BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0016.p (416 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BMEII0813 [HE] COG0111 Phosphoglycerate dehydrogenase and relate... 564 e-160 HI0465 [HE] COG0111 Phosphoglycerate dehydrogenase and related d... 458 e-128 XF2206 [HE] COG0111 Phosphoglycerate dehydrogenase and related d... 456 e-128 PA0316 [HE] COG0111 Phosphoglycerate dehydrogenase and related d... 449 e-126 PM1671 [HE] COG0111 Phosphoglycerate dehydrogenase and related d... 444 e-124 >BMEII0813 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Bme Brucella melitensis Length = 412 Score = 564 bits (1453), Expect = e-160, Method: Compositional matrix adjust. Identities = 270/408 (66%), Positives = 332/408 (81%) Query: 2 LSLPKTKIRVLLLEGVNESAARMFEANGYTELQRLPKALGPKELRQALSGIHMLGIRSRT 61 LSL + +I VLLLEG++++A F+++GYT + LPKAL +L +A+S H++GIRSRT Sbjct: 5 LSLSRDRINVLLLEGISQTAVEYFKSSGYTNVTHLPKALDKADLIKAISSAHIIGIRSRT 64 Query: 62 QLTADIMEAADRLLVVGCFSVGTNQVDLDAARKLGIPVFNAPYSNTRSVAELTIAEIVML 121 QLT +I AADRL+ VGCFSVGTNQV+L AARK GIPVFNAP+SNTRSVAEL I EI+ML Sbjct: 65 QLTEEIFAAADRLIAVGCFSVGTNQVELKAARKRGIPVFNAPFSNTRSVAELVIGEIIML 124 Query: 122 FRRIFPRSVSAHAGGWDKSAEGSREVRGKTLGIVGYGNIGSQLSNLAEAMGMRVIYFDQT 181 RRIFPRSVSAHAGGW+K+A GSREVRGKTLGIVGYGNIGSQ+ NLAE++GM V Y+D + Sbjct: 125 MRRIFPRSVSAHAGGWEKTAIGSREVRGKTLGIVGYGNIGSQVGNLAESLGMTVRYYDTS 184 Query: 182 DKLRHGNTEPAESLDALLAASDVVSLHVPETPATANMIGAAQLQLMKPEAYLINNSRGTV 241 DKL++GN +PA SLD LL SDVVSLHVP + +T+ +I A+L+ MK A+LINN+RG+V Sbjct: 185 DKLQYGNVKPAASLDELLKTSDVVSLHVPSSKSTSKLITEAKLRKMKKGAFLINNARGSV 244 Query: 242 VDLDALAGALREGRLAGAAVDVFPVEPVSNEARFVSPLQGLPNVILTPHVGGSTEEAQDR 301 VDL+ALA L+EG LAGAA+DVFPVEP SN RF +PLQGL NVILTPH+GGSTEEAQ+R Sbjct: 245 VDLEALAKVLQEGHLAGAAIDVFPVEPASNGERFSTPLQGLENVILTPHIGGSTEEAQER 304 Query: 302 IGGEVARKLIDYSDVGSTFGAVNFPQVQLPARPTGTRFIHVHRNVPGVMRQVNDAVSRHG 361 IG EV RKL++YSDVGST AVNFPQVQLP RPTGTRF+HVH N PG++ + + S H Sbjct: 305 IGTEVTRKLVEYSDVGSTVSAVNFPQVQLPPRPTGTRFMHVHENRPGILNSLMNVFSHHH 364 Query: 362 INILAQYLQTDPEVGYVVLETDVVGGEGEGLLADLKGIDGTIRVRVLY 409 INI +Q+LQTD EVGY+V+E D VG + +L +++ I GTIR R+LY Sbjct: 365 INIASQFLQTDGEVGYLVMEADGVGEASDAVLQEIREIPGTIRARLLY 412 >HI0465 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Hin Haemophilus influenzae Length = 410 Score = 458 bits (1178), Expect = e-128, Method: Compositional matrix adjust. Identities = 224/408 (54%), Positives = 294/408 (72%), Gaps = 2/408 (0%) Query: 2 LSLPKTKIRVLLLEGVNESAARMFEANGYTELQRLPKALGPKELRQALSGIHMLGIRSRT 61 +SL K+KI+ +L EGV++SA A GYT + KAL EL++A+ +H +G+RSRT Sbjct: 5 VSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGLRSRT 64 Query: 62 QLTADIMEAADRLLVVGCFSVGTNQVDLDAARKLGIPVFNAPYSNTRSVAELTIAEIVML 121 LTA+++EAA +L+ VGCF +GTNQVDL+AA+ GIPVFNAP+SNTRSVAEL + EI++L Sbjct: 65 HLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILLL 124 Query: 122 FRRIFPRSVSAHAGGWDKSAEGSREVRGKTLGIVGYGNIGSQLSNLAEAMGMRVIYFDQT 181 R + + H G W+KSA GS EVRGK LGI+GYG+IGSQLS +AE++GM V ++D Sbjct: 125 MRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYFYDIE 184 Query: 182 DKLRHGNTEPAESLDALLAASDVVSLHVPETPATANMIGAAQLQLMKPEAYLINNSRGTV 241 +KL GN + SL+ LL++ DVVSLHVPE P+T N++ A++ +K A LIN +RGTV Sbjct: 185 NKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAARGTV 244 Query: 242 VDLDALAGALREGRLAGAAVDVFPVEPVSNEARFVSPLQGLPNVILTPHVGGSTEEAQDR 301 VD+DALA AL++G+L GAA+DVFPVEP S F+SPL+ NVILTPH+GGST EAQ+ Sbjct: 245 VDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAEAQEN 304 Query: 302 IGGEVARKLIDYSDVGSTFGAVNFPQVQLPARPTGTRFIHVHRNVPGVMRQVNDAVSRHG 361 IG EVA K + YSD GST +VNFP+V LP R +H+H N PG++ ++N Sbjct: 305 IGFEVAGKFVKYSDNGSTLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEAN 364 Query: 362 INILAQYLQTDPEVGYVVLETDVVGGEGEGLLADLKGIDGTIRVRVLY 409 +NI AQYLQTDP++GYVV+ DV + LL LK IDGTIR RVLY Sbjct: 365 LNIAAQYLQTDPKIGYVVV--DVETNDASPLLTKLKEIDGTIRARVLY 410 >XF2206 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Xfa Xylella fastidiosa 9a5c Length = 413 Score = 456 bits (1174), Expect = e-128, Method: Compositional matrix adjust. Identities = 230/407 (56%), Positives = 284/407 (69%) Query: 3 SLPKTKIRVLLLEGVNESAARMFEANGYTELQRLPKALGPKELRQALSGIHMLGIRSRTQ 62 S PK IR+LLLEGV+ S F A GY++++ +L + L+ ++ H++GIRSRTQ Sbjct: 7 SFPKQDIRILLLEGVSHSGIETFRAAGYSQIKIHTTSLPEEALQAEIAEAHIIGIRSRTQ 66 Query: 63 LTADIMEAADRLLVVGCFSVGTNQVDLDAARKLGIPVFNAPYSNTRSVAELTIAEIVMLF 122 L A+++ A RL+ +GCF +GTNQVDLD A GIPVFNAPYSNTRSVAEL IAE ++L Sbjct: 67 LNAEVLGHAKRLMAIGCFCIGTNQVDLDTAELSGIPVFNAPYSNTRSVAELIIAEAILLL 126 Query: 123 RRIFPRSVSAHAGGWDKSAEGSREVRGKTLGIVGYGNIGSQLSNLAEAMGMRVIYFDQTD 182 R I ++ H GGW KSA S E RGK LGIVGYG+IG+Q+S LAEAMGM+VI++D Sbjct: 127 RGIPQKNAECHRGGWSKSAINSHEARGKVLGIVGYGHIGTQVSVLAEAMGMQVIFYDIES 186 Query: 183 KLRHGNTEPAESLDALLAASDVVSLHVPETPATANMIGAAQLQLMKPEAYLINNSRGTVV 242 KL GN PA SLD LL +DVV+LHVPET AT NM+G A+L MKP A+LIN SRGTVV Sbjct: 187 KLSLGNARPAASLDELLGIADVVTLHVPETAATKNMLGHAELARMKPGAHLINASRGTVV 246 Query: 243 DLDALAGALREGRLAGAAVDVFPVEPVSNEARFVSPLQGLPNVILTPHVGGSTEEAQDRI 302 ++DAL AL G L GAAVDVFP EP N F+SPL NVILTPH+GGST EAQD I Sbjct: 247 EIDALDAALVSGHLGGAAVDVFPSEPKGNSDPFISPLSRHDNVILTPHIGGSTLEAQDNI 306 Query: 303 GGEVARKLIDYSDVGSTFGAVNFPQVQLPARPTGTRFIHVHRNVPGVMRQVNDAVSRHGI 362 G EVA KLI YSD GST AVNFP+V LP R +H+HRNVPGV+ +N+ SRH + Sbjct: 307 GIEVAAKLIRYSDNGSTLSAVNFPEVSLPEHVGSMRLLHIHRNVPGVLSHINELFSRHNV 366 Query: 363 NILAQYLQTDPEVGYVVLETDVVGGEGEGLLADLKGIDGTIRVRVLY 409 NI Q+L+TD +GYVV++ + L L + GT+R R+LY Sbjct: 367 NIDGQFLRTDATLGYVVIDIGASQTQALALKEALTQVPGTLRTRLLY 413 >PA0316 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Pae Pseudomonas aeruginosa Length = 409 Score = 449 bits (1155), Expect = e-126, Method: Compositional matrix adjust. Identities = 224/408 (54%), Positives = 293/408 (71%), Gaps = 4/408 (0%) Query: 3 SLPKTKIRVLLLEGVNESAARMFEANGYTELQRLPKALGPKELRQALSGIHMLGIRSRTQ 62 SL K+KI+ LLLEGV+++A +A GYT ++ L AL EL++ ++ H +GIRSRTQ Sbjct: 5 SLDKSKIKFLLLEGVHQNAVDTLKAAGYTNIEYLKTALSGDELKERIADAHFIGIRSRTQ 64 Query: 63 LTADIMEAADRLLVVGCFSVGTNQVDLDAARKLGIPVFNAPYSNTRSVAELTIAEIVMLF 122 LT ++ + A +L+ VGCF +GTNQVDL+AAR+ GI VFNAPYSNTRSVAEL +AE ++L Sbjct: 65 LTEEVFDCAKKLIAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEAILLL 124 Query: 123 RRIFPRSVSAHAGGWDKSAEGSREVRGKTLGIVGYGNIGSQLSNLAEAMGMRVIYFDQTD 182 R I ++ S H GGW KSA S E+RGK LGIVGYG+IG+QLS LAEA+GM+V ++D Sbjct: 125 RGIPEKNASCHRGGWIKSAANSFEIRGKKLGIVGYGSIGTQLSVLAEALGMQVFFYDTVT 184 Query: 183 KLRHGNTEPAESLDALLAASDVVSLHVPETPATANMIGAAQLQLMKPEAYLINNSRGTVV 242 KL GN SL LL SD+VSLHVPE P+T MIG +++ MK LIN +RGTVV Sbjct: 185 KLPLGNAVQIGSLHELLGMSDIVSLHVPELPSTQWMIGEKEIRAMKKGGILINAARGTVV 244 Query: 243 DLDALAGALREGRLAGAAVDVFPVEPVSNEARFVSPLQGLPNVILTPHVGGSTEEAQDRI 302 +LD LA A+++ L GAA+DVFPVEP SN+ F SPL+GL VILTPH+GGST EAQ I Sbjct: 245 ELDHLAAAIKDEHLIGAAIDVFPVEPKSNDEEFASPLRGLDRVILTPHIGGSTAEAQANI 304 Query: 303 GGEVARKLIDYSDVGSTFGAVNFPQVQLPARPTGTRFIHVHRNVPGVMRQVNDAVSRHGI 362 G EVA KL+ YSD G++ +VNFP+V LP+ P R +H+H N+PGVM ++N + +GI Sbjct: 305 GLEVAEKLVKYSDNGTSVSSVNFPEVALPSHPGKHRLLHIHANIPGVMSEINKVFADNGI 364 Query: 363 NILAQYLQTDPEVGYVVLETDVVGGEGEGL-LADLKGIDGTIRVRVLY 409 N+ QYLQT+ +VGYVV++ D E L L L+ ++GTIR RVL+ Sbjct: 365 NVSGQYLQTNEKVGYVVIDVD---AEYSDLALEKLQQVNGTIRSRVLF 409 >PM1671 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases Pmu Pasteurella multocida Length = 410 Score = 444 bits (1141), Expect = e-124, Method: Compositional matrix adjust. Identities = 218/408 (53%), Positives = 288/408 (70%), Gaps = 2/408 (0%) Query: 2 LSLPKTKIRVLLLEGVNESAARMFEANGYTELQRLPKALGPKELRQALSGIHMLGIRSRT 61 +SL K+KI+ LLLEGV+++A + + GYT ++ KAL EL++A+ H +GIRSRT Sbjct: 5 VSLDKSKIKFLLLEGVHQTALEVLQNAGYTNIEYHKKALDDDELKEAIKDAHFVGIRSRT 64 Query: 62 QLTADIMEAADRLLVVGCFSVGTNQVDLDAARKLGIPVFNAPYSNTRSVAELTIAEIVML 121 LT +++ A +L+ +GCF +GTNQV+L AA+ GIPVFNAP+SNTRSVAEL + EI++L Sbjct: 65 FLTEEVLAHAQKLIAIGCFCIGTNQVNLQAAKLRGIPVFNAPFSNTRSVAELVLGEILLL 124 Query: 122 FRRIFPRSVSAHAGGWDKSAEGSREVRGKTLGIVGYGNIGSQLSNLAEAMGMRVIYFDQT 181 R + + H G W+KSA GS EVRGK LGI+GYG+IGSQLS +AE++GMRV ++D Sbjct: 125 MRNVPQANAEVHRGIWNKSANGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMRVFFYDIE 184 Query: 182 DKLRHGNTEPAESLDALLAASDVVSLHVPETPATANMIGAAQLQLMKPEAYLINNSRGTV 241 +KL GN + +L+ LL++ DVVSLHVPE +T N+I A ++ +K A LIN +RGTV Sbjct: 185 NKLPLGNAQQLRTLEELLSSCDVVSLHVPENASTKNLISAERIAQLKEGAILINAARGTV 244 Query: 242 VDLDALAGALREGRLAGAAVDVFPVEPVSNEARFVSPLQGLPNVILTPHVGGSTEEAQDR 301 VD+DALA AL G++ GAA+DVFP EP S + FVSPL+ NVILTPH+GGST EAQ+ Sbjct: 245 VDIDALAQALEAGKIRGAALDVFPEEPASIQEEFVSPLRAFDNVILTPHIGGSTSEAQEN 304 Query: 302 IGGEVARKLIDYSDVGSTFGAVNFPQVQLPARPTGTRFIHVHRNVPGVMRQVNDAVSRHG 361 IG EV+ K + YSD GST AVNFP+V LP R +H+H N GV+ ++N Sbjct: 305 IGAEVSGKFVKYSDNGSTLSAVNFPEVSLPEHVGTKRLLHIHHNKQGVLNKINQVFVDAN 364 Query: 362 INILAQYLQTDPEVGYVVLETDVVGGEGEGLLADLKGIDGTIRVRVLY 409 +NI AQYLQTDP +GYVV+ DV + LL LK I+GTIR RVLY Sbjct: 365 VNIAAQYLQTDPAIGYVVI--DVETEDTHSLLTQLKEIEGTIRARVLY 410