BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0007.p (700 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SA0102 [S] COG4716 Myosin-crossreactive antigen Sau Staphylococc... 457 e-128 SPy0470 [S] COG4716 Myosin-crossreactive antigen Spy Streptococc... 457 e-128 L180241 [S] COG4716 Myosin-crossreactive antigen Lla Lactococcus... 435 e-121 lin0483 Non COG 372 e-102 >SA0102 [S] COG4716 Myosin-crossreactive antigen Sau Staphylococcus aureus N315 Length = 591 Score = 457 bits (1176), Expect = e-128, Method: Compositional matrix adjust. Identities = 233/550 (42%), Positives = 333/550 (60%), Gaps = 16/550 (2%) Query: 43 RPVSKQPVEARKAWIIGSGIAGLAAAFYMIRDGGMKGDDITILDTMHIEGGSLDGARDPE 102 RP + VE + A++IGSG+A LAAA ++IRDG M+G I IL+ + GGSLDG P Sbjct: 13 RPKKPENVENKSAYLIGSGLASLAAACFLIRDGQMEGSKIHILEELPKAGGSLDGENMPL 72 Query: 103 NGYIIRGGREMNWNYDNLWDMFQDVQALELPEGYSVLDEYRLVNDNDPNFSKARLMHKRG 162 GY++RGGREM +++ LWD+F+ + +LE+ + SVLDE+ +N DPN+S+ R++ K+G Sbjct: 73 KGYVVRGGREMENHFECLWDLFRSIPSLEI-DNASVLDEFYWLNKEDPNYSRCRVIEKQG 131 Query: 163 Q--IRDFSTLGLSKPQQWELIRLLLKRKEDLDDITIEQYFSPGFLETNFWFLWRSMFAFE 220 Q + D L+K E++ L L +EDLDD+ I FS F +NFW W++MFAFE Sbjct: 132 QRLVTD-GDFTLTKTAIKEILDLCLTNEEDLDDVKITDVFSDDFFNSNFWIYWKTMFAFE 190 Query: 221 NWQSLLEMKLYMHRFLDAIDGLTDMSALVFPKYNQFDSFVRPLVTHLRERGVKVQFDTRV 280 W S +EM+ Y+ RF+ I GL D SAL F KYNQ++S V P+V +L+ GV+ ++D +V Sbjct: 191 PWHSAMEMRRYLMRFVHHIGGLADFSALKFTKYNQYESLVLPMVEYLKSHGVQFEYDVKV 250 Query: 281 HDLDIKTDGDARTVTAIHAKVGGADTTIPVGPKDLVFALTGSMTEGTAYGDMD--HAPVL 338 D+ + + I G +I + DLVF GS+TE + YGD D P Sbjct: 251 EDIKVDVTTSQKIAREILIHRHGKAESIKLTVDDLVFVTNGSITESSTYGDNDTPAPPTD 310 Query: 339 QRGKHDPGQASDWTLWTNLAKKSPIFGKPEKFYGNVDKSMW-ESVTLTCKPSPFVDRLKE 397 + G WTLW NLA++SP FG P+KF N+ K W S T T +D ++ Sbjct: 311 ELG-------GSWTLWKNLARQSPEFGNPDKFCQNIPKKSWFVSATSTTNNKEIIDTIES 363 Query: 398 LSVNDPYSGKTVTGGIITFTDSNWVLSFTCNRQPHFPTQPKDVLVVWVYALLMDKEGNYI 457 + DP +GKTVTGGIIT DS W +SFT NRQ F QP++ + W+YAL D G+YI Sbjct: 364 ICKRDPLAGKTVTGGIITINDSAWQMSFTINRQQQFKDQPENEISTWIYALYSDVNGDYI 423 Query: 458 KKPMPACTGRQILAELCYHLGIE-DKLDAVVANTKARLAL-MPYITAMFMPRAAGDRPHP 515 KKP+ C+G +I E YHLG+ DK++ + + + + MPYIT+ FM RA GDRP Sbjct: 424 KKPITECSGNEICQEWLYHLGVSTDKIEDLAKHVSNTIPVYMPYITSYFMTRAIGDRPLV 483 Query: 516 VPAGCTNLGLMGQFVETSNDIIFTMDSSVRTARVAVYTLLKLAKQVPDISPTQYDIRTIL 575 VP NL +G F ET D +FT + SVRTA AVY LL + + +P++ + +D+R ++ Sbjct: 484 VPHQSQNLSFIGNFAETERDTVFTTEYSVRTAMEAVYQLLNIDRGIPEVINSTFDLRVLM 543 Query: 576 KGARALNNNE 585 LN+++ Sbjct: 544 DAVYELNDHQ 553 >SPy0470 [S] COG4716 Myosin-crossreactive antigen Spy Streptococcus pyogenes M1 GAS Length = 590 Score = 457 bits (1176), Expect = e-128, Method: Compositional matrix adjust. Identities = 239/576 (41%), Positives = 345/576 (59%), Gaps = 28/576 (4%) Query: 44 PVSKQPVEARKAWIIGSGIAGLAAAFYMIRDGGMKGDDITILDTMHIEGGSLDGARDPEN 103 P + V+ + A+I+G+G+AGLAAA ++IRDG M G+ I + + + + GGSLDG P Sbjct: 14 PRKPEGVDQKSAYIVGTGLAGLAAAVFLIRDGHMAGERIHLFEELPLAGGSLDGIEKPHL 73 Query: 104 GYIIRGGREMNWNYDNLWDMFQDVQALELPEGYSVLDEYRLVNDNDPNFSKARLMHKRG- 162 G++ RGGREM +++ +WDM++ + +LE+P G S LDE+ ++ +DPN S RL+HKRG Sbjct: 74 GFVTRGGREMENHFECMWDMYRSIPSLEIP-GASYLDEFYWLDKDDPNSSNCRLIHKRGN 132 Query: 163 QIRDFSTLGLSKPQQWELIRLLLKRKEDLDDITIEQYFSPGFLETNFWFLWRSMFAFENW 222 ++ D L K Q ELI L++K +E L D TIE++FS F ++NFW W +MFAFE W Sbjct: 133 RVDDDGQYTLGK-QSKELIHLIMKTEESLGDQTIEEFFSEDFFKSNFWVYWATMFAFEKW 191 Query: 223 QSLLEMKLYMHRFLDAIDGLTDMSALVFPKYNQFDSFVRPLVTHLRERGVKVQFDTRVHD 282 S +EM+ Y RF+ IDGL D ++L F KYNQ+DS V+P++ +L V +QFDT+V D Sbjct: 192 HSAVEMRRYAMRFIHHIDGLPDFTSLKFNKYNQYDSMVKPIIAYLESHDVDIQFDTKVTD 251 Query: 283 LDIKTDGDARTVTAIHAKVGGADTTIPVGPKDLVFALTGSMTEGTAYGDMDHAPVLQRGK 342 + ++ + IH V G I + P DLVF GS+TE + YG H V + K Sbjct: 252 IQVEQTAGKKVAKTIHMTVSGEAKAIELTPDDLVFVTNGSITESSTYG--SHHEVAKPTK 309 Query: 343 HDPGQASDWTLWTNLAKKSPIFGKPEKFYGNVDKSMW-ESVTLTCKP---SPFVDRLKEL 398 G W LW NLA +S FG P+ FY ++ W S T T K P+++RL Sbjct: 310 ALGGS---WNLWENLAAQSDDFGHPKVFYQDLPAESWFVSATATIKHPAIEPYIERLTHR 366 Query: 399 SVNDPYSGKTVTGGIITFTDSNWVLSFTCNRQPHFPTQPKDVLVVWVYALLMDKEGNYIK 458 ++D GK TGGIIT TDSNW++SF +RQPHF Q ++ VW+Y L + EGNY+ Sbjct: 367 DLHD---GKVNTGGIITITDSNWMMSFAIHRQPHFKEQKENETTVWIYGLYSNSEGNYVH 423 Query: 459 KPMPACTGRQILAELCYHLGIE-DKLDAVVANTKARL--ALMPYITAMFMPRAAGDRPHP 515 K + CTG++I E YHLG+ DK+ + + MPYIT+ FMPR GDRP Sbjct: 424 KKIEECTGQEITEEWLYHLGVPVDKIKDLASQDYINTVPVYMPYITSYFMPRVKGDRPKV 483 Query: 516 VPAGCTNLGLMGQFVET-SNDIIFTMDSSVRTARVAVYTLLKLAKQVPDISPTQYDIRTI 574 +P G NL +G F E+ S D +FT + S+RTA AVY+ L + + +P++ + YDIR + Sbjct: 484 IPDGSVNLAFIGNFAESPSRDTVFTTEYSIRTAMEAVYSFLNVERGIPEVFNSAYDIREL 543 Query: 575 LKGARALNNNE-------PFPG--ERLLHRLLDKTY 601 LK LN+ + P P E++ H+ + T+ Sbjct: 544 LKAFYYLNDKKAIKDMDLPIPALIEKIGHKKIKDTF 579 >L180241 [S] COG4716 Myosin-crossreactive antigen Lla Lactococcus lactis Length = 587 Score = 435 bits (1119), Expect = e-121, Method: Compositional matrix adjust. Identities = 229/547 (41%), Positives = 329/547 (60%), Gaps = 13/547 (2%) Query: 43 RPVSKQPVEARKAWIIGSGIAGLAAAFYMIRDGGMKGDDITILDTMHIEGGSLDGARDPE 102 P + V+ + A+IIG+G+AGLA A ++IRDG M GD I IL+ + + GGSLDG+ P Sbjct: 13 HPRKPENVDQKSAYIIGAGLAGLATAVFLIRDGQMSGDRIHILEELPLSGGSLDGSFIPH 72 Query: 103 NGYIIRGGREMNWNYDNLWDMFQDVQALELPEGYSVLDEYRLVNDNDPNFSKARLMHKRG 162 +G+++RGGREM +++ LWD+F+ + +LE+ + S+LDE+ ++ +DPN S R++H RG Sbjct: 73 DGFVVRGGREMENHFECLWDLFRTIPSLEVDDA-SILDEFYRIDRDDPNSSNCRIIHNRG 131 Query: 163 Q-IRDFSTLGLSKPQQWELIRLLLKRKEDLDDITIEQYFSPGFLETNFWFLWRSMFAFEN 221 + + D LS Q E+I+L + ++E L TIE F+ F ++NFW W SMFAFE Sbjct: 132 ERVDDDGKFTLSPKAQEEIIKLFMTKEELLVGKTIEDCFTDEFFKSNFWLYWCSMFAFEK 191 Query: 222 WQSLLEMKLYMHRFLDAIDGLTDMSALVFPKYNQFDSFVRPLVTHLRERGVKVQFDTRVH 281 W S +EM+ Y+ RF+ I+GL D SAL F KYNQ++S V+PL+++L++ GV ++ +V Sbjct: 192 WHSAIEMRRYIMRFIHHIEGLPDFSALKFTKYNQYESLVKPLISYLKDHGVDFKYGAQVE 251 Query: 282 DLDIKTDGDARTVTAIHAKVGGADTTIPVGPKDLVFALTGSMTEGTAYGDMDHAPVLQRG 341 ++++ + AI V + DLVF GS+TE + G +P Q Sbjct: 252 NVEVDFSNGKKVAKAI---VFADKEIKELTENDLVFVTNGSITESSTQG----SPT-QAA 303 Query: 342 KHDPGQASDWTLWTNLAKKSPIFGKPEKFYGNVDKSMW-ESVTLTCKPSPFVDRLKELSV 400 W LW NLAK+S FG P+ F + K W S T+T K ++L+ Sbjct: 304 PKTSELGGSWKLWQNLAKQSEEFGHPDVFCKEIPKEAWVVSATVTWKNLKIQPYFEKLTH 363 Query: 401 NDPYSGKTVTGGIITFTDSNWVLSFTCNRQPHFPTQPKDVLVVWVYALLMDKEGNYIKKP 460 SGK +TGGIIT DSNW+LSFT +RQPHF Q V WVY LL + GNYIKKP Sbjct: 364 RQLRSGKVITGGIITVKDSNWLLSFTTHRQPHFKEQNDQETVTWVYGLLSNTPGNYIKKP 423 Query: 461 MPACTGRQILAELCYHLGI-EDKLDAVV-ANTKARLALMPYITAMFMPRAAGDRPHPVPA 518 + CTG +I EL YHLG+ E++++A V NT MP+IT+ FM R GDRP VP Sbjct: 424 IEDCTGEEITQELLYHLGMPEEEIEAFVKENTNTIPVYMPFITSYFMLREPGDRPLVVPE 483 Query: 519 GCTNLGLMGQFVETSNDIIFTMDSSVRTARVAVYTLLKLAKQVPDISPTQYDIRTILKGA 578 NL +G F ET D +FT + SVRTA AVY LL + + VP++ + YD+RT+ A Sbjct: 484 QSVNLAFLGNFAETERDTVFTTEYSVRTAMEAVYQLLNVDRGVPEVYASAYDLRTLASSA 543 Query: 579 RALNNNE 585 L++ + Sbjct: 544 YYLSDKQ 550 >lin0483 Non COG Length = 566 Score = 372 bits (955), Expect = e-102, Method: Compositional matrix adjust. Identities = 195/531 (36%), Positives = 296/531 (55%), Gaps = 17/531 (3%) Query: 53 RKAWIIGSGIAGLAAAFYMIRDGGMKGDDITILDTMHIEGGSLDGARDPENGYIIRGGRE 112 ++ + +G GIA LA A Y+IRD G +I I++ MHI GGS DGA E+G++ RGGR Sbjct: 49 KQVYFVGGGIASLAGAVYLIRDANFDGKNIHIIEGMHILGGSNDGAGSVEHGFVCRGGRM 108 Query: 113 MNWN-YDNLWDMFQDVQALELPEGYSVLDEYRLVNDNDPNFSKARLMHKRGQIRDFSTLG 171 +N Y+N WD+F + +L++P +SV +E + P ++ARL+ K I D ++G Sbjct: 109 LNEETYENFWDLFSSIPSLDMP-NFSVTEEILNFDHLHPTHAQARLVDKDRNILDAHSMG 167 Query: 172 LSKPQQWELIRLLLKRKEDLDDITIEQYFSPGFLETNFWFLWRSMFAFENWQSLLEMKLY 231 + + + +LL +E LD++TI +F F ETNFW++W++ FAF+ W SL E + Y Sbjct: 168 FNNNDRMLMTKLLATPEEKLDNLTIRDWFDEHFFETNFWYMWQTTFAFQKWSSLFEFRRY 227 Query: 232 MHRFLDAIDGLTDMSALVFPKYNQFDSFVRPLVTHLRERGVKVQFDTRVHDLDIKTDGDA 291 M+R + + + + NQ++S + PL T L + V + V D+D K D Sbjct: 228 MNRMMLEFSRIDTLEGVTRTPLNQYESLILPLKTFLDKHHVDFTINQTVEDIDFK-DAPG 286 Query: 292 RTVTAIHAKVGGADTTIPVGPKDLVFALTGSMTEGTAYGDMDHAPVLQRGKHDPGQASDW 351 T TA+H G +TI +GP D V MT+ GDM+ K G+ Sbjct: 287 ITATALHLSDG---STIELGPDDDVIMTNACMTDSATLGDMNTPAPKPEEKPISGE---- 339 Query: 352 TLWTNLAKKSPIFGKPEKFYGNVDKSMWESVTLTCKPSPFVDRLKELSVNDPYSGKTVTG 411 LW +A+K P G PE F+G+ +++ W+S T+TC + R++ + N P S G Sbjct: 340 -LWYKVAQKKPNLGNPEPFFGHEEETNWQSFTVTCHGDKLLKRIERFTGNIPGS-----G 393 Query: 412 GIITFTDSNWVLSFTCNRQPHFPTQPKDVLVVWVYALLMDKEGNYIKKPMPACTGRQILA 471 ++TF DSNW++S QPHF Q + + W Y L D+ G+++KKPM CTG +IL Sbjct: 394 ALMTFKDSNWLMSTVVAAQPHFKAQDANTTIFWGYGLYPDRVGDFVKKPMKECTGEEILY 453 Query: 472 ELCYHLGIEDKLDAVVANTKARL-ALMPYITAMFMPRAAGDRPHPVPAGCTNLGLMGQFV 530 EL HL +D + + A+ + MPYI A F PRA DRP VP G TN ++ QFV Sbjct: 454 ELMCHLNWQDDFEEIKADIINVIPCYMPYIDAQFEPRAMSDRPAVVPEGSTNFAMISQFV 513 Query: 531 ETSNDIIFTMDSSVRTARVAVYTLLKLAKQVPDISPTQYDIRTILKGARAL 581 E D++FT + SVR AR+AVYTLL + K++ ++P D + + K + + Sbjct: 514 EIPKDMVFTEEYSVRAARIAVYTLLDIDKKICPVTPHNRDPKVLAKATQTM 564