BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0010.0009.p         (119 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

MA1946 [R] COG1237 Metal-dependent hydrolases of the beta-lactam...    90   1e-18
PH0874 [R] COG1237 Metal-dependent hydrolases of the beta-lactam...    70   2e-12
PAB0518 [R] COG1237 Metal-dependent hydrolases of the beta-lacta...    69   4e-12
MA1962 [R] COG1237 Metal-dependent hydrolases of the beta-lactam...    63   2e-10
MJ0301 [R] COG1237 Metal-dependent hydrolases of the beta-lactam...    63   2e-10

>MA1946 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Mac Methanosarcina acetivorans str.C2A
          Length = 320

 Score = 89.7 bits (221), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 40/119 (33%), Positives = 72/119 (60%), Gaps = 1/119 (0%)

Query: 1   MDGKIVPDEHIHEHATCFNVRDFGLVVISSCGHVGIVNSVKQAQEVSGIQKVHAIVGGFH 60
           +DGK + D  + +      ++  GLVVIS C H GI+N+V+ A++++G  KVHA++GGFH
Sbjct: 199 VDGKWLTDPFLDDQGLVIKLKGKGLVVISGCAHAGIINTVEYAKKMAGTDKVHAVLGGFH 258

Query: 61  L-GPAPKDYLTEVVAEIRKLDPDVLIPMHCSGLNFVQEATAQMGDKVLVTTTGSRLSFG 118
           L G      +   + E++++ PD ++PMHC+G   +     +M ++ ++ + G+   FG
Sbjct: 259 LTGRLFDPIIQPTIDEMKRISPDHIVPMHCTGWKAINRFAEEMPEQFILNSVGTTYVFG 317


>PH0874 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Pho Pyrococcus horikoshii
          Length = 280

 Score = 69.7 bits (169), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 37/104 (35%), Positives = 60/104 (57%), Gaps = 1/104 (0%)

Query: 2   DGKIVPDEHIHEHATCFNVRDFGLVVISSCGHVGIVNSVKQAQEVSGIQKVHAIVGGFHL 61
           DG+++ D+   E     N R  GLVV++ C H GIV+ VK+A ++SG  KV+A++GGFHL
Sbjct: 165 DGRVIEDKVEDEIGLAINTRK-GLVVLAGCAHPGIVSMVKKAIKLSGNDKVYAVLGGFHL 223

Query: 62  GPAPKDYLTEVVAEIRKLDPDVLIPMHCSGLNFVQEATAQMGDK 105
             A    + + V   ++L+   +   HC+GL        ++GD+
Sbjct: 224 INAEDSRIEKTVEAFKELEVKKVYAGHCTGLKAESRFAQELGDR 267


>PAB0518 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Pab Pyrococcus abyssi
          Length = 272

 Score = 68.6 bits (166), Expect = 4e-12,   Method: Compositional matrix adjust.
 Identities = 33/69 (47%), Positives = 47/69 (68%), Gaps = 1/69 (1%)

Query: 24  GLVVISSCGHVGIVNSVKQAQEVSGIQKVHAIVGGFHLGPAPKDYLTEVVAEIRKLDPDV 83
           GLVVIS CGH GI+N  + A E+ G  K+ A++GGFHL  A K+ L +VV  +++L  + 
Sbjct: 181 GLVVISGCGHSGIINIARHAMELRG-SKIAALIGGFHLRGAKKELLDDVVTNMKELGVNA 239

Query: 84  LIPMHCSGL 92
           L P HC+G+
Sbjct: 240 LYPGHCTGI 248


>MA1962 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Mac Methanosarcina acetivorans str.C2A
          Length = 280

 Score = 62.8 bits (151), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 34/93 (36%), Positives = 52/93 (55%), Gaps = 1/93 (1%)

Query: 1   MDGKIVPDEHIHEHATCFNVRDFGLVVISSCGHVGIVNSVKQAQEVSGIQKVHAIVGGFH 60
           + G  +PD    + A  +   + GLV+I+ C H GI N  + A+EV G  +V  IVGGFH
Sbjct: 166 IKGNKIPDLLPDDTALVYRA-ETGLVIITGCSHSGICNITEYAKEVCGDSRVLDIVGGFH 224

Query: 61  LGPAPKDYLTEVVAEIRKLDPDVLIPMHCSGLN 93
           L    K+ +   +  ++KLDP+ +   HC+ LN
Sbjct: 225 LLEPSKERMRGTLDYLKKLDPECIHACHCTDLN 257


>MJ0301 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase
           superfamily II Mja Methanococcus jannaschii
          Length = 294

 Score = 62.8 bits (151), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 31/91 (34%), Positives = 56/91 (61%), Gaps = 1/91 (1%)

Query: 2   DGKIVPDEHIHEHATCFNVRDFGLVVISSCGHVGIVNSVKQAQEVSGIQKVHAIVGGFHL 61
           +G++V D ++ +      V + GL+++S C H GIV+ VK++ ++SGI KV+A++GGFHL
Sbjct: 180 NGRVVLD-NVEDEIGLAIVTEKGLIIVSGCSHPGIVSMVKKSIKISGINKVYAVIGGFHL 238

Query: 62  GPAPKDYLTEVVAEIRKLDPDVLIPMHCSGL 92
             A  + +   +  ++KL    +   HC+G 
Sbjct: 239 IDADNERIVSTIKALKKLGVKKICTGHCTGF 269