BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0030.0026.p (679 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SMb20088_2 [R] COG2312 Erythromycin esterase homolog Sme Sinorhi... 474 e-133 MT2089_2 [R] COG2312 Erythromycin esterase homolog MtC Mycobacte... 310 5e-84 Rv2030c_2 [R] COG2312 Erythromycin esterase homolog Mtu Mycobact... 310 9e-84 SMb20088_1 [O] COG2518 Protein-L-isoaspartate carboxylmethyltran... 232 2e-60 MTH827 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransfer... 207 7e-53 >SMb20088_2 [R] COG2312 Erythromycin esterase homolog Sme Sinorhizobium meliloti Length = 445 Score = 474 bits (1221), Expect = e-133, Method: Compositional matrix adjust. Identities = 249/451 (55%), Positives = 304/451 (67%), Gaps = 9/451 (1%) Query: 232 NDSRMPGRA-PRPISSQREMLVRNLADAAEPFASIEAADLDPLMERIGPARVVLLGEATH 290 ++ R RA PRP + E++ A+AAEP ++ L +R R+VLLGEA+H Sbjct: 1 HEERAQSRARPRPAPTLPELV----AEAAEPLPDLDDPAFGLLFDRFAGRRIVLLGEASH 56 Query: 291 GTSEFYGMRARITRDLIVKKGFRFVAIEADWPDAARVDHYVRHFQYPPSEWTAFARFPTW 350 GTSEFY RA ITR LI + GF VA+EADWPDAA VD YVRH + F RFPTW Sbjct: 57 GTSEFYRARAAITRRLIEEHGFAIVAVEADWPDAAAVDRYVRHRRQGIRLDAPFQRFPTW 116 Query: 351 MWRNAEMRDFVSWLRKHNGGVERNKRAACHGLDLYSLYDSIRCVLNYLDQVDPKSARVAR 410 MWRN E+ DFV W+R+HNG RA +GLD+Y++ SI VL YLD+ DP++A VAR Sbjct: 117 MWRNREVMDFVEWMREHNGRRSLPDRAGFYGLDIYNMRGSISAVLRYLDETDPEAAAVAR 176 Query: 411 ERYGCLTPWQRDPATYGHAALTGSYPTCESHVVRALTDLLEKRRTYAEHDGDRFLDAEQN 470 ERYGCLTPWQ +P+TYG AA+T + CE VVR +LLEK+ GD LDA QN Sbjct: 177 ERYGCLTPWQNEPSTYGRAAMTAGFRKCEEAVVRQCRELLEKQLEAGRDSGDELLDAVQN 236 Query: 471 ARLVASAERYYRIMYYGSRASWNLRDNHMFETLKNLLAYHGPDSKAVVWAHNSHVGNAGA 530 ARLVASAERYYRIMYY SWN+RD HMFETL++LL G SKAVVWAHNSH+G+A Sbjct: 237 ARLVASAERYYRIMYYAGADSWNMRDTHMFETLEHLLNARGARSKAVVWAHNSHIGDARH 296 Query: 531 TEMA-ARGEYNLGQLCRSEFGDGAYMVGFGTHSGTVAAASEWDGPMEIKAVRPSHPESYE 589 T+M AR E N+GQLCR FGD A ++GFGTH G VAAAS+W+G ME+K +RPS SYE Sbjct: 297 TDMGMAREELNIGQLCRERFGDQAALIGFGTHGGHVAAASDWNGDMEVKPIRPSLEGSYE 356 Query: 590 RLCHATGLPRFMLAMRERGDLCGSGGLGKERLERAVGVIYRPDTELGSHYFRAVLPQQFD 649 R+ H +G+ F++ L GL K LER +GVIYRPDTE SHY A LP+QFD Sbjct: 357 RVMHDSGVGCFLIDFARHARL--RDGLLKPLLERFIGVIYRPDTERFSHYAHASLPRQFD 414 Query: 650 EYVWFDDSCAVTPLETAEIK-GLPDTYPFGV 679 +VWFD + V PL IK G+PDT+PFG+ Sbjct: 415 GFVWFDQTTPVEPLGAQHIKAGVPDTFPFGL 445 >MT2089_2 [R] COG2312 Erythromycin esterase homolog MtC Mycobacterium tuberculosis CDC1551 Length = 459 Score = 310 bits (795), Expect = 5e-84, Method: Compositional matrix adjust. Identities = 196/425 (46%), Positives = 249/425 (58%), Gaps = 21/425 (4%) Query: 273 LMERIGPARVVLLGEATHGTSEFYGMRARITRDLIVKKGFRFVAIEADWPDAARVDHYVR 332 L E +G AR+VL+GE++HGT EFY RA +T+ LI +KGF VA EADWPDA RV+ YVR Sbjct: 38 LAELVGDARIVLIGESSHGTHEFYQARAAMTQWLIEEKGFGAVAAEADWPDAYRVNRYVR 97 Query: 333 HF---QYPPSEWTAFARFPTWMWRNAEMRDFVSWLRKHNGGVERN--KRAACHGLDLYSL 387 + F RFP WMWRN +RDFV WLR N E ++A +GLDLYSL Sbjct: 98 GLGEDTNADEALSGFERFPAWMWRNTVVRDFVEWLRTRNQRYESGALRQAGFYGLDLYSL 157 Query: 388 YDSIRCVLNYLDQVDPKSARVARERYGCLT-PWQRDPATYGHAALTGSYPTCESHVVRAL 446 + SI+ V++YLD+VDP++A AR RY C D YG AA G+ P+CE V L Sbjct: 158 HRSIQEVISYLDKVDPRAAARARARYACFDHACADDGQAYGFAAAFGAGPSCEREAVEQL 217 Query: 447 TDLLEKRRTYAEHDG----DRFLDAEQNARLVASAERYYRIMYYGSRASWNLRDNHMFET 502 D+ YA DG D A+QNA+ V AE YYR M+ G SWNLRD HM +T Sbjct: 218 VDVQRNALAYARQDGLLAEDELFYAQQNAQTVRDAEVYYRAMFSGRVTSWNLRDQHMAQT 277 Query: 503 LKNLLAY-----HGPDSKAVVWAHNSHVGNAGATEMAARGEYNLGQLCRSEFGDGAYMVG 557 L +LL + P ++ VVWAHNSHVG+A ATE+ A G+ LGQ+ R +GD + +G Sbjct: 278 LGSLLTHLDRHLDAPPARIVVWAHNSHVGDARATEVWADGQLTLGQIVRERYGDESRSIG 337 Query: 558 FGTHSGTVAAASEWDGPMEIKAVRPSHPESYERLCHATGLPRFMLAMRERGDLCGSGGLG 617 F T++GTV AASEW G + KAVRP+ S E L H T F+++ R D L Sbjct: 338 FSTYTGTVTAASEWGGIAQRKAVRPALHGSVEELFHQTA-DSFLVSARLSRD--AEAPLD 394 Query: 618 KERLERAVGVIYRPDTELGSHYFRAVLPQQFDEYVWFDDSCAVTPLETAE--IKGL-PDT 674 RL RA+GV+Y P TE SHY QFD + D + A+ PLE I G P+T Sbjct: 395 VVRLGRAIGVVYLPATERQSHYLHVRPADQFDAMIHIDQTRALEPLEVTSRWIAGENPET 454 Query: 675 YPFGV 679 YP G+ Sbjct: 455 YPTGL 459 >Rv2030c_2 [R] COG2312 Erythromycin esterase homolog Mtu Mycobacterium tuberculosis H37Rv Length = 422 Score = 310 bits (793), Expect = 9e-84, Method: Compositional matrix adjust. Identities = 196/425 (46%), Positives = 249/425 (58%), Gaps = 21/425 (4%) Query: 273 LMERIGPARVVLLGEATHGTSEFYGMRARITRDLIVKKGFRFVAIEADWPDAARVDHYVR 332 L E +G AR+VL+GE++HGT EFY RA +T+ LI +KGF VA EADWPDA RV+ YVR Sbjct: 1 LAELVGDARIVLIGESSHGTHEFYQARAAMTQWLIEEKGFGAVAAEADWPDAYRVNRYVR 60 Query: 333 HF---QYPPSEWTAFARFPTWMWRNAEMRDFVSWLRKHNGGVERN--KRAACHGLDLYSL 387 + F RFP WMWRN +RDFV WLR N E ++A +GLDLYSL Sbjct: 61 GLGEDTNADEALSGFERFPAWMWRNTVVRDFVEWLRTRNQRYESGALRQAGFYGLDLYSL 120 Query: 388 YDSIRCVLNYLDQVDPKSARVARERYGCLT-PWQRDPATYGHAALTGSYPTCESHVVRAL 446 + SI+ V++YLD+VDP++A AR RY C D YG AA G+ P+CE V L Sbjct: 121 HRSIQEVISYLDKVDPRAAARARARYACFDHACADDGQAYGFAAAFGAGPSCEREAVEQL 180 Query: 447 TDLLEKRRTYAEHDG----DRFLDAEQNARLVASAERYYRIMYYGSRASWNLRDNHMFET 502 D+ YA DG D A+QNA+ V AE YYR M+ G SWNLRD HM +T Sbjct: 181 VDVQRNALAYARQDGLLAEDELFYAQQNAQTVRDAEVYYRAMFSGRVTSWNLRDQHMAQT 240 Query: 503 LKNLLAY-----HGPDSKAVVWAHNSHVGNAGATEMAARGEYNLGQLCRSEFGDGAYMVG 557 L +LL + P ++ VVWAHNSHVG+A ATE+ A G+ LGQ+ R +GD + +G Sbjct: 241 LGSLLTHLDRHLDAPPARIVVWAHNSHVGDARATEVWADGQLTLGQIVRERYGDESRSIG 300 Query: 558 FGTHSGTVAAASEWDGPMEIKAVRPSHPESYERLCHATGLPRFMLAMRERGDLCGSGGLG 617 F T++GTV AASEW G + KAVRP+ S E L H T F+++ R D L Sbjct: 301 FSTYTGTVTAASEWGGIAQRKAVRPALHGSVEELFHQTA-DSFLVSARLSRD--AEAPLD 357 Query: 618 KERLERAVGVIYRPDTELGSHYFRAVLPQQFDEYVWFDDSCAVTPLETAE--IKGL-PDT 674 RL RA+GV+Y P TE SHY QFD + D + A+ PLE I G P+T Sbjct: 358 VVRLGRAIGVVYLPATERQSHYLHVRPADQFDAMIHIDQTRALEPLEVTSRWIAGENPET 417 Query: 675 YPFGV 679 YP G+ Sbjct: 418 YPTGL 422 >SMb20088_1 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase Sme Sinorhizobium meliloti Length = 213 Score = 232 bits (592), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 120/211 (56%), Positives = 150/211 (71%), Gaps = 1/211 (0%) Query: 17 FPSLRKAMVERDIAARGVRDEFVLEAMRKVPRELFLPKNLHEFAYEDAPLPIAGDQTISQ 76 F R+ M+ ++ RG+RD V+EAM VPRE F+ EFAYED+ L I+ QTISQ Sbjct: 4 FSRARERMITSHLSRRGIRDRHVVEAMGVVPREAFVDPGFEEFAYEDSALSISHGQTISQ 63 Query: 77 PYIVAFMVEALMLKGGEKVLEIGAGSGYAAAVLSEIAANVYTVERLGPLAETAARTLADL 136 PYIVA M+E ++ G+ VLEIG GSGYAAAVLS IAA VYT+ER LAE A R A+L Sbjct: 64 PYIVALMIERAEVQPGDTVLEIGTGSGYAAAVLSRIAAYVYTIERHAGLAEVAERRFAEL 123 Query: 137 GYDNVHVLHGDGTRGWPDHAPYDAIIVAAGGPQIPESLKEQLKIGGRLVIPVGSDQRSQE 196 Y N+ V GDGT GWP+ P+DAI+VAAGGP+IP +LKEQL +GG LVIPVG + Q Sbjct: 124 RYGNIDVRVGDGTAGWPEAGPFDAILVAAGGPEIPHALKEQLDLGGHLVIPVGPPE-EQR 182 Query: 197 LVRVTRVSANEYRSEDIADVRFVPLIGEEGW 227 L++VTRV+A + +D+ VRFVPL+GE GW Sbjct: 183 LMKVTRVNATTFEEQDLGGVRFVPLVGEYGW 213 >MTH827 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase Mth Methanothermobacter thermautotrophicus Length = 217 Score = 207 bits (527), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 111/211 (52%), Positives = 147/211 (69%), Gaps = 5/211 (2%) Query: 21 RKAMVERDIAARG-VRDEFVLEAMRKVPRELFLPKNLHEFAYEDAPLPIAGDQTISQPYI 79 R+ MV+ D+ RG ++ E V AM +VPRE F+P++ AY D PLPI QTIS P++ Sbjct: 5 RRRMVQ-DLMERGYIKSEAVRRAMERVPREEFVPEDEMHRAYMDMPLPIGEGQTISAPHM 63 Query: 80 VAFMVEALMLKGGEKVLEIGAGSGYAAAVLSEIAA---NVYTVERLGPLAETAARTLADL 136 VA + E L L+ G KVLEIG G GY AAV++EI ++YTVER+G L E A + L L Sbjct: 64 VAMIAEILDLEPGMKVLEIGTGCGYNAAVIAEIIGPEGHLYTVERIGILYERARKKLRSL 123 Query: 137 GYDNVHVLHGDGTRGWPDHAPYDAIIVAAGGPQIPESLKEQLKIGGRLVIPVGSDQRSQE 196 GYDN+ V+HGDG++G+ D APY I V A P IP+ L +QL+IGG+L+IPVGSD+ QE Sbjct: 124 GYDNITVIHGDGSQGFADEAPYSRIYVTAAAPYIPDPLMKQLEIGGKLLIPVGSDKFYQE 183 Query: 197 LVRVTRVSANEYRSEDIADVRFVPLIGEEGW 227 LV + R SA++YRS ++ V FVPLIG+ GW Sbjct: 184 LVLIERTSADDYRSRNLGGVAFVPLIGKHGW 214