BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0017.0071.p (263 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CAC3574 [IQR] COG1028 Dehydrogenases with different specificitie... 180 3e-45 alr1894 [IQR] COG1028 Dehydrogenases with different specificitie... 178 1e-44 BH2491 [IQR] COG1028 Dehydrogenases with different specificities... 170 3e-42 SPy1749 [IQR] COG1028 Dehydrogenases with different specificitie... 166 5e-41 BS_fabG [IQR] COG1028 Dehydrogenases with different specificitie... 164 2e-40 >CAC3574 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cac Clostridium acetobutylicum Length = 249 Score = 180 bits (456), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 106/247 (42%), Positives = 147/247 (59%), Gaps = 11/247 (4%) Query: 25 LHGHVALVTGGSRGIGAAIVKMLADAGAAVAINYRERSAAAETLAKGITAAGGRAVAIAA 84 L G VA+VTG RG+G AI LA GA + +NYR A + L K I G +AVA+ A Sbjct: 5 LSGKVAVVTGAGRGLGRAIALKLAAEGANLVVNYRSSEAETQKLIKEIEELGSKAVAVKA 64 Query: 85 DVSEAAAVATLVERAESELGPVDILVNNAGIAIVRGVDDLTEEDFDRTITVNLKSAFLCT 144 D+S+ T++++A E G VDILVNNAGI + + EEDFD I VNLK AF C Sbjct: 65 DISKYDEAETIIKKALDEYGTVDILVNNAGITKDNLLLRMKEEDFDSVINVNLKGAFNCI 124 Query: 145 QAVLPMMRTRKWGRIVNISS--GAARGAGSIGPHYNASKAAMEGMTRGYAARLVKEGITV 202 + +M +K G+I+NISS G AG + +Y A+KA + GMT+ A L GITV Sbjct: 125 KHTSRVMLKKKSGKIINISSVIGLIGNAGQV--NYAAAKAGIIGMTKSVAKELASRGITV 182 Query: 203 NAVAPSLIETDMM-----RGQSELVSRIPMGRFGTAEEVAQAVMLLVNN--PYMTGQTIA 255 NAVAP +I++DM + + +V+ +P+ + G AE+VA V+ L ++ Y+TGQ I Sbjct: 183 NAVAPGIIKSDMTDALTDKQRESIVAAVPLNKVGEAEDVANLVLFLASDLSSYITGQVIN 242 Query: 256 MSGGMAF 262 + GGM Sbjct: 243 VDGGMVM 249 >alr1894 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Nos Nostoc sp. PCC 7120 Length = 251 Score = 178 bits (451), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 108/246 (43%), Positives = 146/246 (59%), Gaps = 5/246 (2%) Query: 20 MTTSSLHGHVALVTGGSRGIGAAIVKMLADAGAAVAINYRERSAAAETLAKGITAAGGRA 79 + + +L G VA+VTG SRGIG AI LA+ GA V +NY S AA+ + IT AGG A Sbjct: 3 ILSENLRGQVAVVTGASRGIGRAIALELANYGATVVVNYASSSTAADEVVAEITGAGGEA 62 Query: 80 VAIAADVSEAAAVATLVERAESELGPVDILVNNAGIAIVRGVDDLTEEDFDRTITVNLKS 139 VA+ ADVS+ V L+ A + +DILVNNAGI + + ED+ I +NL Sbjct: 63 VALKADVSQVEQVDNLINGAIDKFKRIDILVNNAGITRDTLLLRMKPEDWQAVIDLNLTG 122 Query: 140 AFLCTQAVLPMMRTRKWGRIVNISSGAARGAGSIGPHYNASKAAMEGMTRGYAARLVKEG 199 FLCT+AV +M ++ GRI+NI+S A + +Y+A+KA + G T+ A L G Sbjct: 123 VFLCTRAVSKLMLKQRSGRIINITSVAGQMGNPGQANYSAAKAGVIGFTKTVAKELASRG 182 Query: 200 ITVNAVAPSLIETDMMRG-QSE-LVSRIPMGRFGTAEEVAQAVMLLVNNP---YMTGQTI 254 ITVNAVAP I TDM +SE ++ IP+GR+G EE+A V L +P Y+TGQ Sbjct: 183 ITVNAVAPGFIATDMTSNLKSEGILQYIPLGRYGQPEEIAGMVRFLAADPAAAYITGQVF 242 Query: 255 AMSGGM 260 + GGM Sbjct: 243 NVDGGM 248 >BH2491 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bha Bacillus halodurans Length = 246 Score = 170 bits (430), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 109/246 (44%), Positives = 145/246 (58%), Gaps = 13/246 (5%) Query: 25 LHGHVALVTGGSRGIGAAIVKMLADAGAAVAINYRERSAAAETLAKGITAAGGRAVAIAA 84 L G A+VTG SRGIG A LA GA V +NY AE + I G A+AI A Sbjct: 2 LQGKTAIVTGASRGIGRATAMELARHGANVVVNYAGNKEKAEKVVAEIKELGVEAIAIQA 61 Query: 85 DVSEAAAVATLVERAESELGPVDILVNNAGIAIVRGVDDLTEEDFDRTITVNLKSAFLCT 144 DV+++ +V +V+ G VDILVNNAGI + EED+D I NLK F C+ Sbjct: 62 DVADSESVQAMVKETIDTFGAVDILVNNAGITRDNLFMRMKEEDWDAVIDTNLKGVFHCS 121 Query: 145 QAVL-PMMRTRKWGRIVNISS--GAARGAGSIGPHYNASKAAMEGMTRGYAARLVKEGIT 201 +AV PMM+ R +GRI+N+SS GA AG +Y A+KA + G+T+ A L IT Sbjct: 122 KAVTRPMMKQR-FGRIINVSSVVGAIGNAGQ--ANYVAAKAGVIGLTKTLARELANRNIT 178 Query: 202 VNAVAPSLIETDMM-----RGQSELVSRIPMGRFGTAEEVAQAVMLLVNN--PYMTGQTI 254 VNAVAP IETDM +++++ +IP+ R G EEVA+AV L ++ Y+TGQTI Sbjct: 179 VNAVAPGFIETDMTGELPEDVKAQMLGQIPLARLGQPEEVAKAVRFLASDDASYLTGQTI 238 Query: 255 AMSGGM 260 ++GGM Sbjct: 239 HVNGGM 244 >SPy1749 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Spy Streptococcus pyogenes M1 GAS Length = 244 Score = 166 bits (420), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 103/243 (42%), Positives = 141/243 (58%), Gaps = 11/243 (4%) Query: 25 LHGHVALVTGGSRGIGAAIVKMLADAGAAVAINYRERSAAAETLAKGITAAGGRAVAIAA 84 + G +TG +RGIG A+ A A + +N RSA +E L T G V I+ Sbjct: 3 IKGKNIFITGSTRGIGLAMAHQFASLEANIVLN--GRSAISEELVASFTDYGVTVVTISG 60 Query: 85 DVSEAAAVATLVERAESELGPVDILVNNAGIAIVRGVDDLTEEDFDRTITVNLKSAFLCT 144 DVSEA+ +V A LG +D+LVNNAGI + + +TEEDF+R + +NL AF T Sbjct: 61 DVSEASEAKRMVNEAIESLGSIDVLVNNAGITNDKLMLKMTEEDFERVLKINLTGAFNMT 120 Query: 145 QAVL-PMMRTRKWGRIVNISSGAARGAGSIGP-HYNASKAAMEGMTRGYAARLVKEGITV 202 Q+VL PM++ R+ G I+N+SS G+IG +Y ASKA M G T+ A + I V Sbjct: 121 QSVLKPMIKARQ-GAIINVSSVVGL-TGNIGQANYAASKAGMIGFTKSVAREVAARNICV 178 Query: 203 NAVAPSLIETDMM-----RGQSELVSRIPMGRFGTAEEVAQAVMLLVNNPYMTGQTIAMS 257 NA+AP IE+DM + Q +++S+IPM R G A+EVA LV Y+TGQ IA+ Sbjct: 179 NAIAPGFIESDMTGVLPEKMQEQILSQIPMKRIGKAQEVAHLASFLVEQDYITGQVIAID 238 Query: 258 GGM 260 GGM Sbjct: 239 GGM 241 >BS_fabG [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Bsu Bacillus subtilis Length = 246 Score = 164 bits (414), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 95/245 (38%), Positives = 135/245 (55%), Gaps = 7/245 (2%) Query: 25 LHGHVALVTGGSRGIGAAIVKMLADAGAAVAINYRERSAAAETLAKGITAAGGRAVAIAA 84 L+ A+VTG SRGIG +I LA +GA V +NY A A + I + G +A+A+ A Sbjct: 2 LNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANEVVDEIKSMGRKAIAVKA 61 Query: 85 DVSEAAAVATLVERAESELGPVDILVNNAGIAIVRGVDDLTEEDFDRTITVNLKSAFLCT 144 DVS V +++ S +DILVNNAGI + + E+++D I +NLK F CT Sbjct: 62 DVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMKEDEWDDVININLKGVFNCT 121 Query: 145 QAVLPMMRTRKWGRIVNISSGAARGAGSIGPHYNASKAAMEGMTRGYAARLVKEGITVNA 204 +AV M ++ GRI+N+SS +Y A+KA + G+T+ A L ITVNA Sbjct: 122 KAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAGVIGLTKSSAKELASRNITVNA 181 Query: 205 VAPSLIETDMMRG-----QSELVSRIPMGRFGTAEEVAQAVMLLVNN--PYMTGQTIAMS 257 +AP I TDM Q E++ +IP+ RFG +V+ V L + YMTGQT+ + Sbjct: 182 IAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDVSSVVTFLASEGARYMTGQTLHID 241 Query: 258 GGMAF 262 GGM Sbjct: 242 GGMVM 246