIPIVIGRAKDASGSFTVGFLVVTGVLLVAAILVLI 429 +S ++ I +++ G+IG A P++IG KD +G+F G V G+L++ A++ L+ Sbjct: 385 SISLRARAVGIAVINATGNIGSAVSPVLIGWLKDQTGNFNSGLYFVAGLLVIGAVIFLM 443 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 283 bits (723), Expect = 8e-76, Method: Compositional matrix adjust. Identities = 163/425 (38%), Positives = 246/425 (57%), Gaps = 3/425 (0%) Query: 9 AAIATADPEIERSTIRKVALRLMWFVMAMYFLAILDRGNISFAALQMNKELGLNAEKFGI 68 AA A P+ ER+ +RK+ R++ FV A+Y ++ LDR NI +AALQMN+EL L++E FG Sbjct: 17 AARHPAAPD-ERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGF 75 Query: 69 AVGIMYFTYSIFEIPSNLILSKYGARVTLTRIAILWGIATVLMAFTQGPLSLYAFRGFLG 128 GI + Y +FE+PSNL+L+++GAR + RI + WG+ + AF Q LYA R LG Sbjct: 76 VSGIFFIGYFLFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLG 135 Query: 129 FAESGLFPGVMLLLSLWFPFSYRARYNAMFNYAVPISYIFASLISGAILELNGVFGISGW 188 AE+G FPG+++ L+ WF A A+F A+P+SY+ + +S I++ SGW Sbjct: 136 VAEAGFFPGIIVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWIMDHVHWLQWSGW 195 Query: 189 KWLFILEGLPPVILGIVGIFYLTDRPQQASWLSAAQRNWLIGALERDAKATGVVHAEGVL 248 +W+ +LEG P VI G++ YL DRP+ A WLS A+R+WL+ LERD KA L Sbjct: 196 RWMLLLEGAPAVIGGLLCYGYLADRPKDARWLSEAERDWLLAELERDRKARPAAAHLATL 255 Query: 249 RTITKPMVLLFGLCNFGLFCGLASLFPWLPQIIKSF--GLPNSQVGFVTAIPPVAGLIGM 306 + +T P VL F CG + W+PQIIK F L +++VG + +P V M Sbjct: 256 KVMTHPRVLYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVM 315 Query: 307 IALSRHSDHVGERFYYAAMTFVIAAAGFAIAAFSTSPVWIIIGFMVANVGVYGTQAVFWT 366 I SR SD ER ++A+ +AA F A F P + ++ G+Y ++ FW Sbjct: 316 IWWSRRSDLRAERRLHSAVPLGVAALAFVGAGFIGHPAVAMAMLSLSLAGLYAFKSPFWA 375 Query: 367 IPQSYMSRQSAPGAIGLVSTIGSIGGATIPIVIGRAKDASGSFTVGFLVVTGVLLVAAIL 426 +P +++R +A +I +++++G++GG P IG K S T G L + G+L V+ ++ Sbjct: 376 LPTLFLTRSTAAVSIAVINSVGNLGGFVGPFAIGYFKGQMHSTTAGLLFLAGLLAVSFVM 435 Query: 427 VLIAR 431 L R Sbjct: 436 TLRLR 440 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 264 bits (675), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 157/411 (38%), Positives = 230/411 (55%), Gaps = 8/411 (1%) Query: 6 MDKAAIATADPEIERST--IRKVALRLMWFVMAMYFLAILDRGNISFAALQMNKELGLNA 63 M AI ERST V R++ F+ Y A LDR NI FA LQM +L L+ Sbjct: 1 MAANAIPAQAHSGERSTSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSD 60 Query: 64 EKFGIAVGIMYFTYSIFEIPSNLILSKYGARVTLTRIAILWGIATVLMAFTQGPLSLYAF 123 +G+ GI +F Y +FE+PSNL+L K GAR TL+RI ILWGI + M F + YA Sbjct: 61 AAYGLGAGIFFFGYMLFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYAL 120 Query: 124 RGFLGFAESGLFPGVMLLLSLWFPFSYRARYNAMFNYAVPISYIFASLISGAIL-ELNGV 182 R LG E+G PG++ L+ W+P AR A+ A P+ + S I+ G Sbjct: 121 RFLLGVFEAGFAPGMIYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGA 180 Query: 183 FGISGWKWLFILEGLPPVILGIVGIFYLTDRPQQASWLSAAQRNWLIGALERDAKATGVV 242 G++GW+W+F+ EG+P ++LGI YL D+P A WL+ AQ+ + G + R A Sbjct: 181 GGLAGWQWMFLAEGIPSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIARAAPG---- 236 Query: 243 HAEGVLRTITKPMVLLFGLCNFGLFCGLASLFPWLPQIIKSFGLPNS-QVGFVTAIPPVA 301 A + +T+P + + F L CG+ ++ WLP I+KS GL + Q+G +AIP +A Sbjct: 237 QASSFGKALTEPKLYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLA 296 Query: 302 GLIGMIALSRHSDHVGERFYYAAMTFVIAAAGFAIAAFSTSPVWIIIGFMVANVGVYGTQ 361 ++ M AL R SD GER ++A+T V+ A A AA++TS +I +A+ ++ + Sbjct: 297 MIVAMYALGRRSDRRGERHLHSAITAVLGAGLLAWAAYATSFPAALISITLASAAIFASY 356 Query: 362 AVFWTIPQSYMSRQSAPGAIGLVSTIGSIGGATIPIVIGRAKDASGSFTVG 412 +VFW IPQ ++ +A G I L+++IG GG P +IG K+A+GS G Sbjct: 357 SVFWAIPQQHLKGTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGSLQAG 407 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 258 bits (659), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 156/441 (35%), Positives = 247/441 (56%), Gaps = 9/441 (2%) Query: 1 MTEVVMDKAAIATADPEIERSTIRKVALRLMWFVMAMYFLAILDRGNISFAALQMNKELG 60 M+E + + T E E + RK L+ +M Y L LDR N+ FA LQM +L Sbjct: 1 MSESSTESLSQPTQLQE-ENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQ 59 Query: 61 LNAEKFGIAVGIMYFTYSIFEIPSNLILSKYGARVTLTRIAILWGIATVLMAFTQGPLSL 120 + +G+ G+ + Y EIPSNLIL + GAR+ + RI I WGI + MAF P+S Sbjct: 60 FSDTVYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSF 119 Query: 121 YAFRGFLGFAESGLFPGVMLLLSLWFPFSYRARYNAMFNYAVPISYIFASLISGAILE-L 179 Y R LG AE+G FPG++L +S WFP R R +F +VP+S I + +SG I++ Sbjct: 120 YVMRFLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYF 179 Query: 180 NGVFGISGWKWLFILEGLPPVILGIVGIFYLTDRPQQASWLSAAQRNWLIGALERDAKAT 239 NG G +GW+W+FILEG+P V++GI+ I+ L DR A+WL+ +++ L +E +A Sbjct: 180 NGFQGYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAH- 238 Query: 240 GVVHAEGVLRT-ITKPMVLLFGLCNFGLFCGLASLFPWLPQIIKSFGLPN-SQVGFVTAI 297 +A LR +P V L L F L G ++ WLP +I+ G+ + +GF+TAI Sbjct: 239 ---YAHSRLRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAI 295 Query: 298 PPVAGLIGMIALSRHSDHVGERFYYAAMTFVIAAAGFAIAA-FSTSPVWIIIGFMVANVG 356 P A + MI +SR +D + ER ++ A+T V+ A G ++ FS + V ++ + +G Sbjct: 296 PSAAAAVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMG 355 Query: 357 VYGTQAVFWTIPQSYMSRQSAPGAIGLVSTIGSIGGATIPIVIGRAKDASGSFTVGFLVV 416 T +FW++P +++ +A I +++ G++GG P ++G KD + S T G L++ Sbjct: 356 ALSTIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLII 415 Query: 417 TGVLLVAAILVLIARSQLVKE 437 + L + A LV + ++ V Sbjct: 416 STTLFIGAALVFLIPAKAVNH 436