BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0033.0051.p (281 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3071 [R] COG1721 Uncharacterized conserved protein (some membe... 163 3e-40 VCA0174 [R] COG1721 Uncharacterized conserved protein (some memb... 129 6e-30 Rv1480 [R] COG1721 Uncharacterized conserved protein (some membe... 89 1e-17 MT1527 [R] COG1721 Uncharacterized conserved protein (some membe... 88 2e-17 ML1809 [R] COG1721 Uncharacterized conserved protein (some membe... 85 2e-16 >PA3071 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) Pae Pseudomonas aeruginosa Length = 312 Score = 163 bits (413), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 91/260 (35%), Positives = 152/260 (58%), Gaps = 1/260 (0%) Query: 1 MRGRGLNFEEIRDYRPGDDVREIDWKVTARLQKPHVRVFNEERDRQALLVVDQRLSMFFG 60 +RGRG++F+++R Y+PGDDVR IDW+VTAR ++PH ++F+EER+R ++V+Q +FFG Sbjct: 45 LRGRGVDFDQVRIYQPGDDVRTIDWRVTARTREPHTKLFHEERERPVFVLVEQSQRLFFG 104 Query: 61 SRRAMKSVTAAETAAIGAWRVLGVGDRVGAIVFNDSDVVELAARRSRATVLQILSTIVAQ 120 S K+V AA AA W L DR+G +VF+D D E+ RRS+ ++LQ+ + ++ Sbjct: 105 SGLCFKAVLAARAAAFIGWSALAHNDRIGGLVFSDRDCHEIKPRRSKHSLLQLFNQLLRA 164 Query: 121 NQALGVGRGLVPASGMLNRALERAERRTMHDATVILISDFDGADAATRRMIGAIARHNNV 180 N+ L P + AL RA + ++++ D + + + IARH ++ Sbjct: 165 NRELRETPAERPGE-LFGLALRRAREVLRPGSLILVLCDERTLNDVAEQQLSLIARHTDL 223 Query: 181 VAVLVHDPLQSDLPASSRMTVTDGELQIQLEVGRESVRKSIAQASQERLRGVFAWTRELG 240 V + + DPL LPA+ + +G ++L+ + +R++ + ++ R + LG Sbjct: 224 VLLPLSDPLDHALPAAGLLRFREGAADLELDTHADELRQAYRELAEARRARWQRLAQRLG 283 Query: 241 IPVLPLSTAEETAPQLRRLL 260 +P+LPLST E+ QLR LL Sbjct: 284 VPLLPLSTQEDLVEQLRDLL 303 >VCA0174 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) Vch Vibrio cholerae Length = 311 Score = 129 bits (325), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 72/189 (38%), Positives = 107/189 (56%), Gaps = 2/189 (1%) Query: 3 GRGLNFEEIRDYRPGDDVREIDWKVTARLQKPHVRVFNEERDRQALLVVDQRLSMFFGSR 62 GRG++F E+R Y+ GDD+R IDW+VTAR KPH ++F+EER+R +L +D SM FGS Sbjct: 52 GRGMDFSEVRQYQAGDDIRTIDWRVTARTGKPHTKLFSEERERTVVLYIDLSPSMQFGSC 111 Query: 63 RAMKSVTAAETAAIGAWRVLGVGDRVGAIVFNDSDVVELAARRSRATVLQILSTIVAQNQ 122 +KSV AA A++ +W + DRVGA++ ++E+ + VL IL+ V Q Sbjct: 112 LLLKSVQAAHLASLLSWLAVKQQDRVGAVIDLGHRLIEIKPGSRQRGVLTILAACVEAQQ 171 Query: 123 ALGVGRGLVPASGMLNRALERAERRTMHDATVILISDFDGADAATRRM-IGAIARHNNVV 181 + + + L+ L R D+ V+LISDF D + + + RHN V Sbjct: 172 HIPPTQP-TTRTLALHEVLSTLNRLCPKDSEVVLISDFVDLDTEQHALSLRQLCRHNRVQ 230 Query: 182 AVLVHDPLQ 190 V +HDPL+ Sbjct: 231 LVQIHDPLE 239 >Rv1480 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) Mtu Mycobacterium tuberculosis H37Rv Length = 317 Score = 88.6 bits (218), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/203 (35%), Positives = 99/203 (48%), Gaps = 7/203 (3%) Query: 3 GRGLNFEEIRDYRPGDDVREIDWKVTARLQKPHVRVFNEERDRQALLVVDQRLSMFFGSR 62 G G E R Y+PGDDVR +DW VTAR PHVR +R+ + LVVD S+ FG+ Sbjct: 54 GPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDMSASLDFGTA 113 Query: 63 RAMKSVTAAETAAIGAWRVLGVGDRVGAIVFNDSDVVELAARRSRATVLQILSTIVAQNQ 122 K A AA + G G+R+GA++ N + + + AR R +L TI Q Sbjct: 114 CCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHTMLRTIATMPQ 173 Query: 123 ALGVGRGLVPASGMLNRALERAERRTMHDATVILISDFDGADAATRRMIGAIARHNNVVA 182 A RG + + AL R ERR ++ISDF G R + ARH V+A Sbjct: 174 APAGVRGDL---AVAIDALRRPERRR---GMAVIISDFLGPINWMRPLRAIAARH-EVLA 226 Query: 183 VLVHDPLQSDLPASSRMTVTDGE 205 + V DP +LP + + D E Sbjct: 227 IEVLDPRDVELPDVGDVVLQDAE 249 >MT1527 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) MtC Mycobacterium tuberculosis CDC1551 Length = 303 Score = 88.2 bits (217), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 73/203 (35%), Positives = 99/203 (48%), Gaps = 7/203 (3%) Query: 3 GRGLNFEEIRDYRPGDDVREIDWKVTARLQKPHVRVFNEERDRQALLVVDQRLSMFFGSR 62 G G E R Y+PGDDVR +DW VTAR PHVR +R+ + LVVD S+ FG+ Sbjct: 40 GPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDMSASLDFGTA 99 Query: 63 RAMKSVTAAETAAIGAWRVLGVGDRVGAIVFNDSDVVELAARRSRATVLQILSTIVAQNQ 122 K A AA + G G+R+GA++ N + + + AR R +L TI Q Sbjct: 100 CCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHTMLRTIATMPQ 159 Query: 123 ALGVGRGLVPASGMLNRALERAERRTMHDATVILISDFDGADAATRRMIGAIARHNNVVA 182 A RG + + AL R ERR ++ISDF G R + ARH V+A Sbjct: 160 APAGVRGDLAVA---IDALRRPERRR---GMAVIISDFLGPINWMRPLRAIAARH-EVLA 212 Query: 183 VLVHDPLQSDLPASSRMTVTDGE 205 + V DP +LP + + D E Sbjct: 213 IEVLDPRDVELPDVGDVVLQDAE 235 >ML1809 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) Mle Mycobacterium leprae Length = 320 Score = 85.1 bits (209), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 81/248 (32%), Positives = 116/248 (46%), Gaps = 10/248 (4%) Query: 3 GRGLNFEEIRDYRPGDDVREIDWKVTARLQKPHVRVFNEERDRQALLVVDQRLSMFFGSR 62 G G E R Y+PGDDVR +DW VTAR PHVR +R+ + +V+D S+ FG+ Sbjct: 57 GPGSEPGESRVYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWMVIDMSASLDFGTT 116 Query: 63 RAMKSVTAAETAAIGAWRVLGVGDRVGAIVFNDSDVVELAARRSRATVLQILSTIVAQNQ 122 K A AA + G G+R+GA++ N + + + AR R +L TI + Sbjct: 117 ICEKRDLAVAAAAAITFLNSGGGNRLGALICNGARMTRVPARSGRQHEQTLLRTIATTPK 176 Query: 123 A-LGVGRGLVPASGMLNRALERAERRTMHDATVILISDFDGADAATRRMIGAIARHNNVV 181 A +GV L A AL R ERR ++ISDF G R + ARH V+ Sbjct: 177 APVGVRGDLTVAID----ALRRPERRR---GMAVIISDFLGPINWMRPLRAIAARH-EVL 228 Query: 182 AVLVHDPLQSDLPASSRMTVTDGELQIQLEVGRE-SVRKSIAQASQERLRGVFAWTRELG 240 + V DP LP + + D E + E + ++R A+A+ V R G Sbjct: 229 GIEVLDPRDVALPDIGEVVLQDAETGVTREFTIDAALRDDFARAAAAHCADVSRSLRNCG 288 Query: 241 IPVLPLST 248 P++ L T Sbjct: 289 APLMSLRT 296