BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0014.0005.p         (308 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

SMb20205 [R] COG1235 Metal-dependent hydrolases of the beta-lact...   253   5e-67
PA1986 [R] COG1235 Metal-dependent hydrolases of the beta-lactam...   191   2e-48

>SMb20205 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase
           superfamily I Sme Sinorhizobium meliloti
          Length = 303

 Score =  253 bits (645), Expect = 5e-67,   Method: Compositional matrix adjust.
 Identities = 141/309 (45%), Positives = 197/309 (63%), Gaps = 14/309 (4%)

Query: 2   LRVVVLGAAAGGGVPQWNCGCAVCRTARSGHPELQ-STQASIAVSGDGVHWFLVNASPDL 60
           LR++VLGAAAGGG+PQWNCGC  C  AR     L+  TQ+S+AVS DG  W + NASPD+
Sbjct: 7   LRIIVLGAAAGGGLPQWNCGCRNCAMARDPASGLRPQTQSSLAVSLDGESWTVFNASPDI 66

Query: 61  RQQLIATPQLHPKHGALRHSPIAGVILTNGEIDAVAGLLSMREGSPFTIYAHERVLAILR 120
           RQQ+     L P+   LRHSPI  V+LTNG+ID +AGLL +RE   FT+++   V  I+ 
Sbjct: 67  RQQVQDNCPLQPRR--LRHSPIESVVLTNGDIDHLAGLLVLREKQAFTLFSTGAVGRIVS 124

Query: 121 SNSIFNVLSDKNVDRRPIAVDQAFEPALPDGSPSGLEVLPFEVPGKGAWYLE-GKAHXGA 179
            N +F VL  + V R+ I +D+AF P       SGL+   F VPGK   +LE G+   G 
Sbjct: 125 DNPVFQVLDPELVSRKTIEIDEAFSPL------SGLDARLFAVPGKVPLFLEDGEPDLGI 178

Query: 180 DGVGDTLGLRIADRRSGKYFYFLAACARVTDDLKVRLKGAPLVFFDGTVWRDDELIAAGL 239
           +G   T+GL +    +G+  Y++  CA +TD L  RL+ A  VFFDGT++ DDE+I  G 
Sbjct: 179 EG-EHTVGLEL--EATGRRVYYVPGCAMMTDSLAARLRDADAVFFDGTLFSDDEMILTGT 235

Query: 240 GNKTGQGMGHIAMSGDQGAIASLAGLDIGRKVFLHINNSNPALLGTSAERKAAEQAGWQI 299
           G KTG+ MGH+ + G+ G++ +L  L+I RK+++HINN+NP +    +ER+  E  G++I
Sbjct: 236 GRKTGRRMGHMPIDGEGGSLDALDLLNIRRKIYVHINNTNP-IWRAGSERERVEARGFEI 294

Query: 300 PADGTEIVL 308
             DG E+ L
Sbjct: 295 GYDGMEVRL 303


>PA1986 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase
           superfamily I Pae Pseudomonas aeruginosa
          Length = 304

 Score =  191 bits (484), Expect = 2e-48,   Method: Compositional matrix adjust.
 Identities = 118/312 (37%), Positives = 164/312 (52%), Gaps = 13/312 (4%)

Query: 2   LRVVVLGAAAGGGVPQWNCGCAVCRTARSGHPELQS-TQASIAVSGDGVHWFLVNASPDL 60
           + + +LG+AAGGG PQWNC C  CR  R G    Q  TQ+SIA+S DG  W L NASPD+
Sbjct: 1   MHIRILGSAAGGGFPQWNCNCRNCRGVRDGSVAAQPRTQSSIALSDDGERWILCNASPDI 60

Query: 61  RQQLIATPQLHPKHGALRHSPIAGVILTNGEIDAVAGLLSMREGSPFTIYAHERVLAILR 120
           R Q+ A P L P     R + I  ++L + +ID   GLLS+REG P  ++  + V   L 
Sbjct: 61  RAQIAAFPALQPARRP-RDTAIGAIVLLDSQIDHTTGLLSLREGCPHEVWCTQMVHQDLS 119

Query: 121 SN-SIFNVLSDKN--VDRRPIAVDQAFEP-ALPDGSPSGLEVLPFEVPGKGAWYLEGKAH 176
               +F +LS  N  +  RPIA+D   EP A+P         +P               H
Sbjct: 120 EGFPLFPMLSHWNGGLRHRPIALDG--EPFAIPACPRLRFTAIPLRSSAPPY-----SPH 172

Query: 177 XGADGVGDTLGLRIADRRSGKYFYFLAACARVTDDLKVRLKGAPLVFFDGTVWRDDELIA 236
            G    GD +GL + D  S    ++      V + L   ++ A  +  DGT+WRDDE++ 
Sbjct: 173 RGDPHPGDNIGLFVEDLDSAGALFYAPGLGEVDEALLEWMRRADCLLVDGTLWRDDEMLV 232

Query: 237 AGLGNKTGQGMGHIAMSGDQGAIASLAGLDIGRKVFLHINNSNPALLGTSAERKAAEQAG 296
             +G+K G+ MGH+A SG  G +  LA +   RKV +HINN+NP L   SAER   + +G
Sbjct: 233 CEVGDKLGRQMGHLAQSGPGGMLEVLAKVPAARKVLIHINNTNPILDTASAERAELDASG 292

Query: 297 WQIPADGTEIVL 308
            ++  DG  I L
Sbjct: 293 IEVAWDGMHIQL 304