BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0032.p (300 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH0390 [GER] COG0697 Permeases of the drug/metabolite transporte... 83 8e-16 AF0266 [GER] COG0697 Permeases of the drug/metabolite transporte... 77 5e-14 AF0510 [GER] COG0697 Permeases of the drug/metabolite transporte... 66 1e-10 TM1017 [GER] COG0697 Permeases of the drug/metabolite transporte... 63 9e-10 BS_yetK [GER] COG0697 Permeases of the drug/metabolite transport... 62 2e-09 >BH0390 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bha Bacillus halodurans Length = 311 Score = 82.8 bits (203), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 78/292 (26%), Positives = 129/292 (44%), Gaps = 14/292 (4%) Query: 18 GTSIGATRFLVGAIDPLAIGAFRFGIGVLLLLPLALLQRRSWPTRHDWLGVAGLGLLFFA 77 G+S+ A + LV + RF I L+L+P+ LL++ PT +G+LF Sbjct: 19 GSSVVAGKMLVESFPVFLASELRFLIAALILVPM-LLKKEGIPTFSK----KEVGILFLQ 73 Query: 78 A------FPVLFNASLIFTTAARGALALSTLPLLTMLVGAALGAEALTARKTAGVLITIL 131 A F + L++TTA G + +STLP + L+ E LT G+L+ + Sbjct: 74 ALSGVFLFSIFMLYGLMYTTAMEGGIIMSTLPAVVALMAFITLKEKLTRLTIIGILLAVG 133 Query: 132 GVSMALLSG-LATAPPGA--WRGDLLMIAAALCMALYSIWSKPYIRRSGPIPFTTLAMAA 188 G SG L+ G G+LL+I A + AL+ I+ K +R P+ +T+ Sbjct: 134 GTLAINTSGTLSDVERGVAPLLGNLLIIGAVISEALFIIFGKSISQRVSPLAISTMVSVF 193 Query: 189 GAVVLITASLLRGSFAPVADFGAPQWFGAIYLGAFGAALTFYLWAFALERTTPTRVAISV 248 G V+ + ++ + P+ D W Y G + F L +E+ + V + Sbjct: 194 GVVLFLPFAIYEATRFPLTDVSLNDWLIIFYFGVVVTVIAFVLMYQGIEKVPASTVGVLT 253 Query: 249 TVNPIAASLVGAALLSEPLSWNLVAGIVTVFAGIWIATTQPPLAHAVAPDMR 300 V PI+A L+ A +L E S VAG+ V A I + + + ++ Sbjct: 254 GVLPISAVLLSALILKESFSTFHVAGMGLVLAAILLISIDSNVEKKEVASLK 305 >AF0266 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Afu Archaeoglobus fulgidus Length = 276 Score = 77.0 bits (188), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 69/273 (25%), Positives = 126/273 (46%), Gaps = 14/273 (5%) Query: 18 GTSIGATRFLVGAIDPLAIGAFRFGIGVLLLLPLALLQRR-SWPTRHDWLGVAGLGLLFF 76 G + A ++ V + P+AI + RF I L + +L +R W D V LG+ Sbjct: 15 GLAFTAIKYSVRFLSPIAIASLRFAIANTLFAVIIILGKRIKW---KDLPKVFALGIFGV 71 Query: 77 AAFPVLFNASLIFTTAARGALALSTLPLLTMLVGAALGAEALTARKTAGVLITILGVSMA 136 + + V N ++ ++ ++ +S P+ +++ A E +T K G++I LGV + Sbjct: 72 SVYHVFLNLGEVYISSGVASVVISLAPIFVLILSAIFLRERITYSKVVGIIIAFLGVVV- 130 Query: 137 LLSGLATAPPGAWRGDLLMIAAALCMALYSIWSKPYIRRSGPIPFTTLAMAAGAVVLITA 196 ++ G L++ + + A+Y+ + K + + PI T+ AM G++ L Sbjct: 131 ----ISEPSYANIYGIALVMVSTVAAAIYTTFGKSLLSKYNPITLTSNAMVLGSIPL--Y 184 Query: 197 SLLRGSFAPVADFGAPQWFGAI-YLGAFGAALTFYLWAFALERTTPTRVAISVTVNPIAA 255 L S + G G+I +LG F + W + LE+ +R ++ + P+ + Sbjct: 185 PFLPDSIRSLG--GDLNLIGSIVFLGIFSTFFGYLGWYYFLEKEEASRASVFLLAIPVVS 242 Query: 256 SLVGAALLSEPLSWNLVAGIVTVFAGIWIATTQ 288 L G LL+EPL+ VAG V GI+I + Sbjct: 243 LLAGNILLAEPLTLRTVAGSGLVLLGIYIVVRK 275 >AF0510 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Afu Archaeoglobus fulgidus Length = 289 Score = 65.9 bits (159), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 122/265 (46%), Gaps = 13/265 (4%) Query: 31 IDPLAIGAFRFGIGVLLLLPLALLQR-RSWPTRHDWLGVAGL---GLLFFAAFPVLFNAS 86 +DP + +RF + LL+ +R + P+ +WL ++ L G+ AF L + Sbjct: 30 LDPFNLAFYRFLLASPLLMAWVFWKRGLAKPSGSEWLHLSVLALSGVTLLYAFQFL---A 86 Query: 87 LIFTTAARGALALSTLPLLTMLVGAALGAEALTARKTAGVLITILGVSMALLSG-LATAP 145 L +TTA ++ ++T + L G G EA RK AGV ++ GV + + G L Sbjct: 87 LKYTTATNASILINTSAVFVALWGLVKG-EA-NPRKLAGVFLSFAGVVLIVSKGTLEFFS 144 Query: 146 PGAWRGDLLMIAAALCMALYSIWSKPYIRRSGPIPFTTLAMAAGAVVLITASLLRGSFAP 205 GD+LMI A+Y++ + + T A A G + LI +L+ G FA Sbjct: 145 SKTIFGDVLMIVDGFLWAVYTVLGSKMLLKYDHETLTAYAFALGTIFLIPFALMSG-FAN 203 Query: 206 VADFGAPQWFGAIYLGAFGAALTFYLWAFALERTTPTRVAISVTVNPIAASLVGAALLSE 265 F +YL + + +W +AL T VA+ V + P+ ++ L+E Sbjct: 204 PVTFNPETVAALLYLSILCSVFAYVVWYYALTNADSTSVAVYVYLVPLFTAIFAFYALNE 263 Query: 266 -PLSWNLVAGIVTVFAGIWIATTQP 289 P + + GI+T+ AG+++ T + Sbjct: 264 KPDFFTAIGGIITI-AGVYLTTAKQ 287 >TM1017 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Tma Thermotoga maritima Length = 293 Score = 62.8 bits (151), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 71/277 (25%), Positives = 117/277 (42%), Gaps = 22/277 (7%) Query: 7 VLAAVASSALGGTSIGATRFLVGAIDPLAIGAFRFGI---GVLLLLPLALLQRRSWPTRH 63 +L+ +A S + G S T+ + + PL +FRF + LLLL ++ P Sbjct: 6 LLSGLAYSTIFGLSFLFTKNALDYVTPLTFLSFRFIVAFLSYLLLLITGAVKLGKKPYWK 65 Query: 64 DWLGVAGLGLLFFAAFPVLFNASLIFTTAARGALALSTLPLLTMLVGAALGAEALTARKT 123 W L+ F PVL+ +F T + S ++ L+ + A K Sbjct: 66 LW------KLVLFQ--PVLY---FLFETYGLQRVNSSEAGMIIALIPIVVNLLAPFILKE 114 Query: 124 AGVLITILGVSMALLSGLA-----TAPPGAWRGDLLMIAAALCMALYSIWSKPYIRRSGP 178 G L+ L V M L G++ PG G + M+ A L A+YS++S+ + + P Sbjct: 115 KGDLLHYLLVGMGFL-GVSLIVGFNITPGNIVGKVFMLLAVLSGAMYSVFSRKFSKEFTP 173 Query: 179 IPFTTLAMAAGAVVLITASLLRGSFAPVADFGAPQWFGAIYLGAFGAALTFYLWAFALER 238 T M GAV SL G F PV F GA+YLG + + F+L +A+ + Sbjct: 174 TEITFFMMMTGAVFFTLLSLSTGDFRPV--FNVDVVIGALYLGVLSSTVAFFLLNYAIRK 231 Query: 239 TTPTRVAISVTVNPIAASLVGAALLSEPLSWNLVAGI 275 +P + + + + G +E + +AG+ Sbjct: 232 LSPIFTTLFSNFTTVVSVIAGVVFRNETVGIQQIAGM 268 >BS_yetK [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bsu Bacillus subtilis Length = 330 Score = 61.6 bits (148), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 127/298 (42%), Gaps = 16/298 (5%) Query: 12 ASSALGGTSIGATRFLVGAIDPLAIGAFRFGIGVLLLLPLALLQRRSWP--TRHDW--LG 67 A+ A+ G+S+ + +V I RF I ++LL L + +P T+ D L Sbjct: 35 AAMAIVGSSVVVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLL 94 Query: 68 VAGLGLLFFAAFPVLFNASLIFTTAARGALALSTLPLLTMLVGAALGAEALTARKTAGVL 127 V +F + +L+ +TT + ST P+L ++ L E + + G+L Sbjct: 95 VQSFTGVFLFSICLLYGVQ--YTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGIL 152 Query: 128 ITILGVSMALL--SGLATAPPGAWRGDLLMIAAALCMALYSIWSKPYIRRSGPIPFTTLA 185 + + GV L +G P A G++L+IAA + AL+++ +K + +T Sbjct: 153 LAVCGVMAINLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFV 212 Query: 186 MAAGAVVLITASLLRGSFAPVADFGAP---QWFGAIYLGAFGAALTFYLWAFALERTTPT 242 G + + +L S D+ P W +Y F L FYLW + + Sbjct: 213 SLFGFLFFLPFALFEAS---SFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAG 269 Query: 243 RVAISVTVNPIAASLVGAALLSEPLSWNLVAGIVTVFAGIWIA--TTQPPLAHAVAPD 298 I +V P++A ++ +L EP + GI V GI++ + P A+ A + Sbjct: 270 VSGIFTSVLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEE 327