BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0007.0006.p         (264 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

MT1951_2 [T] COG2114 Adenylate cyclase, family 3 (some proteins ...   154   1e-37
Rv1900c_2 [T] COG2114 Adenylate cyclase, family 3 (some proteins...   154   1e-37
Rv1647 [T] COG2114 Adenylate cyclase, family 3 (some proteins co...    70   6e-12
MT1685 [T] COG2114 Adenylate cyclase, family 3 (some proteins co...    70   6e-12
ML1399 [T] COG2114 Adenylate cyclase, family 3 (some proteins co...    66   8e-11

>MT1951_2 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP
           domain) MtC Mycobacterium tuberculosis CDC1551
          Length = 176

 Score =  154 bits (390), Expect = 1e-37,   Method: Compositional matrix adjust.
 Identities = 79/159 (49%), Positives = 110/159 (69%), Gaps = 4/159 (2%)

Query: 105 KQALATILYVDIVRSTEKAARLGDTRWATVMNHYYVAVRRELKALRGKEVVTTGDGVLAT 164
           ++ LATI++ DIV ST+ AA LGD RW  +++++   V  E++   G+EV T GDG +AT
Sbjct: 6   ERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGREVNTAGDGFVAT 65

Query: 165 FRAPAAGIRCATAIRESVRTLGLEIRVGLHAGEYQV----SGAEVIGLAFHIGARVAAKA 220
           F +P+A I CA  I ++V  LG+E+R+G+HAGE +V     G +V G+A HIGARV A A
Sbjct: 66  FTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALA 125

Query: 221 RAGEVLVSSAVKDLMSKSEIRFKDRGAHQLKGVPERWRL 259
              EVLVSS V+D+++ S  RF +RG  +LKGVP RWRL
Sbjct: 126 GPSEVLVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRL 164


>Rv1900c_2 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP
           domain) Mtu Mycobacterium tuberculosis H37Rv
          Length = 176

 Score =  154 bits (390), Expect = 1e-37,   Method: Compositional matrix adjust.
 Identities = 79/159 (49%), Positives = 110/159 (69%), Gaps = 4/159 (2%)

Query: 105 KQALATILYVDIVRSTEKAARLGDTRWATVMNHYYVAVRRELKALRGKEVVTTGDGVLAT 164
           ++ LATI++ DIV ST+ AA LGD RW  +++++   V  E++   G+EV T GDG +AT
Sbjct: 6   ERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGREVNTAGDGFVAT 65

Query: 165 FRAPAAGIRCATAIRESVRTLGLEIRVGLHAGEYQV----SGAEVIGLAFHIGARVAAKA 220
           F +P+A I CA  I ++V  LG+E+R+G+HAGE +V     G +V G+A HIGARV A A
Sbjct: 66  FTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALA 125

Query: 221 RAGEVLVSSAVKDLMSKSEIRFKDRGAHQLKGVPERWRL 259
              EVLVSS V+D+++ S  RF +RG  +LKGVP RWRL
Sbjct: 126 GPSEVLVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRL 164


>Rv1647 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP
           domain) Mtu Mycobacterium tuberculosis H37Rv
          Length = 316

 Score = 69.7 bits (169), Expect = 6e-12,   Method: Compositional matrix adjust.
 Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 14/168 (8%)

Query: 110 TILYVDIVRSTEKAARLGDTRWATVMNHYYVAVRRELKALRGKEVVTTGDGVLATFRAPA 169
           T+++ D+V  +  +   GD    T++     AV   L    G  V   GDG++A FR P 
Sbjct: 130 TLVFTDLVGFSTWSLHAGDDATLTLLRQVARAVESPLLDAGGHIVKRLGDGIMAVFRNPT 189

Query: 170 AGIRCATAIRESVRTLGLE-----IRVGLHAGEYQVSGAEVIGLAFHIGARVAAKARAGE 224
             +R     +++V++L ++     +R+G+H G  Q   A+ +G+  +I ARV  +A  G 
Sbjct: 190 VALRAVLVAQDAVKSLEVQGYTPRMRIGIHTGRPQRLAADWLGVDVNIAARVMERATKGG 249

Query: 225 VLVSSAVKDLMSKSEIRF---------KDRGAHQLKGVPERWRLYRVE 263
           +++S    DL+ +SE+           K   A +  G+P    +YR++
Sbjct: 250 IMISQPTLDLIPQSELDALGVVARRVRKPVFASKPTGIPPDLAIYRIK 297


>MT1685 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP
           domain) MtC Mycobacterium tuberculosis CDC1551
          Length = 327

 Score = 69.7 bits (169), Expect = 6e-12,   Method: Compositional matrix adjust.
 Identities = 45/168 (26%), Positives = 82/168 (48%), Gaps = 14/168 (8%)

Query: 110 TILYVDIVRSTEKAARLGDTRWATVMNHYYVAVRRELKALRGKEVVTTGDGVLATFRAPA 169
           T+++ D+V  +  +   GD    T++     AV   L    G  V   GDG++A FR P 
Sbjct: 141 TLVFTDLVGFSTWSLHAGDDATLTLLRQVARAVESPLLDAGGHIVKRLGDGIMAVFRNPT 200

Query: 170 AGIRCATAIRESVRTLGLE-----IRVGLHAGEYQVSGAEVIGLAFHIGARVAAKARAGE 224
             +R     +++V++L ++     +R+G+H G  Q   A+ +G+  +I ARV  +A  G 
Sbjct: 201 VALRAVLVAQDAVKSLEVQGYTPRMRIGIHTGRPQRLAADWLGVDVNIAARVMERATKGG 260

Query: 225 VLVSSAVKDLMSKSEIRF---------KDRGAHQLKGVPERWRLYRVE 263
           +++S    DL+ +SE+           K   A +  G+P    +YR++
Sbjct: 261 IMISQPTLDLIPQSELDALGVVARRVRKPVFASKPTGIPPDLAIYRIK 308


>ML1399 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP
           domain) Mle Mycobacterium leprae
          Length = 324

 Score = 65.9 bits (159), Expect = 8e-11,   Method: Compositional matrix adjust.
 Identities = 43/168 (25%), Positives = 82/168 (48%), Gaps = 14/168 (8%)

Query: 110 TILYVDIVRSTEKAARLGDTRWATVMNHYYVAVRRELKALRGKEVVTTGDGVLATFRAPA 169
           T+++ D+V  +  + + GD     ++     AV   L    G  V   GDG++A FR P+
Sbjct: 139 TLVFTDLVGFSGWSLQAGDEATLALLRQVARAVESPLLDAGGHIVKRMGDGIMAVFRDPS 198

Query: 170 AGIRCATAIRESVRTLGL-----EIRVGLHAGEYQVSGAEVIGLAFHIGARVAAKARAGE 224
             ++   A  E+++++ +      IRVG+H G  Q   A+ +G+  +I ARV  +A  G 
Sbjct: 199 VAVQAVLAATEAMKSVEVGGYTPRIRVGIHTGRPQRLAADWLGVDVNIAARVMERATKGG 258

Query: 225 VLVSSAVKDLMSKSEIRF---------KDRGAHQLKGVPERWRLYRVE 263
           +++S    DL+ +S+++          K     +  G+P    +YR++
Sbjct: 259 IMISGPTLDLIPQSDLKELGIITRRVRKPMFTSKFTGIPPDMVIYRIK 306