BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0022.0014.p         (199 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

AF0907 [GEPR] COG0477 Permeases of the major facilitator superfa...    75   6e-14
MA4166 [GEPR] COG0477 Permeases of the major facilitator superfa...    64   3e-10

>AF0907 [GEPR] COG0477 Permeases of the major facilitator superfamily Afu
           Archaeoglobus fulgidus
          Length = 419

 Score = 75.5 bits (184), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 46/153 (30%), Positives = 79/153 (51%)

Query: 24  LASGHMLSTLLRTIPAISLDLMASDFGTSPQALASLTSIYHFSFAASQIPVGAAMDRFGV 83
           +AS +      RT  AI    +  +F  +  A+  L+S Y + +   QIPVG   D  G 
Sbjct: 27  MASIYFFVYFHRTSSAILATTLMEEFAVTALAVGVLSSAYFYPYGLMQIPVGYLSDTKGP 86

Query: 84  RPVSLSLLAGTVIGTLVSALATGPASFVLGQLMLGVATSGMLMCPMTLAAKQMSAAKFGL 143
           R  +        +GT++ A++      VLG+ ++G+  SG+ +  + L ++     +F  
Sbjct: 87  RLTTTVFTLLAFVGTVLFAVSPNFEVAVLGRFLIGIGVSGVYIPTIKLLSRWFRVDEFAT 146

Query: 144 WSGLILSIGNIGMLLSASPLAFVVDQFGWRAGF 176
            +G++ ++GN+G L+SA PLA +V  FGWR  F
Sbjct: 147 LTGVLFAVGNMGALVSAYPLATMVSLFGWRVTF 179


>MA4166 [GEPR] COG0477 Permeases of the major facilitator superfamily Mac
           Methanosarcina acetivorans str.C2A
          Length = 444

 Score = 63.5 bits (153), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 52/189 (27%), Positives = 102/189 (53%), Gaps = 15/189 (7%)

Query: 14  FRALVLALLALASG----HMLSTLLRTIPAISLDLMASDFGTSPQALASLTSIYHFSFAA 69
           +R +V  +LA A      H +ST +     ++ D+M + FG    ++  L S Y +++ A
Sbjct: 3   YRWVVFVILAFAYFFVYFHRVSTAV-----VAADIM-NTFGVGAASIGLLGSAYFYAYTA 56

Query: 70  SQIPVGAAMDRFGVRPVS--LSLLAGTVIGTLVSALATGPASFVLGQLMLGVATSGMLMC 127
            Q+P G   D +GV+  +   +LLA   +G +++ +A+     ++G++++G+  + + + 
Sbjct: 57  MQLPSGILSDSWGVKKTAGVFTLLAA--VGAVLTGVASNFTMVLIGRVLIGIGVAMVYIP 114

Query: 128 PMTLAAKQMSAAKFGLWSGLILSIGNIGMLLSASPLAFVVDQFG-WRAGFWVSAGFGIVV 186
            M + A      +F   SG++L+IGNIG L +A PLA +   FG W+  F +   F +++
Sbjct: 115 VMKVLAIWFKKNEFASMSGVLLAIGNIGALSAAGPLAIMAAAFGDWQKVFLMLGLFSVLL 174

Query: 187 LIAVFAXAR 195
            +A+F   +
Sbjct: 175 AVAIFVLVK 183