BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0032.0003.p (247 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0202 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Rso ... 135 7e-32 MK1667 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Mka M... 104 2e-22 PH1923 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Pho P... 97 4e-20 AF1419 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Afu A... 96 7e-20 PAB1114 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Pab ... 92 8e-19 >RSc0202 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Rso Ralstonia solanacearum Length = 320 Score = 135 bits (341), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 83/207 (40%), Positives = 115/207 (55%), Gaps = 5/207 (2%) Query: 32 LHRFPDGELRVTVG-PAAPTTI-ICCSLNDPNEKLIALLFAAEALRRGGARRLVLVAPYL 89 + RFPDGE V + P + I C+L+ P+EK++ LL+ A A +GGARR+ LVAPYL Sbjct: 45 MKRFPDGEFHVRLQTPVCDAEVAIVCTLDRPDEKVLPLLWLAIAAHQGGARRVGLVAPYL 104 Query: 90 GYMRQDAAFYAGEAISQRAIGDLFAKTVDRVITVEAHLHRTATLNHVFPGIETDNLTAAS 149 YMRQDA F +GE + R +L + D ++ V+ HLHR L+ ++ G+ AA Sbjct: 105 AYMRQDAIFQSGEICAARHFAELLTRYFDWLVAVDPHLHRIPELSDIY-GMPVTVAQAAP 163 Query: 150 VIESMLRADTLDPTTLVVGPDTESRPWVSDLAGRLGLAFAVGEKIRRGDRSVQIVFSDPA 209 + + +RA DP L +GPD ESR WV +AG + V K R V + Sbjct: 164 AMAAWVRAHVSDP--LFIGPDDESRQWVEHVAGLCSAPWTVLSKTRYSAWDVAVSAIGSN 221 Query: 210 PLLQRPVVLVDDIVSSGGTLIGCAEAL 236 P Q VL+DDI+S+G TLI A L Sbjct: 222 PRSQHTPVLIDDIISTGRTLIAAAHQL 248 >MK1667 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Mka Methanopyrus kandleri AV19 Length = 291 Score = 104 bits (260), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 73/226 (32%), Positives = 111/226 (49%), Gaps = 7/226 (3%) Query: 13 VAIGRQLAERLGVPGHEIVLHRFPDGELRVTVGPAAPTTIICCSLNDP--NEKLIALLFA 70 V +GR+LAE L + RFPDGE V V P T++ P +E L+ + Sbjct: 10 VKLGRRLAEELDAELAPVEEDRFPDGEQIVRVPPELDGTVVVVHSMSPPQDENLVKAIIT 69 Query: 71 AEALRRGGARRLVLVAPYLGYMRQDAAFYAGEAISQRAIGDLFAKTVDRVITVEAHLHRT 130 +A R GA ++ + PY+ Y RQD F GE +S RA+ + D +ITV+ LH Sbjct: 70 LDAARENGAEEVIAIVPYMAYSRQDRRFEPGEPVSFRAVARAVSANADALITVD--LHEP 127 Query: 131 ATLNHVFPGIETDNLTAASVIESMLRADTLDPTTLVVGPDTESRPWVSDLAGRLGLAFAV 190 TL + + +N++AA + L +V+GPD +R ++A G+ + Sbjct: 128 GTLKYF--DVPAENVSAAEELGKYLAERFEGEDLVVIGPDEGARELAREVASICGVEYDH 185 Query: 191 GEKIRRGDRSVQIVFSDPAPLLQRPVVLVDDIVSSGGTLIGCAEAL 236 EK R V+I + R VVLVDD++ +GGT++ A AL Sbjct: 186 LEKKRLSGDEVEI-HPKELDVEGRTVVLVDDMIDTGGTMVEAARAL 230 >PH1923 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Pho Pyrococcus horikoshii Length = 287 Score = 97.1 bits (240), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 104/206 (50%), Gaps = 8/206 (3%) Query: 32 LHRFPDGELRVTVGPAAPTTIICCSLNDP-NEKLIALLFAAEALRRGGARRLVLVAPYLG 90 + +FPDGE V + I+ S P +E LI + +AL+ G +L LV PYL Sbjct: 29 IKKFPDGEKYVRILEHGEEVIVVQSTYRPQDEHLIETIIIGDALKEAGFEKLKLVVPYLA 88 Query: 91 YMRQDAAFYAGEAISQRAIGDLFAKTVDRVITVEAHLHRTATLNHVFPGIETDNLTAASV 150 Y RQD GE IS RAI + D + + +H TL+ FPG + N+ A V Sbjct: 89 YSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFD--IHNPKTLD-FFPG-KAVNIYPAKV 144 Query: 151 IESMLRADTLDPTTLVVGPDTESRPWVSDLAGRLGLAFAVGEKIRRGDRSVQIVFSDPAP 210 I R D L+ LV+ PD + ++A LGL ++ EK R V++ D Sbjct: 145 IAEYFR-DKLE-NGLVLAPDRGALERAKEVANILGLEYSHFEKERISPTEVKMTPVD-VN 201 Query: 211 LLQRPVVLVDDIVSSGGTLIGCAEAL 236 + R V++VDDI+S+GGT+I AE L Sbjct: 202 VKGRNVLIVDDIISTGGTMIRAAEIL 227 >AF1419 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Afu Archaeoglobus fulgidus Length = 271 Score = 95.9 bits (237), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 74/227 (32%), Positives = 112/227 (49%), Gaps = 18/227 (7%) Query: 10 PTSVAIGRQLAERLGVPGHEIVLHRFPDGELRVTVGPAAPTTIICCSLNDPNEKLIALLF 69 P+S + R++AE G+ V +FPDGEL V V ++ S+N NE LIAL+F Sbjct: 7 PSSPLLARRVAEAAGIEIGGAVFKKFPDGELYVRV--MEKEGVVVGSIN-SNEDLIALIF 63 Query: 70 AAEALRRGGARRLVLVAPYLGYMRQDAAFYAGEAISQRAIGDLFAKTVDRVITVEAHLHR 129 A + L A V PY+GY RQD F GEA+S + + ++ D V+TV ++H Sbjct: 64 ALDVLENAKA-----VVPYMGYARQDKVFQEGEAVSIKIVAEMLESRADEVVTV--NIHS 116 Query: 130 TATLNHVFPGIETDNLTAASVIESMLRADTLDPTTLVVGPDTESRPWVSDLAGRLGLAFA 189 + +H F ++ NL A ++ + +++ PD S V A G + Sbjct: 117 SDAASH-FSKLK--NLDAMPLVGEYFAGKDV----VMISPDKGSMERVKTAAKHAGCEWD 169 Query: 190 VGEKIRRGDRSVQIVFSDPAPLLQRPVVLVDDIVSSGGTLIGCAEAL 236 EK RR D + + + R VV+VDDI+S+GGT+ A L Sbjct: 170 YMEK-RRIDATTVEITPKTIDVEGRDVVIVDDIISTGGTVAEAARIL 215 >PAB1114 [FE] COG0462 Phosphoribosylpyrophosphate synthetase Pab Pyrococcus abyssi Length = 282 Score = 92.4 bits (228), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 74/223 (33%), Positives = 108/223 (48%), Gaps = 10/223 (4%) Query: 17 RQLAERLGVPGH--EIVLHRFPDGELRVTVGPAAPTTIICCSLNDP-NEKLIALLFAAEA 73 + L E + G+ + + +FPDGE V V I+ S P +E LI L +A Sbjct: 9 KHLEEEISRHGNLINVEIKKFPDGEKYVRVLERGKEAIVIQSTYHPQDENLIEALLLGDA 68 Query: 74 LRRGGARRLVLVAPYLGYMRQDAAFYAGEAISQRAIGDLFAKTVDRVITVEAHLHRTATL 133 L G ++L +V PYL Y RQD GE IS RAI + D + + +H TL Sbjct: 69 LSEAGFKKLKIVIPYLAYSRQDRVTKEGEPISVRAIMKMLGLYYDELYVFD--IHNPKTL 126 Query: 134 NHVFPGIETDNLTAASVIESMLRADTLDPTTLVVGPDTESRPWVSDLAGRLGLAFAVGEK 193 H FPGI N+ A I + + D L L++ PD + +A LGL ++ EK Sbjct: 127 EH-FPGI-AKNIYPAEAIANYFK-DKLG-EGLILAPDKGALERAKRVAEVLGLEYSHFEK 182 Query: 194 IRRGDRSVQIVFSDPAPLLQRPVVLVDDIVSSGGTLIGCAEAL 236 R V++ D + + V++VDDI+S+GGT+I A L Sbjct: 183 ERISPTEVRMKPVD-VDVNGKNVLIVDDIISTGGTMIKAANIL 224