BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0018.0010.p (434 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2210 [GEPR] COG0477 Permeases of the major facilitator superfa... 347 3e-95 RSp1614 [GEPR] COG0477 Permeases of the major facilitator superf... 239 7e-63 BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superf... 206 8e-53 SSO2718 [GEPR] COG0477 Permeases of the major facilitator superf... 197 5e-50 BS_yybO [GEPR] COG0477 Permeases of the major facilitator superf... 189 1e-47 >PA2210 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 441 Score = 347 bits (890), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 191/424 (45%), Positives = 265/424 (62%), Gaps = 10/424 (2%) Query: 11 ADTAKPSGVRWKIFLLMLFLISINYIDRASLSVAMPVIAKEFDIDPAMQGLILSSFFWTY 70 A AKPS VRW+IF ++ L IN +DR SLS+AMP IA EF + P+MQGLILSSFFW Y Sbjct: 18 ATAAKPSNVRWRIFAIVFALTVINLVDRVSLSIAMPTIAGEFQLTPSMQGLILSSFFWAY 77 Query: 71 ALMQVPGGMLADRFKPRIVIALATLFWGFFQALAALSTSWMLLLLTRLGLGASEAPIYPA 130 AL+Q+PGG L DR+ PR VI +T WG FQ LAA ++ + L+ R+ LGA+EAP++P+ Sbjct: 78 ALLQIPGGWLIDRYGPRRVIGWSTGLWGAFQTLAAFASGGLSLMFARVALGAAEAPLFPS 137 Query: 131 GGKLNAIWMTQTERGRGATLLDGGAPLGAALGSIVIAWLMAAFSSWRVAFVIAGVGTMLC 190 GGKLN++W+ +ER RGA L+D G PLG ALG +VIA+L+A SWR AF IAG+ T+ Sbjct: 138 GGKLNSLWLGSSERSRGAVLMDCGGPLGVALGGLVIAYLIAVLGSWRSAFFIAGIATLAM 197 Query: 191 GLWAWYYIRNVPREHPSVNEAEARYLEEAHAIEDAATPPSSGASWMAYFRF----RSVWC 246 AW+Y+R+ P EHP VN AE L+ +A T P + A A R RS+ Sbjct: 198 AWLAWHYLRDDPAEHPGVNAAE---LDRINADR---TTPLAEADCQAGGRLGIAGRSLVG 251 Query: 247 MCLGWMFFNTTFYGLLTWMPTYLFKVHGFDIKALGGASFIIFFAGFVGELVGGWIGDNWR 306 + LG + F+GLLTW P+YL + GFDIK +G A+F+IF G VG LVGG++ D Sbjct: 252 IVLGRASWAMVFFGLLTWGPSYLAQARGFDIKGIGAATFVIFLCGAVGSLVGGFLCDLLI 311 Query: 307 ERGGAPNTVFRTLFGIAAIMATVSIFLVAYVTNAVAVVVLLSTTLFFLRWCGMYWAIPSA 366 +G + L ++ + A V+ L+ + +A A V LL+ T FFL W +YW+ P+ Sbjct: 312 RKGVRRGLAAKGLLTVSGLAALVAFLLLPSLEDAYAAVTLLALTAFFLMWGSLYWSFPAL 371 Query: 367 LAGRGKSGFLGGCMNLGGNIAGITTPLIVGFIVQATGSYFLALMYFAAAGIALLICSTMI 426 LA + G +GG MN+ G++ GI P++VG ++Q G Y L +FA A + + +I Sbjct: 372 LATPARVGLVGGVMNMAGSLGGIAVPILVGLLLQHLGGYAAVLGFFALCSAAFIAGTLLI 431 Query: 427 DYSR 430 + Sbjct: 432 SLDK 435 >RSp1614 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 448 Score = 239 bits (611), Expect = 7e-63, Method: Compositional matrix adjust. Identities = 157/440 (35%), Positives = 232/440 (52%), Gaps = 30/440 (6%) Query: 10 MADT---AKPSGVRWKIFLLMLFLISINYIDRASLSVAMPVIAKEFDIDPAMQGLILSSF 66 M DT + S VRW + LM I+INYIDR LS A P I KEF + G+++S+F Sbjct: 1 MQDTPQRGQRSKVRWLVAGLMWAAIAINYIDRTVLSAAAPHIQKEFHLSAVEMGVVMSAF 60 Query: 67 FWTYALMQVPGGMLADRFKPRIVIALATLFWGFFQALAALSTSWMLLLLTRLGLGASEAP 126 FW+YAL+Q+P G+LADRF + V+ A L+W A+ L+T + L+ R+ LG EA Sbjct: 61 FWSYALLQLPAGILADRFGQKKVLGFAVLWWSLATAVTGLATGFKSLVGLRVALGVGEAG 120 Query: 127 IYPAGGKLNAIWMTQTERGRGATLLDGGAPLGAALGSIVIAWLMAAFSSWRVAFVIAG-V 185 YP+ + + W + ER A + D G+ LG+A+ +IAWL+ F W++ F +AG + Sbjct: 121 AYPSNAGITSRWFPKQERATVAAIFDSGSKLGSAIALPLIAWLLVTF-DWKITFTVAGSL 179 Query: 186 GTMLCGLWAWYYIRNVPREHPSVNEAEARYLEEAHAIEDAATPPSSGAS-----WMAYFR 240 G + C +WA + R+ P EH VN AE ++++ PP+ GA W Sbjct: 180 GIVWCVVWALVF-RDSPAEHEGVNAAELAHIQK-------GLPPARGADAPAMPWTKLLT 231 Query: 241 FRSVWCMCLGWMFFNTTFYGLLTWMPTYLFKVHGFDIKALG-GASFIIFFAGFVGELVGG 299 R+VW MC+G+ N Y +TW+PTYL K G + +G AS +F + FV E+ G Sbjct: 232 HRNVWAMCIGFFMINYNSYFFITWLPTYLVKERGMGLMEMGFMASLPLFVSMFV-EVFAG 290 Query: 300 WIGDNWRERGGAPNTVFRTLFGIAAIMATVSIFLVAYVTNAVAVVVLL-----STTLFFL 354 W D G T R LF + ++ SI L A+ +AV V+LL TT+ Sbjct: 291 WASDRVYASGRLSLTATRKLFLVIGLVMASSIGLAAFAQSAVVAVILLCIAKSGTTVA-- 348 Query: 355 RWCGMYWAIPSALAGRGKSGFLGGCMNLGGNIAGITTPLIVGFIVQATGSYFLALMYFAA 414 WA+P+ +A + G N N+ G+ P++ G IV ATGS+ AL+ F+A Sbjct: 349 --ASQVWALPADVAPGNTVSMVAGLQNSVSNMGGVVGPIVTGAIVGATGSFIPALV-FSA 405 Query: 415 AGIALLICSTMIDYSRKLPV 434 A I L I + + + P+ Sbjct: 406 ALIGLAILNYLFLLGKVEPI 425 >BS_ycbE [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 455 Score = 206 bits (524), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 132/419 (31%), Positives = 212/419 (50%), Gaps = 15/419 (3%) Query: 15 KPSGVRWKIFLLMLFLISINYIDRASLSVAMPVIAKEFDIDPAMQGLILSSFFWTYALMQ 74 K + VRW I ++ + SINY DRA+LS+ + + +D G + S+F W Y + Q Sbjct: 13 KKTSVRWFIVFMLFLVTSINYADRATLSITGDSVQHDLGLDSVAMGYVFSAFGWAYVIGQ 72 Query: 75 VPGGMLADRFKPRIVIALATLFWGFFQALA------ALSTSWMLLLLTRLGLGASEAPIY 128 +PGG L DRF + +IAL+ FW FF L + T+ +LL R +G SEAP + Sbjct: 73 LPGGWLLDRFGSKTIIALSIFFWSFFTLLQGAIGFFSAGTAIILLFALRFLVGLSEAPSF 132 Query: 129 PAGGKLNAIWMTQTERGRGATLLDGGAPLGAALGSIVIAWLMAAFSSWRVAFVIAGVGTM 188 P G++ A W +ERG + + + ++ WL +F W FV+ G+ + Sbjct: 133 PGNGRVVASWFPSSERGTASAFFNSAQYFAIVIFPPLMGWLTHSF-GWHSVFVVMGIAGI 191 Query: 189 LCGLWAWYYIRNVPREHPSVNEAEARYLEEAH---AIEDAATPPSSGASW---MAYFRFR 242 L + W P++HP VNEAE Y+E+ +++D+ + + + W R Sbjct: 192 LLAV-IWLKTVYEPKKHPKVNEAELAYIEQGGGLISMDDSKSKQETESKWPYIKQLLTNR 250 Query: 243 SVWCMCLGWMFFNTTFYGLLTWMPTYLFKVHGFDIKALGGASFIIFFAGFVGELVGGWIG 302 + + + T Y LTW P YL + G I G + + GF G ++GG + Sbjct: 251 MLIGVYIAQYCITTLTYFFLTWFPVYLVQARGMSILEAGFVASLPALCGFAGGVLGGIVS 310 Query: 303 DNWRERGGAPNTVFRTLFGIAAIMATVSIFLVAYVTNAVAVVVLLSTTLFFLRWCGMYWA 362 D ++G + T R + IA ++ + S+ + Y +A VVV++S F + + WA Sbjct: 311 DILLKKGRSL-TFARKVPIIAGMLLSCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWA 369 Query: 363 IPSALAGRGKSGFLGGCMNLGGNIAGITTPLIVGFIVQATGSYFLALMYFAAAGIALLI 421 + S + + +G GG N GNIA ITTP+I+G+IV ATGS+ AL++ A IA ++ Sbjct: 370 VVSDTSPKECAGLSGGLFNTFGNIASITTPIIIGYIVNATGSFNGALVFVGANAIAAIL 428 >SSO2718 [GEPR] COG0477 Permeases of the major facilitator superfamily Sso Sulfolobus solfataricus Length = 419 Score = 197 bits (500), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 122/420 (29%), Positives = 209/420 (49%), Gaps = 10/420 (2%) Query: 19 VRWKIFLLMLFLISINYIDRASLSVAMPVIAKEFDIDPAMQGLILSSFFWTYALMQVPGG 78 +RWKI L++ LI ++YIDR ++ A+PV+ EF I G+I F + Y +M G Sbjct: 5 LRWKIVLIIFALIIVDYIDRGLINTALPVLKSEFHISSFEAGIIGDGFTFGYLIMNPLVG 64 Query: 79 MLADRFKPRIVIALATLFWGFFQALAALSTSWMLLLLTRLGLGASEAPIYPAGGKLNAIW 138 D++ P+ V + + WG QA+ + S ++TR+ LG EA +P K+ A W Sbjct: 65 YFLDKYGPKRVFSRFAILWGAVQAINVFAFSTFYFIVTRVLLGIGEAVGFPGVTKIVANW 124 Query: 139 MTQTERGRGATLLDGGAPLGAALGSIVIAWLMAAFSS----WRVAFVIAGVGTMLCGLWA 194 + + E+ RG T+ D G LG GS+ + L A + WR+ F+++G+ ++ + Sbjct: 125 LRKDEKARGGTISDSGVNLGIVFGSLFMLGLFAIIPNQELAWRLGFLVSGLLAIILAIIL 184 Query: 195 WYYIRNVPREHPSVNEAEARYLEEAHAIEDAATPPSSGASWMAYFRFRSVWCMCLGWMFF 254 + ++P +HP +++ E Y+ E S+ + R ++ W G Sbjct: 185 GRLLYDLPEQHPKISKEELDYILSGR--EKVGVKTKLPLSY--WLRSKNYWGYMQGLGAQ 240 Query: 255 NTTFYGLLTWMPTYLFKVHGFDIKALGGASFIIFFAGFVGELVGGWIGDNWRERGGAPNT 314 F+GL TW+P YLF + + +I+ GF+GELVGG++ D +R PN Sbjct: 241 AGIFFGLFTWLPLYLFYARHLSLSFTLEYTALIWSFGFIGELVGGYVVDKLIKRN--PNL 298 Query: 315 VFRTLFGIAAIMATVSIFLVAYVTNAVAVVVLLSTTLFFLRWCGMYWAIPSALAGRGKSG 374 F+ F ++++ T+ + +++ + V +L T FFLRW G+ WA PS L +G Sbjct: 299 GFKVGFAVSSLAVTIGLAAATLISSPIEAVEILMVTFFFLRWSGIQWAAPSFLVSTELAG 358 Query: 375 FLGGCMNLGGNIAGITTPLIVGFIVQATGSYFLALMYFAAAGIALLICSTMIDYSRKLPV 434 GG + + GI P++ G V+ T +Y L + G+ I + +I R++ V Sbjct: 359 QFGGHIGFWETLWGIIVPIVFGATVEVTKAYLLGMEILIGIGLIYFIGTVIITNYRQIKV 418 >BS_yybO [GEPR] COG0477 Permeases of the major facilitator superfamily Bsu Bacillus subtilis Length = 435 Score = 189 bits (480), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 129/425 (30%), Positives = 212/425 (49%), Gaps = 11/425 (2%) Query: 1 MSDQVSTIAMADTAKPSGVRWKIFLLMLFLISINYIDRASLSVAMPVIAKEFDIDPAMQG 60 M+++V ++ +P RW I L+ +I +NY DR ++SVA P I F + G Sbjct: 1 MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVAAPAIQDSFHLTATELG 60 Query: 61 LILSSFFWTYALMQVPGGMLADRFKPRIVIALATLFWGFFQALAALSTSWMLLLLTRLGL 120 ++ S + ++Y LMQ+P G L DRF V + W F L A +LL L R + Sbjct: 61 IVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTILLAFLQGKLLLYLFRFLI 120 Query: 121 GASEAPIYPAGGKLNAIWMTQTERGRGATLLDGGAPLGAALGSIVIAWLMAAFSSWRVAF 180 G + A +PA K A+W +ERG +L D A +G+ ++A+L+ F WRVAF Sbjct: 121 GLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNVIGAPLVAFLVTTF-DWRVAF 179 Query: 181 VIAGVGTMLCGLWAWYYIRNVPREHPSVNEAEARYLEEAHAIEDAATPPSSGASWMAYFR 240 + G +L ++ W Y P H ++++E Y+++ +AI P +G F Sbjct: 180 LTIGCINVLFTIFFWQYYEQ-PERHKRISKSELNYIQKHNAITTEQIPYKTGPLLKKLFT 238 Query: 241 FRSVWCMCLGWMFFNTTFYGLLTWMPTYLFKVHGFDIKALGGASFIIFFAGFV-GELVGG 299 R VW + +G+ + TF LLTW+PT+ +G D+ + G + + + + G VGG Sbjct: 239 NRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLMSSGLFTAVPWLISTISGIAVGG 298 Query: 300 WIGDNWRERGGAPNTVFRTLFGIAAIMATVSIFLVAYVTNAVAV-VVLLSTTLFFLRWCG 358 W+ D + ++G V+RT+ I M+ FL + +TN + V ++ +S L + Sbjct: 299 WLVDYFIKKGYPNTKVYRTV--IIVGMSFGFFFLGSILTNNITVAIICISIGLAGISATA 356 Query: 359 -MYWAIPSALAGRGKSGFLGGCMNLGGNI-AGITTPLIVGFIVQATGSYFLALMYFAAAG 416 + W+I + LA G L +NL N+ GI + G++ TGS+ L+ F AG Sbjct: 357 PVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAASLTGYLFDVTGSFTLS---FLVAG 413 Query: 417 IALLI 421 LL+ Sbjct: 414 FVLLL 418