BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0024.0008.p (1057 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mlr3285 [V] COG0841 Cation/multidrug efflux pump Mlo Mesorhizobi... 1122 0.0 SMc03971 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizob... 1107 0.0 PA2494 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 1021 0.0 STM0351 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1000 0.0 PA3522 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas ... 978 0.0 >mlr3285 [V] COG0841 Cation/multidrug efflux pump Mlo Mesorhizobium loti Length = 1067 Score = 1122 bits (2903), Expect = 0.0, Method: Compositional matrix adjust. Identities = 570/1056 (53%), Positives = 760/1056 (71%), Gaps = 5/1056 (0%) Query: 1 MNLGRLSINQPILAMVLSIVLLIVGAIAYPTLPVSEYPQVVPPTVVVTTQYPGASAQTVS 60 M +++PI A V+SIVLLI+G IAY LPV++YP++ PPT+VV QYPGA A+TV+ Sbjct: 1 MRFAHFFVDRPIFASVVSIVLLILGGIAYTQLPVAQYPEIAPPTIVVRAQYPGADAETVA 60 Query: 61 DTVAAPIEQEINGVEDMLYLYSQATSNGQLTITATFKLGTDLDKAQVLVQNRVAIAQPRL 120 TVA PIEQEINGVE MLY+ S ++ +G + +T TFKLGTDLDKAQVLVQNRV++A+PRL Sbjct: 61 ATVATPIEQEINGVEGMLYMSSYSSGDGAMALTITFKLGTDLDKAQVLVQNRVSVAEPRL 120 Query: 121 PEEVQRNGVTTRKNSPDILMVVFMLSPDDTFDQLYISNYALLQVRDQLLRLDGVGDIQMF 180 PEEV+R G+TT K+SPD++MVV MLSPD+T+DQLY+SNYA +VRD LLRLDGVGD+ +F Sbjct: 121 PEEVRRLGITTTKSSPDLMMVVHMLSPDNTYDQLYVSNYARSRVRDILLRLDGVGDLIIF 180 Query: 181 GARDYSMRLWLDPDRIANLGLTSTEVLAAIRAQNLQIAGGQIAEPPI-ADRAFQPNLVFT 239 G R+YS+R+WLDP++++ LG+TS +V+ A+R QN+Q++GG I PP AFQ + Sbjct: 181 GEREYSLRIWLDPEKLSALGMTSGDVVQALRDQNVQVSGGSIGAPPTNTGTAFQYTVTTQ 240 Query: 240 GRLKDIRQFEDIVVKAGSDGRTVRLRDVARVELGALSYATNSFLLRKSAVALLVTQRPGS 299 GR D R F ++VK+ DGR + L+DVAR+ELGA Y TNS+L K AVAL + QRPG+ Sbjct: 241 GRFNDARDFRYVIVKSTDDGRLISLQDVARIELGAKDYVTNSYLNGKPAVALAIFQRPGT 300 Query: 300 NALATAKSISDTMERMKASFPKGLDYNIGYNPTEFIAQSVHELIKTIYEAMALVVIVVLV 359 NALA A I D M+ + FPKGL Y+I YNPTEF+A+S+ E+ KTI EAM LV+IV++V Sbjct: 301 NALAAAAEIQDKMKELSRDFPKGLSYDIVYNPTEFVAESIQEVYKTILEAMLLVIIVIIV 360 Query: 360 FLQGWRPAIIPIIAIPVSLVGTFAVMAALGFSINNLTLFGLVLAVGIVVDDAIVVVENVE 419 FLQ WR AI+PI+AIPVSL+GT AV+ A GFS+N LTLFGLVLA+GIVVDDAIVVVENVE Sbjct: 361 FLQSWRMAIVPIVAIPVSLIGTLAVLYAAGFSLNMLTLFGLVLAIGIVVDDAIVVVENVE 420 Query: 420 RHLEHGMSRRDAALKTMEEVGGALVSIALVLCAVFVPTAFLGGISGQFFQQFAVTIAVAT 479 R++ G++ A+ TM EVG A+++I+LVL AVFVPTAF+ GISGQF+ QFA+TIAV+T Sbjct: 421 RNIASGLAPNPASHLTMNEVGTAIIAISLVLIAVFVPTAFVPGISGQFYLQFAITIAVST 480 Query: 480 AISCFCSLTLSPALASQILVPHEEKRPPARWNIIARGWDSFTALFNRVFDRLAHGYASVA 539 AIS F SLTLSPALA+ + PH P R+ +AR + FNR FDR+AH Y+S+ Sbjct: 481 AISAFNSLTLSPALAALLFKPHHAAAAPPRF-FLARFGRALADGFNRGFDRVAHWYSSII 539 Query: 540 DFVIRHTVV---MLALYLVLIGSAGWLLATTSQGFIPAQDRGYVIISAQLPGAASLARTT 596 ++ + MLA++ LI + +++ +GFIP+ D+GY I+ QLP A+L+RT Sbjct: 540 RVLVGSRIAIAAMLAVFAALIYATVYMVQAVPRGFIPSLDQGYAIVVVQLPDGAALSRTD 599 Query: 597 AVVREIERIALDTPGIVRVAAFAGFSGATRTQQGNAAALFPVFDEPEARLKKGLTANAIT 656 AV+++ +I TPG+ AFAGFSGAT T N +F F + RLK G +A + Sbjct: 600 AVIQQASQIIQKTPGVDYAVAFAGFSGATFTNASNQGVIFARFKPFDERLKAGQSATQVI 659 Query: 657 AELRKRLSVIQGAFIIVIPPPAVPGIGTGGGFTIRVQDRQGRGPELLASATDELVTAARK 716 L L I+ AFII +PPP + G+G GGF +++Q+R + + E+ A K Sbjct: 660 GNLFGSLQSIKEAFIIALPPPPIRGVGNAGGFKLQIQERNSADMRQILALAYEIAGKANK 719 Query: 717 SPSLTSVFSPFTANTPQLFVDIDRVKAQKLGVPIANINDTIQTYFGSTYVNDFNLFGRTY 776 +P LT VF+ F+A++PQ F+ IDR KA+ L VPI NI +T+ G+ YVNDFN FGR Y Sbjct: 720 TPGLTGVFTTFSASSPQFFLAIDRDKARILNVPIPNIFETLSINLGTAYVNDFNAFGRVY 779 Query: 777 HVTAQADLPFRKDSPDLARLRTRNVAGDMVMLGSIVDFKDVSGPDRVARYNLYSASELQG 836 V AQAD FR D D+ +L+ R+ G +V LG++++ +DV+GP V RYN+Y + LQG Sbjct: 780 QVRAQADQAFRLDRADILKLKVRSATGALVPLGTLIEIRDVTGPALVQRYNMYVSVPLQG 839 Query: 837 EPAPGVSSTTALNTIKQLADQTLPSGFSFEWTDLSYQQVTGANAGLYVFPICVLFVYLVL 896 APGVS+ AL ++ + +TLP+G S+EWT+L+YQ+ NA +Y+F + VLFV+L L Sbjct: 840 NAAPGVSTGDALALMEGITAKTLPAGTSYEWTELAYQEHNTGNAAVYIFGLSVLFVFLAL 899 Query: 897 AAQYGSWTLPFAVILIVPMCLFAATIGVRIMGQDVNILTQIGFVVLVGLAAKNAILIVEF 956 AAQY SW LPFA++L+VP+ + AA +GV G D NIL QIG +VL+GLAAKNAILIVEF Sbjct: 900 AAQYESWVLPFAIVLVVPLGVLAALLGVSFRGLDNNILVQIGLIVLIGLAAKNAILIVEF 959 Query: 957 ARDIELEGRSRLDAVIEACRLRLRPILMTSFAFILGVLPLVVSTGSGSEMRQAVGVAVFF 1016 AR + G S +A +EACRLRLRPILMT+F+FILGV+PL+++TG G+EMRQ++G AVF Sbjct: 960 ARQAQERGLSAAEAAVEACRLRLRPILMTAFSFILGVVPLMIATGPGAEMRQSLGTAVFS 1019 Query: 1017 GMLGVTLFGLVFTPIFYMVVRNLAEGKNEGKPAEPK 1052 GMLGVT GL TP+FY+ +R+L + AEP Sbjct: 1020 GMLGVTFVGLFLTPVFYVALRSLFSRRKPRAEAEPS 1055 >SMc03971 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1058 Score = 1107 bits (2864), Expect = 0.0, Method: Compositional matrix adjust. Identities = 571/1043 (54%), Positives = 761/1043 (72%), Gaps = 5/1043 (0%) Query: 1 MNLGRLSINQPILAMVLSIVLLIVGAIAYPTLPVSEYPQVVPPTVVVTTQYPGASAQTVS 60 M +++PI A VLSIVLLIVG+IAY LPV++YP++ PPT+VV YPGA A+TV+ Sbjct: 1 MRFAHFFVDRPIFASVLSIVLLIVGSIAYFQLPVAQYPEIAPPTIVVRASYPGADAETVA 60 Query: 61 DTVAAPIEQEINGVEDMLYLYSQATSNGQLTITATFKLGTDLDKAQVLVQNRVAIAQPRL 120 +TVA P+EQEINGVE+MLY+ S AT++G + +T TFKLGTDLD+AQVLVQNRV+IA+PRL Sbjct: 61 NTVATPLEQEINGVENMLYMSSYATADGSMALTITFKLGTDLDQAQVLVQNRVSIAEPRL 120 Query: 121 PEEVQRNGVTTRKNSPDILMVVFMLSPDDTFDQLYISNYALLQVRDQLLRLDGVGDIQMF 180 PEEV+R GVTT K+SPD++MVV +LSP+D +DQLY+SNYA ++RD L+RLDGVGD+ +F Sbjct: 121 PEEVRRIGVTTTKSSPDLMMVVHLLSPNDRYDQLYVSNYARTRIRDILVRLDGVGDVLLF 180 Query: 181 GARDYSMRLWLDPDRIANLGLTSTEVLAAIRAQNLQIAGGQIAEPPIA-DRAFQPNLVFT 239 G R+Y++R+WLDP +++ G+T+ +V++A+R QN+Q++GG I PP++ D AFQ + Sbjct: 181 GEREYALRIWLDPQKLSAYGMTAGDVVSALREQNVQVSGGSIGGPPMSSDSAFQYTVTTD 240 Query: 240 GRLKDIRQFEDIVVKAGSDGRTVRLRDVARVELGALSYATNSFLLRKSAVALLVTQRPGS 299 GR D RQF ++VKA +GR V+L+DVAR+ELGA Y TNS+L AVAL + RPGS Sbjct: 241 GRFSDARQFRYVIVKATEEGRLVQLQDVARIELGAREYVTNSYLNGSPAVALGIFSRPGS 300 Query: 300 NALATAKSISDTMERMKASFPKGLDYNIGYNPTEFIAQSVHELIKTIYEAMALVVIVVLV 359 NALA A +I TM + FP+GL+Y I YNPTEFI++S+ E+ KTI EA LV +VV+V Sbjct: 301 NALAAADAIQATMTELSRDFPEGLEYRIIYNPTEFISESIDEVYKTIAEAALLVALVVIV 360 Query: 360 FLQGWRPAIIPIIAIPVSLVGTFAVMAALGFSINNLTLFGLVLAVGIVVDDAIVVVENVE 419 FLQ WR AIIPI+AIPVSLVGTFA++ A GFS+N LTLFGLVLA+GIVVDDAIVVVENVE Sbjct: 361 FLQSWRTAIIPIVAIPVSLVGTFALLYAFGFSLNMLTLFGLVLAIGIVVDDAIVVVENVE 420 Query: 420 RHLEHGMSRRDAALKTMEEVGGALVSIALVLCAVFVPTAFLGGISGQFFQQFAVTIAVAT 479 R+L GM+ R+AA TM+EVG A+++I+LVL AVFVPTAF+ GI+GQF+ QFAVTIAVAT Sbjct: 421 RNLARGMTPREAAHVTMDEVGAAVIAISLVLTAVFVPTAFIPGIAGQFYLQFAVTIAVAT 480 Query: 480 AISCFCSLTLSPALASQILVPHEEKRPPARWNIIARGWDSFTALFNRVFDRLAHGYASVA 539 IS SLTLSPALA+ +L PHE +R N + R F FNR FDR+A GYA Sbjct: 481 VISAVNSLTLSPALAAILLRPHENHDHESR-NPLTRLGRGFANGFNRGFDRMADGYAWTV 539 Query: 540 DFVIRHTVVM---LALYLVLIGSAGWLLATTSQGFIPAQDRGYVIISAQLPGAASLARTT 596 ++R + + L +++ L+G+ ++ +GFIP D+GY I+ QLP ASL RT Sbjct: 540 RHLVRTRIALAGALLVFVALLGATWYMAQVVPRGFIPTMDQGYAIVVIQLPDGASLERTD 599 Query: 597 AVVREIERIALDTPGIVRVAAFAGFSGATRTQQGNAAALFPVFDEPEARLKKGLTANAIT 656 VVR + + PG+ AFAGF+GAT T N+ +F FD E RL++ +A I Sbjct: 600 KVVRRASEMIREVPGVKDAVAFAGFNGATFTNASNSGVIFTPFDSFEERLEQKQSAEQII 659 Query: 657 AELRKRLSVIQGAFIIVIPPPAVPGIGTGGGFTIRVQDRQGRGPELLASATDELVTAARK 716 ++ + IQ AFII +PPP+V GIG GGF +++ DRQ +++ AA + Sbjct: 660 GQIFGAMQGIQEAFIIAVPPPSVRGIGNSGGFKMQIMDRQSADMRRALGLAYQMMGAANQ 719 Query: 717 SPSLTSVFSPFTANTPQLFVDIDRVKAQKLGVPIANINDTIQTYFGSTYVNDFNLFGRTY 776 + LT VF+ FTA++PQ F+ IDR KA+ L VPI NI +T+ G++YVNDFN FGR Y Sbjct: 720 TEGLTGVFTTFTASSPQFFLAIDRDKARALNVPIPNIFETLSINLGTSYVNDFNAFGRVY 779 Query: 777 HVTAQADLPFRKDSPDLARLRTRNVAGDMVMLGSIVDFKDVSGPDRVARYNLYSASELQG 836 V AQAD FR + D+ L+ R+ +G +V LG++V+ +D SGP V RYN+Y + +QG Sbjct: 780 QVRAQADQQFRLEREDILALKVRSASGALVPLGTLVEIRDTSGPALVQRYNMYVSVPVQG 839 Query: 837 EPAPGVSSTTALNTIKQLADQTLPSGFSFEWTDLSYQQVTGANAGLYVFPICVLFVYLVL 896 PAPGVS+ +AL+ ++ LA Q LP G +FEWT+L+ Q+ N +++F + V+FV+L L Sbjct: 840 NPAPGVSTGSALDKMEALAGQILPQGTTFEWTELALQERQTGNTAVFIFALSVVFVFLAL 899 Query: 897 AAQYGSWTLPFAVILIVPMCLFAATIGVRIMGQDVNILTQIGFVVLVGLAAKNAILIVEF 956 +AQY SW LP A+ILIVP+ + AA +GV I G D N+LTQIG +VL+GLAAKNAILIVEF Sbjct: 900 SAQYESWVLPLAIILIVPLAVLAALLGVSIRGFDNNVLTQIGLIVLIGLAAKNAILIVEF 959 Query: 957 ARDIELEGRSRLDAVIEACRLRLRPILMTSFAFILGVLPLVVSTGSGSEMRQAVGVAVFF 1016 AR E EG++ ++A I+A RLRLRPILMT+FAFILGV+PLV++TG G+EMRQ++G AVF Sbjct: 960 ARQGEEEGKTPIEAAIDASRLRLRPILMTAFAFILGVVPLVIATGPGAEMRQSLGTAVFA 1019 Query: 1017 GMLGVTLFGLVFTPIFYMVVRNL 1039 GMLGVT GL TP+FY+ +R+L Sbjct: 1020 GMLGVTFLGLFLTPVFYVALRSL 1042 >PA2494 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1062 Score = 1021 bits (2641), Expect = 0.0, Method: Compositional matrix adjust. Identities = 549/1060 (51%), Positives = 743/1060 (70%), Gaps = 11/1060 (1%) Query: 1 MNLGRLSINQPILAMVLSIVLLIVGAIAYPTLPVSEYPQVVPPTVVVTTQYPGASAQTVS 60 MN + I +PI A VLS+++LI GAI+ LP+SEYP+VVPPTVVV +PGA+ + + Sbjct: 1 MNFSQFFIQRPIFAAVLSLLILIGGAISLFQLPISEYPEVVPPTVVVRANFPGANPKVIG 60 Query: 61 DTVAAPIEQEINGVEDMLYLYSQATSNGQLTITATFKLGTDLDKAQVLVQNRVAIAQPRL 120 +TVA+P+EQ I GVE+MLY+ SQ+TS+G+LT+T TF LGTDLD AQV VQNRV +P+L Sbjct: 61 ETVASPLEQAITGVENMLYMSSQSTSDGKLTLTITFALGTDLDNAQVQVQNRVTRTEPKL 120 Query: 121 PEEVQRNGVTTRKNSPDILMVVFMLSPDDTFDQLYISNYALLQVRDQLLRLDGVGDIQMF 180 PEEV R G+T K SPD+ MVV + SPD+ +D LY+SNYA+L V+D+L RLDGVGD+Q+F Sbjct: 121 PEEVTRLGITVDKASPDLTMVVHLTSPDNRYDMLYLSNYAVLNVKDELARLDGVGDVQLF 180 Query: 181 GARDYSMRLWLDPDRIANLGLTSTEVLAAIRAQNLQIAGGQIAEPPI-ADRAFQPNLVFT 239 G DYS+R+WLDP+++A+ LT+T+V+ AIR QN Q+A G + PP +D +FQ ++ Sbjct: 181 GLGDYSLRVWLDPNKVASRNLTATDVVNAIREQNRQVAAGTLGAPPAPSDTSFQLSINTQ 240 Query: 240 GRLKDIRQFEDIVVKAGSDGRTVRLRDVARVELGALSYATNSFLLRKSAVALLVTQRPGS 299 GRL +FE+I+++AG++G RLRD+ARVELG+ YA S L K AVA+ + QRPGS Sbjct: 241 GRLVTEEEFENIIIRAGANGEITRLRDIARVELGSNQYALRSLLNNKPAVAIPIFQRPGS 300 Query: 300 NALATAKSISDTMERMKASFPKGLDYNIGYNPTEFIAQSVHELIKTIYEAMALVVIVVLV 359 NA+ + + + M +K SFP+G+DY+I Y+PT F+ S+ ++ T++EA+ LVV+VV++ Sbjct: 301 NAIEISNLVREKMAELKHSFPQGMDYSIVYDPTIFVRGSIEAVVHTLFEALVLVVLVVIL 360 Query: 360 FLQGWRPAIIPIIAIPVSLVGTFAVMAALGFSINNLTLFGLVLAVGIVVDDAIVVVENVE 419 FLQ WR +IIP+ A+PVSL+GTFAVM LGFS+N L+LFGLVLA+GIVVDDAIVVVENVE Sbjct: 361 FLQTWRASIIPLAAVPVSLIGTFAVMHMLGFSLNALSLFGLVLAIGIVVDDAIVVVENVE 420 Query: 420 RHLEHGMSRRDAALKTMEEVGGALVSIALVLCAVFVPTAFLGGISGQFFQQFAVTIAVAT 479 R++ G+ +A + M EV G +++ ALVLCAVF+PTAF+ G++GQF++QFA+TIA++T Sbjct: 421 RNIGLGLKPVEATKRAMREVTGPIIATALVLCAVFIPTAFISGLTGQFYRQFALTIAIST 480 Query: 480 AISCFCSLTLSPALASQILVPHEEKRPPARWNI----IARGWDSFTALFNRVFDRLAHGY 535 IS F SLTLSPALA+ +L H E P R+++ + W FNR FDR +HGY Sbjct: 481 VISAFNSLTLSPALAAVLLKGHHE--PKDRFSVFLDKLLGSW--LFRPFNRFFDRASHGY 536 Query: 536 ASVADFVIRHTVVMLALYLVLIGSAGWLLATTSQGFIPAQDRGYVIISAQLPGAASLART 595 + V+R + + L +Y L+ + ++T GF+P QD+ Y++ AQLP AASL RT Sbjct: 537 VGTVNRVLRGSSIALLVYGGLMVLTYFGFSSTPTGFVPQQDKQYLVAFAQLPDAASLDRT 596 Query: 596 TAVVREIERIALDTPGIVRVAAFAGFSGATRTQQGNAAALFPVFDEPEARLKKGLTANAI 655 AV++++ IAL PG+ AF G S T N+ +F + R +A AI Sbjct: 597 EAVIKQMSEIALAQPGVADSVAFPGLSINGFTNSPNSGIVFTPLKPFDERKDPSQSAGAI 656 Query: 656 TAELRKRLSVIQGAFIIVIPPPAVPGIGTGGGFTIRVQDRQGRGPELLASATDELVTAAR 715 A L + + IQ A+I + PPP V G+GT GGF ++++DR +G E L T ++T AR Sbjct: 657 AAALNAKYADIQDAYIAIFPPPPVQGLGTIGGFRLQIEDRGNQGYEELFKQTQNIITKAR 716 Query: 716 KSPSL--TSVFSPFTANTPQLFVDIDRVKAQKLGVPIANINDTIQTYFGSTYVNDFNLFG 773 P L +SVFS + N PQ+ DIDR KA+ GV I++I DT+Q Y GS Y NDFN FG Sbjct: 717 ALPELEPSSVFSSYQVNVPQIDADIDREKAKTHGVAISDIFDTLQVYLGSLYANDFNRFG 776 Query: 774 RTYHVTAQADLPFRKDSPDLARLRTRNVAGDMVMLGSIVDFKDVSGPDRVARYNLYSASE 833 RTY V QA+ FR + + +L+ RN G+MV L S + D SGPDRV YN + +E Sbjct: 777 RTYQVNVQAEQQFRLEPEQIGQLKVRNNLGEMVPLASFIKVSDTSGPDRVMHYNGFITAE 836 Query: 834 LQGEPAPGVSSTTALNTIKQLADQTLPSGFSFEWTDLSYQQVTGANAGLYVFPICVLFVY 893 L G PA G SS A I++L + LP+G ++EWT+L+YQQ+ N L+VFP+CVL + Sbjct: 837 LNGAPAAGYSSGQAQAAIEKLLKEELPNGMTYEWTELTYQQILAGNTALFVFPLCVLLAF 896 Query: 894 LVLAAQYGSWTLPFAVILIVPMCLFAATIGVRIMGQDVNILTQIGFVVLVGLAAKNAILI 953 LVLAAQY SW+LP AVILIVPM L +A GV + G D NI TQIG +VLVGLA KNAILI Sbjct: 897 LVLAAQYESWSLPLAVILIVPMTLLSAITGVILAGSDNNIFTQIGLIVLVGLACKNAILI 956 Query: 954 VEFARDIELEGRSRLDAVIEACRLRLRPILMTSFAFILGVLPLVVSTGSGSEMRQAVGVA 1013 VEFA+D + EG R+ AV+EACRLRLRPILMTS AFI+GV+PLV+STG+G+EMR A+GVA Sbjct: 957 VEFAKDKQEEGMDRVAAVLEACRLRLRPILMTSIAFIMGVVPLVISTGAGAEMRHAMGVA 1016 Query: 1014 VFFGMLGVTLFGLVFTPIFYMVVRNLAEGKNEGKPAEPKA 1053 VF GM+GVT FGL+ TP+FY+++R E + + A K Sbjct: 1017 VFSGMIGVTFFGLLLTPVFYVLIRRFVENREARRAANDKG 1056 >STM0351 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1055 Score = 1000 bits (2586), Expect = 0.0, Method: Compositional matrix adjust. Identities = 530/1043 (50%), Positives = 718/1043 (68%), Gaps = 5/1043 (0%) Query: 1 MNLGRLSINQPILAMVLSIVLLIVGAIAYPTLPVSEYPQVVPPTVVVTTQYPGASAQTVS 60 M I +PI A+VLS+++L+ GAIA+ LP+SEYP V PPTV V+ YPGA+ Q ++ Sbjct: 1 MKFTHFFIARPIFAIVLSLLMLLAGAIAFLKLPLSEYPAVTPPTVQVSASYPGANPQVIA 60 Query: 61 DTVAAPIEQEINGVEDMLYLYSQATSNGQLTITATFKLGTDLDKAQVLVQNRVAIAQPRL 120 DTVAAP+EQ INGV+ MLY+ +Q +G++ I+ F+ GTD D AQ+ VQNRV+ A PRL Sbjct: 61 DTVAAPLEQVINGVDGMLYMNTQMAIDGRMVISIAFEQGTDPDMAQIQVQNRVSRALPRL 120 Query: 121 PEEVQRNGVTTRKNSPDILMVVFMLSPDDTFDQLYISNYALLQVRDQLLRLDGVGDIQMF 180 PEEVQR GV T K SPD+LMVV ++SP +D LY+SN+A+ QVRD+L RL GVGD+ ++ Sbjct: 121 PEEVQRIGVVTEKTSPDMLMVVHLVSPQKRYDSLYLSNFAIRQVRDELARLPGVGDVLVW 180 Query: 181 GARDYSMRLWLDPDRIANLGLTSTEVLAAIRAQNLQIAGGQIAEPPIADRAFQPNLVFTG 240 GA +Y+MR+WLDP +IAN GLT+++++ A+R QN+Q+A G + + P A AFQ + G Sbjct: 181 GAGEYAMRVWLDPAKIANRGLTASDIVTALREQNVQVAAGSVGQQPEASAAFQMTVNTLG 240 Query: 241 RLKDIRQFEDIVVKAGSDGRTVRLRDVARVELGALSYATNSFLLRKSAVALLVTQRPGSN 300 RL QF +IVVK G+DG RLRDVARV LGA +Y S L ++A AL + Q PG+N Sbjct: 241 RLTSEEQFGEIVVKIGADGEVTRLRDVARVTLGADAYTLRSLLNGEAAPALQIIQSPGAN 300 Query: 301 ALATAKSISDTMERMKASFPKGLDYNIGYNPTEFIAQSVHELIKTIYEAMALVVIVVLVF 360 A+ + +I M+ ++ +FP+ ++Y I Y+PT F+ S+ + T+ EA+ LVV+VV++F Sbjct: 301 AIDVSNAIRGKMDELQQNFPQDIEYRIAYDPTVFVRASLQSVAITLLEALVLVVLVVVMF 360 Query: 361 LQGWRPAIIPIIAIPVSLVGTFAVMAALGFSINNLTLFGLVLAVGIVVDDAIVVVENVER 420 LQ WR +IIP++A+PVSLVGTFA+M GFS+N L+LFGLVL++GIVVDDAIVVVENVER Sbjct: 361 LQTWRASIIPLVAVPVSLVGTFALMHLFGFSLNTLSLFGLVLSIGIVVDDAIVVVENVER 420 Query: 421 HLEHGMSRRDAALKTMEEVGGALVSIALVLCAVFVPTAFLGGISGQFFQQFAVTIAVATA 480 H+ G S +AA K M+EV G ++SI VL AVF+P+AFL G+ G+F++QFA+TIA++T Sbjct: 421 HISQGKSPGEAAKKAMDEVTGPILSITSVLTAVFIPSAFLAGLQGEFYRQFALTIAISTI 480 Query: 481 ISCFCSLTLSPALASQILVPHEEKRPPARW--NIIARGWDSFTALFNRVFDRLAHGYASV 538 +S SLTLSPALA+ +L PH + A W ++ F FNR FD ++ Y S Sbjct: 481 LSAINSLTLSPALAAILLRPHHDT-AKADWLTRLMGTVTGGFFHRFNRFFDSASNRYVSA 539 Query: 539 ADFVIRHTVVMLALYLVLIGSAGWL-LATTSQGFIPAQDRGYVIISAQLPGAASLARTTA 597 +R +V+++ LY +G WL GF+PAQD+ Y++ AQLP ASL RT A Sbjct: 540 VRRAVRGSVIVMVLYAGFVGLT-WLGFHQVPNGFVPAQDKYYLVGIAQLPSGASLDRTEA 598 Query: 598 VVREIERIALDTPGIVRVAAFAGFSGATRTQQGNAAALFPVFDEPEARLKKGLTANAITA 657 VV+++ IAL PG+ V F G S N+A +F + + R L+ANAI Sbjct: 599 VVKQMSAIALAEPGVESVVVFPGLSVNGPVNVPNSALMFAMLKPFDEREDPSLSANAIAG 658 Query: 658 ELRKRLSVIQGAFIIVIPPPAVPGIGTGGGFTIRVQDRQGRGPELLASATDELVTAARKS 717 +L + S I FI + PPP VPG+G GGF ++++DR G E + E+++ A ++ Sbjct: 659 KLMHKFSHIPDGFIGIFPPPPVPGLGATGGFKLQIEDRAELGFEAMTKVQSEIMSKAMQT 718 Query: 718 PSLTSVFSPFTANTPQLFVDIDRVKAQKLGVPIANINDTIQTYFGSTYVNDFNLFGRTYH 777 P L ++ + F N PQL VDIDRVKA+ +GV + +I +T+Q GS YVNDFN FGR + Sbjct: 719 PELANMLASFQTNAPQLQVDIDRVKAKSMGVSLTDIFETLQINLGSLYVNDFNRFGRAWR 778 Query: 778 VTAQADLPFRKDSPDLARLRTRNVAGDMVMLGSIVDFKDVSGPDRVARYNLYSASELQGE 837 V AQAD PFR D+ L+ RN G+M+ L + V SGPDR+ YN + + ++ G Sbjct: 779 VMAQADAPFRMQQEDIGLLKVRNAKGEMIPLSAFVTIMRQSGPDRIIHYNGFPSVDISGG 838 Query: 838 PAPGVSSTTALNTIKQLADQTLPSGFSFEWTDLSYQQVTGANAGLYVFPICVLFVYLVLA 897 PAPG SS A + I+++ +TLP G FEWTDL YQ+ N+ L +F + VL +L+LA Sbjct: 839 PAPGFSSGQATDAIEKIVRETLPEGMVFEWTDLVYQEKQAGNSALAIFALAVLLAFLILA 898 Query: 898 AQYGSWTLPFAVILIVPMCLFAATIGVRIMGQDVNILTQIGFVVLVGLAAKNAILIVEFA 957 AQY SW+LPFAV+LI PM L +A +GV + G D NI TQIGFVVLVGLAAKNAILIVEFA Sbjct: 899 AQYNSWSLPFAVLLIAPMSLLSAIVGVWVSGGDNNIFTQIGFVVLVGLAAKNAILIVEFA 958 Query: 958 RDIELEGRSRLDAVIEACRLRLRPILMTSFAFILGVLPLVVSTGSGSEMRQAVGVAVFFG 1017 R E +G L AV+EA RLRLRPILMTSFAFI GV+PLV++TG+G+EMR A+G+AVF G Sbjct: 959 RAKEHDGADPLTAVLEASRLRLRPILMTSFAFIAGVVPLVLATGAGAEMRHAMGIAVFAG 1018 Query: 1018 MLGVTLFGLVFTPIFYMVVRNLA 1040 MLGVTLFGL+ TP+FY+VVR +A Sbjct: 1019 MLGVTLFGLLLTPVFYVVVRRMA 1041 >PA3522 [V] COG0841 Cation/multidrug efflux pump Pae Pseudomonas aeruginosa Length = 1053 Score = 978 bits (2527), Expect = 0.0, Method: Compositional matrix adjust. Identities = 541/1040 (52%), Positives = 715/1040 (68%), Gaps = 6/1040 (0%) Query: 1 MNLGRLSINQPILAMVLSIVLLIVGAIAYPTLPVSEYPQVVPPTVVVTTQYPGASAQTVS 60 M R I++PI A+VLS++++I G +++ LP+SEYP V PPTV VTT YPGA+ ++ Sbjct: 1 MTFPRFFIDRPIFAIVLSVLMMIGGIVSFFQLPLSEYPAVTPPTVQVTTAYPGANPDVIA 60 Query: 61 DTVAAPIEQEINGVEDMLYLYSQATSNGQLTITATFKLGTDLDKAQVLVQNRVAIAQPRL 120 TVA P+EQ I GVE MLY+ SQ+ ++G++ +T TF D D AQ+ VQNRV+ RL Sbjct: 61 QTVATPLEQAITGVEGMLYMSSQSATDGRMILTITFDQHIDPDMAQIQVQNRVSRVLSRL 120 Query: 121 PEEVQRNGVTTRKNSPDILMVVFMLSPDDTFDQLYISNYALLQVRDQLLRLDGVGDIQMF 180 P+EVQR GV T+K SPDILMVV +LSP+ +D LYISNYA LQVRD+LLRL G+ D+ ++ Sbjct: 121 PDEVQRQGVVTQKTSPDILMVVHLLSPEQRYDPLYISNYAYLQVRDELLRLPGISDVVVW 180 Query: 181 GARDYSMRLWLDPDRIANLGLTSTEVLAAIRAQNLQIAGGQIAEPPIADRAFQPNLVFTG 240 GA +YSMRLWLDPD IA GLT+ EV+AA+R QN+Q+A G + + P + AFQ + G Sbjct: 181 GAGEYSMRLWLDPDLIAARGLTAGEVIAAVREQNVQVAAGAVGQAPDSTAAFQVTVNTLG 240 Query: 241 RLKDIRQFEDIVVKAGSDGRTVRLRDVARVELGALSYATNSFLLRKSAVALLVTQRPGSN 300 RL D QF DI+V+ G+DG+ RLRDVAR+E+G +YA S L + AVAL + Q PG+N Sbjct: 241 RLSDEEQFGDIIVRTGADGQVTRLRDVARIEMGGDAYALRSLLDGEPAVALQIIQSPGAN 300 Query: 301 ALATAKSISDTMERMKASFPKGLDYNIGYNPTEFIAQSVHELIKTIYEAMALVVIVVLVF 360 AL TA+++ T+ R++ +FP GL I Y+PT F+ S+ + T+ EA+ LVV+VV++F Sbjct: 301 ALDTAEAVRATVARLEGNFPAGLSARIAYDPTVFVRASLQTVATTLLEAILLVVVVVVLF 360 Query: 361 LQGWRPAIIPIIAIPVSLVGTFAVMAALGFSINNLTLFGLVLAVGIVVDDAIVVVENVER 420 L+ WR ++IP++A+PVSLVGTFAVM +GFS+N L+LFGLVL++GIVVDDAIVVVENVER Sbjct: 361 LRSWRASLIPLMAVPVSLVGTFAVMHLMGFSLNTLSLFGLVLSIGIVVDDAIVVVENVER 420 Query: 421 HLEHGMSRRDAALKTMEEVGGALVSIALVLCAVFVPTAFLGGISGQFFQQFAVTIAVATA 480 H+E+G AA + M+EV G +++I VL AVF+PTAFL G+ G+F++QFA+TIA++T Sbjct: 421 HIENGEPPLQAARRAMDEVTGPIMAITSVLAAVFIPTAFLSGLQGEFYRQFALTIAISTI 480 Query: 481 ISCFCSLTLSPALASQILVPHEEKRPPARWNIIARGWDSFTALFNRVFDRLAHGYASVAD 540 +S SLTLSPALA +L P PA + R + + R Y + Sbjct: 481 LSALNSLTLSPALAGLLLRPR-----PAGGAVAGR-FQRLLQVLGRPLRNAPEAYGNAVR 534 Query: 541 FVIRHTVVMLALYLVLIGSAGWLLATTSQGFIPAQDRGYVIISAQLPGAASLARTTAVVR 600 V+R + + L +Y L+G GF+P QD+ Y++ AQLP ASL RT AVVR Sbjct: 535 KVVRVSGLALVVYGGLLGLTWVGFQAVPPGFVPMQDKYYLVGIAQLPNGASLERTDAVVR 594 Query: 601 EIERIALDTPGIVRVAAFAGFSGATRTQQGNAAALFPVFDEPEARLKKGLTANAITAELR 660 ++ RI LD PG+ V AF G S NAA +F + D E+R L A AI L+ Sbjct: 595 QMSRIGLDEPGVESVVAFPGLSVNGFVNVPNAAVMFFMLDPFESRTSADLGALAIAGRLQ 654 Query: 661 KRLSVIQGAFIIVIPPPAVPGIGTGGGFTIRVQDRQGRGPELLASATDELVTAARKSPSL 720 R + I F+ V PPP VPG+GT GGF ++V+DR G G E LA T L+ A +S L Sbjct: 655 ARFASIPDGFLGVFPPPPVPGLGTIGGFKMQVEDRGGAGLEALARQTQVLMMKATESGQL 714 Query: 721 TSVFSPFTANTPQLFVDIDRVKAQKLGVPIANINDTIQTYFGSTYVNDFNLFGRTYHVTA 780 + + F N PQL V +DR K + GV +A++ + +Q Y GS Y+NDFN FGRTY VTA Sbjct: 715 GGLMTSFDINAPQLEVVVDRTKVKSQGVRLADVFEALQVYLGSLYINDFNRFGRTYKVTA 774 Query: 781 QADLPFRKDSPDLARLRTRNVAGDMVMLGSIVDFKDVSGPDRVARYNLYSASELQGEPAP 840 QAD P R + + RL+ RN AG M+ L S V SGPDRV YN Y ++++ G P Sbjct: 775 QADAPHRMQAEAIGRLQVRNAAGAMLPLSSFVTVTPSSGPDRVIHYNGYPSADISGGALP 834 Query: 841 GVSSTTALNTIKQLADQTLPSGFSFEWTDLSYQQVTGANAGLYVFPICVLFVYLVLAAQY 900 GVSS A+ +++LA + LP G +FEWTDL+YQQ N+ L++FP+CVL YL+LAAQY Sbjct: 835 GVSSGQAVALMERLAGEVLPEGMTFEWTDLTYQQKLAGNSALFIFPLCVLLAYLILAAQY 894 Query: 901 GSWTLPFAVILIVPMCLFAATIGVRIMGQDVNILTQIGFVVLVGLAAKNAILIVEFARDI 960 SW LP AV+LIVPMCL +A GV ++G D N+ QIG VVLVGLAAKNAILIVEFAR + Sbjct: 895 NSWLLPLAVLLIVPMCLLSAIAGVWLVGGDNNVFVQIGLVVLVGLAAKNAILIVEFARTL 954 Query: 961 ELEGRSRLDAVIEACRLRLRPILMTSFAFILGVLPLVVSTGSGSEMRQAVGVAVFFGMLG 1020 E EG L+AV+EACRLRLRPILMTS AFI GV+PLV+++G+G+EMRQA+GVAVF GMLG Sbjct: 955 EAEGARALEAVVEACRLRLRPILMTSLAFIAGVVPLVMASGAGAEMRQAMGVAVFAGMLG 1014 Query: 1021 VTLFGLVFTPIFYMVVRNLA 1040 VTLFGL TP+FY++VR LA Sbjct: 1015 VTLFGLFLTPVFYVLVRALA 1034